|
Endometriosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Recently, two small Japanese studies reported eight SNPs (rs6542095, rs11677416, rs3783550, rs3783525, rs3783553, rs2856836, rs1304037 and rs17561) at the IL1A gene locus as suggestively associated with endometriosis risk.
|
25336714 |
2015 |
|
Endometriosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Although the exact mechanism through which this SNP alters risk of ovarian cancer is not clearly understood, rs17561 has also been associated with risk of endometriosis, an epidemiologic risk factor for ovarian cancer.
|
24272484 |
2014 |
|
Endometriosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Taken together, we examined association between rs17561 and endometriosis in an independent validation data set (524 patients and 533 healthy controls) replicating significant association (P=4.0 × 10(-5); odds ratio (OR), 1.91; 95% confidence interval (CI), 1.41-2.61).
|
23635948 |
2013 |
|
Multiple Sclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
No association was found between the IL-1α -889 (rs1800587), IL-1α +4,845 (rs17561), IL-1β -511 (rs16944), IL-1β +3,953 (rs1143634), IL-1ra variable number tandem repeat (VNTR) polymorphisms and MS risk.
|
23052182 |
2013 |
|
Multiple Sclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms in human pro- and anti-inflammatory genes, including IL1RN VNTR (rs315952), IL1A 4845G>T (rs17561), L1B-511C>T (rs16944), IL6-174G>C (rs1800795), IL10-1082 A>G (rs 1800896) and TNFα-308G>A (rs1800629) and their impact on multiple sclerosis risk and disease progression in a Polish population were investigated.
|
21621860 |
2011 |
|
Systemic Scleroderma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We did not see evidence regarding a positive role for rs1800587 or rs17561 in the risk of other autoimmune diseases, such as systemic sclerosis or rheumatoid arthritis.
|
29879187 |
2018 |
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We did not see evidence regarding a positive role for rs1800587 or rs17561 in the risk of other autoimmune diseases, such as systemic sclerosis or rheumatoid arthritis.
|
29879187 |
2018 |
|
Proliferative vitreoretinopathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
This analysis also showed statistically significant differences in genotype distributions between healthy controls and PVR patients in rs17561 of the <i>IL1A</i> gene (OR, 3.00; 95% CI, 0.77-11.75; <i>P</i> = 0.036) and in rs1800629 of the <i>TNF</i> gene (OR, 0.48; 95% CI, 0.27-0.87; <i>P</i> = 0.014).
|
29862067 |
2018 |
|
Autoimmune Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
We did not see evidence regarding a positive role for rs1800587 or rs17561 in the risk of other autoimmune diseases, such as systemic sclerosis or rheumatoid arthritis.
|
29879187 |
2018 |
|
Lhermitte-Duclos disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs2856836, rs1304037, rs17561 and rs1800587 variants of the IL1A gene were associated with the severity of LDD and Modic changes.
|
28081267 |
2017 |
|
Lumbar disc disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs2856836, rs1304037, rs17561 and rs1800587 variants of the IL1A gene were associated with the severity of LDD and Modic changes.
|
28081267 |
2017 |
|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Functional polymorphisms from IL1A (rs1800587, rs17561, rs11677416), IL1B (rs1143634, rs1143643, rs16944, rs4848306, rs1143623, rs1143633, rs1143627) and IL1RN (rs419598, rs315952, rs9005, rs4251961) genes were genotyped in 143 trio with schizophrenia.
|
28083609 |
2016 |
|
Periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results demonstrate that the IL-1α rs17561 and IL-1β rs1143634 polymorphisms are associated with periodontitis.
|
26909953 |
2016 |
|
Gilles de la Tourette syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest that IL-1α rs17561 and IL-1RN rs315952 polymorphisms may not be associated with susceptibility to TS in Chinese Han population.
|
26097611 |
2015 |
|
Malaria
|
|
0.010 |
GeneticVariation
|
BEFREE |
A GTGTGTC haplotype consisting of IL-1A (rs17561), IL-4 (rs2243250), TNF (rs1800750), IL-4R (rs1805015), NOS (rs8078340), CD40LG (rs1126535), and LUC7L (rs1211375) was significantly associated with the prevalence of malaria (POR: 1.822, 95% CI: 0.998-3.324).
|
26448013 |
2015 |
|
ovarian neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
Although the exact mechanism through which this SNP alters risk of ovarian cancer is not clearly understood, rs17561 has a</span>lso been associated with risk of endometriosis, an epidemiologic risk factor for ovarian cancer.
|
24272484 |
2014 |
|
Carcinoma, Ovarian Epithelial
|
|
0.010 |
GeneticVariation
|
BEFREE |
Although the exact mechanism through which this SNP alters risk of ovarian cancer is not clearly understood, rs17561 has a</span>lso been associated with risk of endometriosis, an epidemiologic risk factor for ovarian cancer.
|
24272484 |
2014 |
|
Malignant neoplasm of ovary
|
|
0.010 |
GeneticVariation
|
BEFREE |
Although the exact mechanism through which this SNP alters risk of ovarian cancer is not clearly understood, rs17561 has a</span>lso been associated with risk of endometriosis, an epidemiologic risk factor for ovarian cancer.
|
24272484 |
2014 |
|
Cervix carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
No significant association was observed between rs17561 and CC.
|
24862933 |
2014 |
|
Ankylosing spondylitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition to the three known IL-1 polymorphisms, rs2856836, rs17561, and rs1894399, found in previous meta-analysis, this meta-analysis shows that the IL-1F10.3 and IL-1A+889 polymorphisms are associated with the development of AS in Europeans but not in Asians.
|
21962386 |
2012 |
|
Migraine Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, the association of the occurrence and clinical characteristics of migraine with the polymorphisms of tumor necrosis factor alpha (TNF-alpha) -308 G/A (rs1800629), interleukin-1alpha (IL-1alpha) +4845 G/T (rs17561), IL-1beta+3953 C/T (rs1143634) and interleukin-1 receptor antagonist variable number tandem repeat (IL-1RA VNTR) genes were studied.
|
20113413 |
2010 |
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found a significantly increased breast cancer</span> risk with increasing minor alleles for IL1A A114S (rs17561); heterozygote OR 1.2 (95% CI, 1.0-1.4) and homozygote OR 1.5 (95% CI, 1.1-2.0), P(trend) = 0.008.
|
17932347 |
2007 |
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two IL1A SNPs (C-889T and Ala(114)Ser) were also related to lung cancer (OR, 1.18-1.22), although FPRPs were higher.
|
17596594 |
2007 |
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two IL1A SNPs (C-889T and Ala(114)Ser) were also related to lung cancer (OR, 1.18-1.22), although FPRPs were higher.
|
17596594 |
2007 |
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found a significantly increased breast cancer</span> risk with increasing minor alleles for IL1A A114S (rs17561); heterozygote OR 1.2 (95% CI, 1.0-1.4) and homozygote OR 1.5 (95% CI, 1.1-2.0), P(trend) = 0.008.
|
17932347 |
2007 |