|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
The results suggested that rs17782313 polymorphism was significantly associated with obesity risk (OR=1.18, 95%CI=1.15-1.21, p<0.001).
|
23049848 |
2012 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
We investigated the association between genetic variants in FTO (rs9939609) and near MC4R (rs17782313) with obesity- and type 2 diabetes (T2DM)-related traits in a longitudinal birth cohort of 2,151 healthy individuals from the Vellore birth cohort in South India.
|
22421923 |
2012 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our data support that the rs9939609 and rs17782313 are strongly associated with obesity and BMI.
|
21063808 |
2011 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
In sum, our data support the associations of variants rs17782313 and rs12970134 near MC4R with early onset obesity and increased insulin levels.
|
21372613 |
2011 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
In conclusion, we could replicate the previously reported association between rs17782313 and complex obesity.
|
21303735 |
2011 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Several independent genome-wide association studies recently identified two common polymorphisms, FTO rs9939609 and MC4R rs17782313, that are linked to increased body weight and obesity.
|
21347432 |
2011 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
We have previously demonstrated that three obesity-susceptible single nucleotide polymorphisms (SNPs), rs10938397 (GNPDA2), rs8050136 (FTO) and rs17782313 (MC4R), were associated with obesity and waist circumference in cross-sectional studies in the Chinese population.
|
21147891 |
2011 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Most notably, the association between 5 SNPs (Fas apoptotic inhibitory molecule 2 rs7138803, Niemann-Pick disease, type C1 rs1805081, fat mass- and obesity-associated gene rs6499640, melanocortin 4 receptor gene rs17782313, and brain-derived neurotrophic factor rs6265) and obesity risk was only observed in children who had moderate-to-low physical activity levels or engaged in sedentary behavior, regardless of which risk alleles they carried.
|
21527513 |
2011 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
After age and sex adjustment and correction for multiple testing, the SNPs rs17782313, rs6265, and rs10938397 were associated with BMI (P = 1.0 × 10⁻⁵, 0.038, and 0.00093, respectively) and also obesity (P = 5.0 × 10⁻⁶, 0.043, and 0.00085, respectively) in the Chinese children.
|
20843981 |
2010 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
The common polymorphism rs17782313 lying 188 kb downstream of the MC4R gene has recently been found to be unequivocally associated with body mass index (BMI) and obesity risk in adults and children.
|
20215774 |
2010 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Both rs17782313 (near MC4R) and rs1421085 (FTO) polymorphisms have been consistently associated with increased risk of obesity and with body mass index (BMI) variation.
|
19153581 |
2009 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
In case-control studies of obesity defined by BMI, the minor C-allele of rs17782313 was associated with overweight/obesity and obesity (odds ratio [OR] 1.09, P = 0.006 and OR 1.12, P = 0.003, respectively).
|
19073769 |
2009 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently a modest, but consistently, replicated association was demonstrated between obesity and the single-nucleotide polymorphism (SNP), rs17782313, 3' of the MC4R locus as a consequence of a meta-analysis of genome-wide association (GWA) studies of the disease in white populations.
|
19265794 |
2009 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.
|
19151714 |
2009 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.
|
19151714 |
2009 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Here, we investigated the involvement of FTO rs9939609 and MC4R rs17782313 polymorphisms in the development of obesity.
|
19668254 |
2009 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
The MC4R rs17782313 C allele was more associated with obesity and fat mass deposition in males than in females (P = 0.003 and P = 0.03, respectively) and low physical activity accentuated the effect of the FTO polymorphism on BMI increase and obesity prevalence (P = 0.008 and P = 0.01, respectively).
|
19255736 |
2009 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
We focused on physical activity as an environmental risk factor, and on the GWA identified obesity variants in FTO (rs9939609) and near MC4R (rs17782313) as genetic risk factors.
|
18682847 |
2008 |