|
Diabetes Mellitus, Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
CYP2R1 rs12794714 and rs10766196 polymorphisms were associated with a higher risk of type 1 diabetes.
|
31206955 |
2019 |
|
Coronary Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Two 25(OH)D reducing genetic variants in the DCHR7 gene (rs7944926 and rs11234027) and two in the CYP2R1 gene (rs10741657 and rs12794714) were genotyped in 92 416 participants of Danish descent, of whom 14 455 developed ischaemic heart disease (ICD-8:410-414; ICD-10:I20-I25) and 7061 myocardial infarction (ICD-8:410: ICD-10:I21-I22) from 1977 through 2011.
|
25981321 |
2015 |
|
Colorectal Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
In this study, no significant difference was observed for VDR (rs2238136), GC (rs4588), CYP2R1 (rs12794714), and CYP27B1 (rs3782130) gene variants in either genotype or allele frequencies between the cases with CRC and the controls and this lack of difference remained even after adjustment for age, BMI, sex, smoking status, NSAID use, and family history of CRC.
|
24568525 |
2014 |
|
Colorectal Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
A nominally significant association was detected between CRC and the SNP rs12794714 in the vitamin D 25-hydroxylase gene CYP2R1 (p = 0.019), a SNP that has previously been associated with serum vitamin D levels.
|
24562971 |
2014 |
|
Coronary Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Triangular relationship between single nucleotide polymorphisms in the CYP2R1 gene (rs10741657 and rs12794714), 25-hydroxyvitamin d levels, and coronary artery disease incidence.
|
25003556 |
2014 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
Whereas the rs12794714 polymorphism was not associated with type 1 diabetes the variant 'G' of the rs10741657 polymorphism was more often transmitted to affected offspring (61% vs 39% P = 0.004) and was also more frequent in cases than in controls (46.1% vs 35.7%, P = 0.03).
|
17607662 |
2007 |
|
Vitamin D Deficiency
|
|
0.010 |
GeneticVariation
|
BEFREE |
The GG+GA genotype of CYP2R1 rs12794714 and AA+AG genotype of CYP2R1 rs10766196 were associated with prevalent vitamin D deficiency in children with type 1 diabetes.
|
31206955 |
2019 |
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results showed that the CYP2R1 rs12794714-G, rs10741657-A, rs1562902-C, and rs10766197-G alleles were significantly associated with increased susceptibility to HCV infection (all P<sub>FDR</sub> < 0.05, in additive/dominant models), and the combined effect of the four unfavorable alleles was related to an elevated risk of HCV infection in a locus-dosage manner (P<sub>trend</sub> = 0.008).
|
31520221 |
2019 |
|
Asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that rs12794714 and rs10877012 SNPs were associated with asthma risk.
|
29502202 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
Gene-gene and gene-environment interaction analyses indicated that rs12794714-rs10766197 and rs12794714-vitamin D deficiency (VDD) models successfully predicted T2DM risk (P < 0.001).
|
30081191 |
2018 |
|
Myocardial Infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two 25(OH)D reducing genetic variants in the DCHR7 gene (rs7944926 and rs11234027) and two in the CYP2R1 gene (rs10741657 and rs12794714) were genotyped in 92 416 participants of Danish descent, of whom 14 455 developed ischaemic heart disease (ICD-8:410-414; ICD-10:I20-I25) and 7061 myocardial infarction (ICD-8:410: ICD-10:I21-I22) from 1977 through 2011.
|
25981321 |
2015 |
|
Myocardial Ischemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two 25(OH)D reducing genetic variants in the DCHR7 gene (rs7944926 and rs11234027) and two in the CYP2R1 gene (rs10741657 and rs12794714) were genotyped in 92 416 participants of Danish descent, of whom 14 455 developed ischaemic heart disease (ICD-8:410-414; ICD-10:I20-I25) and 7061 myocardial infarction (ICD-8:410: ICD-10:I21-I22) from 1977 through 2011.
|
25981321 |
2015 |
|
Coronary heart disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Triangular relationship between single nucleotide polymorphisms in the CYP2R1 gene (rs10741657 and rs12794714), 25-hydroxyvitamin d levels, and coronary artery disease incidence.
|
25003556 |
2014 |
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Triangular relationship between single nucleotide polymorphisms in the CYP2R1 gene (rs10741657 and rs12794714), 25-hydroxyvitamin d levels, and coronary artery disease incidence.
|
25003556 |
2014 |
|
Primary differentiated carcinoma of thyroid gland
|
|
0.010 |
GeneticVariation
|
BEFREE |
German patients (n=253) with DTC (papillary thyroid carcinoma [PTC] and follicular thyroid carcinoma [FTC]) and HC (n=302) were genotyped for polymorphisms within the vitamin D metabolizing enzymes such as 25-hydroxylase (CYP2R1[rs12794714, rs10741657]), 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1[rs10877012, rs4646536]), and 25-hydroxyvitamin D 24-hydrolase (CYP24A1[rs927650, rs2248137, rs2296241]).
|
22690899 |
2012 |
|
Differentiated Thyroid Gland Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
German patients (n=253) with DTC (papillary thyroid carcinoma [PTC] and follicular thyroid carcinoma [FTC]) and HC (n=302) were genotyped for polymorphisms within the vitamin D metabolizing enzymes such as 25-hydroxylase (CYP2R1[rs12794714, rs10741657]), 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1[rs10877012, rs4646536]), and 25-hydroxyvitamin D 24-hydrolase (CYP24A1[rs927650, rs2248137, rs2296241]).
|
22690899 |
2012 |
|
Follicular thyroid carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
German patients (n=253) with DTC (papillary thyroid carcinoma [PTC] and follicular thyroid carcinoma [FTC]) and HC (n=302) were genotyped for polymorphisms within the vitamin D metabolizing enzymes such as 25-hydroxylase (CYP2R1[rs12794714, rs10741657]), 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1[rs10877012, rs4646536]), and 25-hydroxyvitamin D 24-hydrolase (CYP24A1[rs927650, rs2248137, rs2296241]).
|
22690899 |
2012 |
|
Papillary thyroid carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
German patients (n=253) with DTC (papillary thyroid carcinoma [PTC] and follicular thyroid carcinoma [FTC]) and HC (n=302) were genotyped for polymorphisms within the vitamin D metabolizing enzymes such as 25-hydroxylase (CYP2R1[rs12794714, rs10741657]), 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1[rs10877012, rs4646536]), and 25-hydroxyvitamin D 24-hydrolase (CYP24A1[rs927650, rs2248137, rs2296241]).
|
22690899 |
2012 |