|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
GWASDB |
Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4.
|
17447842 |
2007 |
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
GWASDB |
Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci.
|
17804789 |
2007 |
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci.
|
17804789 |
2007 |
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
GWASDB |
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
|
17068223 |
2006 |
|
Rheumatoid Arthritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Furthermore, the meta-analysis revealed a significant association between the rs1343151 polymorphism and RA susceptibility in Caucasians (C vs. T: OR = 0.91, 95% CI = 0.87-0.96, P = .0004).
|
31430553 |
2020 |
|
Rheumatoid Arthritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
In the IL23R gene rs1343151 SNP, the minor A allele significantly increased the risk of RA (Log OR = 0.085, 95% CI = 0.008, 0.156).
|
30924147 |
2019 |
|
Rheumatoid Arthritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
We found that the SNPs exert their susceptibility character in specific haplotype blocks: thus, for rheumatoid arthritis the rs1343151 SNP was risk factor only in a specific haplotype surrounding; this can explain the controversial results published so far about this variant.
|
23054009 |
2013 |
|
Rheumatoid Arthritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
This meta-analysis shows that the IL-23R rs1343151 and rs10489629 polymorphisms are associated with the development of RA in Europeans.
|
23053963 |
2012 |
|
Rheumatoid Arthritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
However there was some evidence for association of rs1343151 with RA (OR 1.14, 95% CI 1.06 to 1.22, p = <0.001).
|
18647855 |
2009 |
|
Ulcerative Colitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Similarly, meta-analyses of the rs7517847, rs1004819, rs10889677, rs2201841, rs11209032, rs1495965, rs1343151 and rs11465804 polymorphisms also indicated significant association with all UC (all P < 0.05).
|
27902482 |
2017 |
|
Ulcerative Colitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Moreover, meta-analysis revealed no association between the four alleles of the rs2201841, rs1004819, rs1495965 and rs1343151 polymorphisms and the risk of developing UC in Caucasian and Asian populations.
|
25497273 |
2015 |
|
Ankylosing spondylitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Conversely, minor alleles of rs10489629, rs11209026, rs11465804, and rs1343151 have protective effect on AS.
|
29944013 |
2018 |
|
Pediatric Crohn's disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
In comparison to disease-matched controls, patients with CD developing psoriasis following IFX therapy were more likely to be homozygous for specific polymorphisms in the IL-23R gene (rs10489628, rs10789229, and rs1343151).
|
23274341 |
2013 |
|
Psoriasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In comparison to disease-matched controls, patients with CD developing psoriasis following IFX therapy were more likely to be homozygous for specific polymorphisms in the IL-23R gene (rs10489628, rs10789229, and rs1343151).
|
23274341 |
2013 |
|
Behcet Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
SNPs rs10489629, rs1343151, and rs1495965 were also significantly associated with BD in all tests performed.
|
22378604 |
2012 |
|
Giant Cell Arteritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Role of rs1343151 IL23R and rs3790567 IL12RB2 polymorphisms in biopsy-proven giant cell arteritis.
|
21285166 |
2011 |
|
Uveomeningoencephalitic Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
The genotype and allele frequencies of rs17375018, rs7517847, rs11209032, and rs1343151 were not different between patients with VKH syndrome and healthy controls.
|
20116410 |
2010 |
|
Myocardial Infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
There was no association of any IL-23R (rs11209026, p = 0.82; rs7517847, p = 0.87; rs1343151, p = 0.85; rs10889677, p = 0.48) or IL-12B (rs3212227, p = 0.32) polymorphisms with MI.
|
17901940 |
2008 |