rs137852593, AR

N. diseases: 8
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.740 GeneticVariation BEFREE R726L substitution in the hormone binding region of androgen receptor was found in 1 prostate cancer family but no previously uncharacterized germline mutations were detected. 14665948 2004
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.740 GeneticVariation BEFREE R726L androgen receptor mutation is uncommon in prostate cancer families in the united states. 12539229 2003
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.740 GeneticVariation BEFREE To estimate the possible involvement of the prostate cancer predisposing AR Arg726Leu germ-line mutation in MBC, this mutation was tested in 117 MBC patients. 12602915 2003
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.740 GeneticVariation BEFREE The present study indicates that the R726L substitution in the AR may confer an up to 6-fold increased risk of prostate cancer and may contribute to cancer development in up to 2% of Finnish prostate cancer patients. 11103816 2000
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.740 GeneticVariation UNIPROT
PROSTATE CANCER, SUSCEPTIBILITY TO
CUI: C3469524
Disease: PROSTATE CANCER, SUSCEPTIBILITY TO
0.700 CausalMutation CLINVAR
Prostate carcinoma
CUI: C0600139
Disease: Prostate carcinoma
0.040 GeneticVariation BEFREE R726L substitution in the hormone binding region of androgen receptor was found in 1 prostate cancer family but no previously uncharacterized germline mutations were detected. 14665948 2004
Prostate carcinoma
CUI: C0600139
Disease: Prostate carcinoma
0.040 GeneticVariation BEFREE To estimate the possible involvement of the prostate cancer predisposing AR Arg726Leu germ-line mutation in MBC, this mutation was tested in 117 MBC patients. 12602915 2003
Prostate carcinoma
CUI: C0600139
Disease: Prostate carcinoma
0.040 GeneticVariation BEFREE R726L androgen receptor mutation is uncommon in prostate cancer families in the united states. 12539229 2003
Prostate carcinoma
CUI: C0600139
Disease: Prostate carcinoma
0.040 GeneticVariation BEFREE The present study indicates that the R726L substitution in the AR may confer an up to 6-fold increased risk of prostate cancer and may contribute to cancer development in up to 2% of Finnish prostate cancer patients. 11103816 2000
Malignant neoplasm of male breast
CUI: C0242787
Disease: Malignant neoplasm of male breast
0.010 GeneticVariation BEFREE To estimate the possible involvement of the prostate cancer predisposing AR Arg726Leu germ-line mutation in MBC, this mutation was tested in 117 MBC patients. 12602915 2003
Carcinoma of Male Breast
CUI: C0238033
Disease: Carcinoma of Male Breast
0.010 GeneticVariation BEFREE To estimate the possible involvement of the prostate cancer predisposing AR Arg726Leu germ-line mutation in MBC, this mutation was tested in 117 MBC patients. 12602915 2003
Prostate cancer, familial
CUI: C2931456
Disease: Prostate cancer, familial
0.010 GeneticVariation BEFREE The AR R726L allele does not account for a significant proportion of early-onset and/or familial prostate cancer in the United States. 12539229 2003
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.010 GeneticVariation BEFREE The present study indicates that the R726L substitution in the AR may confer an up to 6-fold increased risk of prostate cancer and may contribute to cancer development in up to 2% of Finnish prostate cancer patients. 11103816 2000
Malignant Neoplasms
CUI: C0006826
Disease: Malignant Neoplasms
0.010 GeneticVariation BEFREE The present study indicates that the R726L substitution in the AR may confer an up to 6-fold increased risk of prostate cancer and may contribute to cancer development in up to 2% of Finnish prostate cancer patients. 11103816 2000