rs17568, TNFRSF4

N. diseases: 12
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Acute Chest Syndrome
CUI: C0742343
Disease: Acute Chest Syndrome
0.020 GeneticVariation BEFREE When we stratified eligible studies by type of disease, positive results were observed for rs17568 variant in subjects with acute coronary syndrome (ACS) (allele model: P = 0.04, OR = 0.81, 95%CI, 0.65-0.99), for rs1234314 variant in subjects with coronary artery disease (CAD) (dominant model: P = 0.04, OR = 1.16, 95%CI, 1.00-1.35), for rs3850641 variant in subjects with CAD (recessive model: P = 0.02, OR = 1.42, 95%CI, 1.05-1.90) and myocardial infarction (MI) (recessive model: P = 0.03, OR = 1.49, 95%CI, 1.05-2.11). 30614039 2019
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.020 GeneticVariation BEFREE When we stratified eligible studies by type of disease, positive results were observed for rs17568 variant in subjects with acute coronary syndrome (ACS) (allele model: P = 0.04, OR = 0.81, 95%CI, 0.65-0.99), for rs1234314 variant in subjects with coronary artery disease (CAD) (dominant model: P = 0.04, OR = 1.16, 95%CI, 1.00-1.35), for rs3850641 variant in subjects with CAD (recessive model: P = 0.02, OR = 1.42, 95%CI, 1.05-1.90) and myocardial infarction (MI) (recessive model: P = 0.03, OR = 1.49, 95%CI, 1.05-2.11). 30614039 2019
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.020 GeneticVariation BEFREE Lack of association of tumor necrosis factor superfamily member 4 (TNFSF4) gene polymorphisms (rs3850641 and rs17568) with coronary heart disease and stroke: A systematic review and meta-analysis. 29424751 2018
Acute Chest Syndrome
CUI: C0742343
Disease: Acute Chest Syndrome
0.020 GeneticVariation BEFREE The results showed that carriers of the G allele of rs17568A/G had a significantly increased risk of ACS (p = 0.023, adjusted odds ratio = 1.72, 95% confidence interval = 1.08-2.75) after adjusting for age, sex, diabetes, hypertension, and lipids. 21476935 2011
Acute Coronary Syndrome
CUI: C0948089
Disease: Acute Coronary Syndrome
0.010 GeneticVariation BEFREE When we stratified eligible studies by type of disease, positive results were observed for rs17568 variant in subjects with acute coronary syndrome (ACS) (allele model: P = 0.04, OR = 0.81, 95%CI, 0.65-0.99), for rs1234314 variant in subjects with coronary artery disease (CAD) (dominant model: P = 0.04, OR = 1.16, 95%CI, 1.00-1.35), for rs3850641 variant in subjects with CAD (recessive model: P = 0.02, OR = 1.42, 95%CI, 1.05-1.90) and myocardial infarction (MI) (recessive model: P = 0.03, OR = 1.49, 95%CI, 1.05-2.11). 30614039 2019
Squamous cell carcinoma
CUI: C0007137
Disease: Squamous cell carcinoma
0.010 GeneticVariation BEFREE Our findings suggest the possible association of rs17568 GG genotype, as well as rs2298211 AA genotype with susceptibility to develop squamous cell carcinoma in the nose and sinonasal cavities. 30923998 2019
Squamous cell carcinoma of the head and neck
0.010 GeneticVariation BEFREE Association of OX40 gene polymorphisms (rs17568G/A and rs229811A/C) with head and neck squamous cell carcinoma. 30923998 2019
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.010 GeneticVariation BEFREE When we stratified eligible studies by type of disease, positive results were observed for rs17568 variant in subjects with acute coronary syndrome (ACS) (allele model: P = 0.04, OR = 0.81, 95%CI, 0.65-0.99), for rs1234314 variant in subjects with coronary artery disease (CAD) (dominant model: P = 0.04, OR = 1.16, 95%CI, 1.00-1.35), for rs3850641 variant in subjects with CAD (recessive model: P = 0.02, OR = 1.42, 95%CI, 1.05-1.90) and myocardial infarction (MI) (recessive model: P = 0.03, OR = 1.49, 95%CI, 1.05-2.11). 30614039 2019
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.010 GeneticVariation BEFREE Similarly, no susceptibility between CHD and stroke and rs17568 polymorphism was uncovered (GG vs. AA: OR=1.04, 95% CI=0.74-1.46; GA vs. AA: OR=1.07, 95% CI=0.62-1.83; GG+GA vs. AA: OR=1.13, 95% CI=0.82-1.56; GG vs. GA+AA: OR=1.01, 95% CI=0.74-1.39). 29424751 2018
Coronary Arteriosclerosis
CUI: C0010054
Disease: Coronary Arteriosclerosis
0.010 GeneticVariation BEFREE Lack of association of tumor necrosis factor superfamily member 4 (TNFSF4) gene polymorphisms (rs3850641 and rs17568) with coronary heart disease and stroke: A systematic review and meta-analysis. 29424751 2018
Cerebrovascular accident
CUI: C0038454
Disease: Cerebrovascular accident
0.010 GeneticVariation BEFREE Similarly, no susceptibility between CHD and stroke and rs17</span>568 polymorphism was uncovered (GG vs. AA: OR=1.04, 95% CI=0.74-1.46; GA vs. AA: OR=1.07, 95% CI=0.62-1.83; GG+GA vs. AA: OR=1.13, 95% CI=0.82-1.56; GG vs. GA+AA: OR=1.01, 95% CI=0.74-1.39). 29424751 2018
Hyperlipoproteinemia Type I
CUI: C0023817
Disease: Hyperlipoproteinemia Type I
0.010 GeneticVariation BEFREE These results suggest that the rs3850641 and rs17568 polymorphisms in the OX40L and OX40 genes are associated with some of the lipid and lipoprotein variations in subjects with endogenous HTG and/or in the general population of Han Chinese. 23216302 2013
Diabetes
CUI: C0011847
Disease: Diabetes
0.010 GeneticVariation BEFREE The results showed that carriers of the G allele of rs17568A/G had a significantly increased risk of ACS (p = 0.023, adjusted odds ratio = 1.72, 95% confidence interval = 1.08-2.75) after adjusting for age, sex, diabetes, hypertension, and lipids. 21476935 2011
Diabetes Mellitus
CUI: C0011849
Disease: Diabetes Mellitus
0.010 GeneticVariation BEFREE The results showed that carriers of the G allele of rs17568A/G had a significantly increased risk of ACS (p = 0.023, adjusted odds ratio = 1.72, 95% confidence interval = 1.08-2.75) after adjusting for age, sex, diabetes, hypertension, and lipids. 21476935 2011