|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
CONCLUSIONS The genotypes CT, CT+TT, TT, and allele T in rs13347 may be risk factors for breast cancer.
|
29748526 |
2018 |
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
CONCLUSIONS The genotypes CT, CT+TT, TT, and allele T in rs13347 may be risk factors for breast cancer.
|
29748526 |
2018 |
|
Primary malignant neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
In conclusion, the results indicate that CD44 polymorphism rs13347 acts as a risk factor for cancer, especially in Chinese, while the minor allele of polymorphism rs11821102 may be associated with a decreased susceptibility to cancer.
|
28000766 |
2016 |
|
Primary malignant neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
Based on our analysis, we suggest significant role of CD44 variants (rs13347, rs187115 and rs11821102) in modulating individual's cancer susceptibility in Asians.
|
27521214 |
2016 |
|
Primary malignant neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
Subsequently, we conducted subgroup analysis for rs13347 polymorphism based on source of control, and we identified a significantly increased cancer risk for the population-based (P-B) group restricted to a recessive model (TT vs. TC+CC: OR = 2.030, 95%CI: 1.163-3.545, PAdjust < 0.001).
|
27738347 |
2016 |
|
Malignant Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
In conclusion, the results indicate that CD44 polymorphism rs13347 acts as a risk factor for cancer, especially in Chinese, while the minor allele of polymorphism rs11821102 may be associated with a decreased susceptibility to cancer.
|
28000766 |
2016 |
|
Malignant Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
Subsequently, we conducted subgroup analysis for rs13347 polymorphism based on source of control, and we identified a significantly increased cancer risk for the population-based (P-B) group restricted to a recessive model (TT vs. TC+CC: OR = 2.030, 95%CI: 1.163-3.545, PAdjust < 0.001).
|
27738347 |
2016 |
|
Malignant Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
Based on our analysis, we suggest significant role of CD44 variants (rs13347, rs187115 and rs11821102) in modulating individual's cancer susceptibility in Asians.
|
27521214 |
2016 |
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
However, both the polymorphisms- rs13347 and rs353639 had no effect on breast cancer susceptibility.
|
23940692 |
2013 |
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
However, both the polymorphisms- rs13347 and rs353639 had no effect on breast cancer susceptibility.
|
23940692 |
2013 |
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
CD44 rs13347 C>T polymorphism predicts breast cancer risk and prognosis in Chinese populations.
|
22788972 |
2012 |
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
These findings suggest that CD44 rs13347C>T polymorphism may affect breast cancer development and prognosis by increasing CD44 expression.
|
22788972 |
2012 |
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
These findings suggest that CD44 rs13347C>T polymorphism may affect breast cancer development and prognosis by increasing CD44 expression.
|
22788972 |
2012 |
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
CD44 rs13347 C>T polymorphism predicts breast cancer risk and prognosis in Chinese populations.
|
22788972 |
2012 |
|
Nasopharyngeal carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
All these findings suggest that CD44 rs13347C>T and rs115214213T>C polymorphisms may affect NPC development by improving CD44 expression.
|
25268088 |
2014 |
|
Nasopharyngeal carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
After statistical analysis we found that the minor alleles of rs13347 C/T and rs115214213 T/C are associated with NPC (OR = 1.94 95% CI = 1.44-2.62; OR = 2.07 95% CI = 1.65-2.60).
|
25268088 |
2014 |
|
Nasopharyngeal carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
All these findings suggest that CD44 rs13347C>T polymorphism may affect NPC development by improving CD44 expression.
|
23883608 |
2013 |
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
For the CD44 rs13347 site, mutations in the T allele might be a risk factor for HCC.
|
31301090 |
2019 |
|
Liver Cirrhosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results showed that patients with the CD44 rs13347 TT and T allele polymorphisms exhibited higher risks of LC than those carrying the CC genotype and C allele.
|
31301090 |
2019 |
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings suggest that the rs13347C/T in microRNA binding site may be potential biomarkers for genetic susceptibility to CRC.
|
26010608 |
2015 |
|
Hepatitis B
|
|
0.010 |
GeneticVariation
|
BEFREE |
Compared with the common genotype CC, individual who carried mutant genotypes (CT and TT) of rs13347 had a significantly high risk to suffer from HBV infection (OR=1.99, P=0.02 for CT; OR=3.56, P=3.00×10(-3) for TT), furthermore, CT+TT genotype also showed a high susceptibility (OR=2.27, P=2.00×10(-3)).
|
26617909 |
2015 |
|
Leukemia, Myelocytic, Acute
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, the potential role of rs13347C > T in AML was further explored.
|
24038513 |
2015 |
|
Leukemia, Myelocytic, Acute
|
|
0.010 |
GeneticVariation
|
BEFREE |
Above findings suggest that rs13347C>T in 3'UTR of CD44 may be a genetic modifier for developing AML.
|
24038513 |
2015 |
|
Non-Small Cell Lung Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
CD44 gene rs13347 polymorphism was not associated with NSCLC risk.
|
26356590 |
2015 |
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that the variant genotypes (CT and TT) of rs13347 (adjusted odds ratio (OR)=1.79, 95% confidence interval (CI)=1.50-2.17) increased an individual's susceptibility to CRC, compared with rs13347CC homozygous genotypes.
|
26010608 |
2015 |