|
Obesity
|
|
0.890 |
GeneticVariation
|
BEFREE |
Risk allele carriers of rs17817449 SNP had somewhat higher values of weight, body mass index, waist and hip circumference, total cholesterol, triglycerides, adiponectin, and fasting glucose.This study revealed the genetic association between rs9939609 SNP of FTO and obesity in a Romanian population, and to the authors' knowledge, this is the first study to investigate this association in a Romanian population.
|
27196486 |
2016 |
|
Obesity
|
|
0.890 |
GeneticVariation
|
BEFREE |
In single locus analysis, FTO rs8050136 CA (p = 0.0001; OR (95% CI) = 2.4 (1.7-3.4) and AA (p = 0.0001; OR (95% CI) = 3.1 (1.9-5.2); FTO rs1421085 TA (p = 0.0001; OR (95% CI) = 2.1 (1.4-3.0) and AA (p = 0.0001; OR (95% CI) = 3.0 (1.8-5.0); FTO rs9939609 TC (p = 0.0001; OR (95% CI) = 2.1 (1.5-3.1) and CC (p = 0.0001; OR (95% CI) = 4.2 (2.5-7.3) along with TG (p = 0.001; OR (95% CI) = 2.1 (1.3-3.2) and GG (p = 0.021; OR (95% CI) = 3.8 (1.2-11.8) genotypes of FTO rs17817449 with GT (p = 0.0001; OR (95% CI) = 2.1 (1.5-3.1) and TT (p = 0.012; OR (95% CI) = 3.3 (1.8-3.6) genotypes of IRX3 rs3751723 were significantly associated with obesity.
|
26440677 |
2016 |
|
Obesity
|
|
0.890 |
GeneticVariation
|
BEFREE |
The SNPs rs1421085, rs17817449 and rs8043757 in the first intron of the FTO gene are associated with increasing risk of obesity in Thais.
|
25542809 |
2015 |
|
Obesity
|
|
0.890 |
GeneticVariation
|
BEFREE |
Numerous studies have demonstrated that the common variants (rs1421085 and rs17817449) of the fat mass and obesity associated (FTO) gene are associated with the obesity in adult and children in European.
|
24331679 |
2014 |
|
Obesity
|
|
0.890 |
GeneticVariation
|
GWASDB |
For the binary trait of obesity, we found 16 genome-wide significant signals within the FTO gene (strongest signal at rs17817449, P = 2.5 × 10(-12)).
|
21552555 |
2011 |
|
Obesity
|
|
0.890 |
GeneticVariation
|
BEFREE |
This study replicated the genetic association of SNP of FTO (rs17817449) with obesity in a north Indian population and, to the authors' knowledge; this is the first such association study in a north Indian population.
|
21919686 |
2011 |
|
Obesity
|
|
0.890 |
GeneticVariation
|
GWASCAT |
For the binary trait of obesity, we found 16 genome-wide significant signals within the FTO gene (strongest signal at rs17817449, P = 2.5 × 10(-12)).
|
21552555 |
2011 |
|
Obesity
|
|
0.890 |
GeneticVariation
|
BEFREE |
Significant associations were detected between obesity risk and the five polymorphisms: rs9939609 (OR: 1.31, 95% CI: 1.26 to 1.36), rs1421085 (OR: 1.43, 95% CI: 1.33 to 1.53), rs8050136 (OR: 1.25, 95% CI: 1.13 to 1.38), rs17817449 (OR: 1.54, 95% CI: 1.41 to 1.68), and rs1121980 (OR: 1.34, 95% CI: 1.10 to 1.62).
|
21651756 |
2011 |
|
Obesity
|
|
0.890 |
GeneticVariation
|
GWASDB |
Genome-wide population-based association study of extremely overweight young adults--the GOYA study.
|
21935397 |
2011 |
|
Obesity
|
|
0.890 |
GeneticVariation
|
BEFREE |
For the binary trait of obesity, we found 16 genome-wide significant signals within the FTO gene (strongest signal at rs17817449, P = 2.5 × 10(-12)).
|
21552555 |
2011 |
|
Obesity
|
|
0.890 |
GeneticVariation
|
BEFREE |
To widen the geographical coverage of the FTO studies, we have analyzed the association between the FTO gene variant rs17817449 (G>C) and obesity in a Slavic Eastern European population.
|
18833210 |
2008 |
|
Obesity
|
|
0.890 |
GeneticVariation
|
BEFREE |
In European populations, common variants (rs1421085-C, rs17817449-G, and rs9939609-A) in the fat mass and obesity (FTO associated) were recently found to be associated with body mass index (BMI) or obesity.
|
17928949 |
2007 |
|
Breast Carcinoma
|
|
0.720 |
GeneticVariation
|
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
|
Breast Carcinoma
|
|
0.720 |
GeneticVariation
|
GWASCAT |
Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer.
|
27117709 |
2016 |
|
Malignant neoplasm of breast
|
|
0.720 |
GeneticVariation
|
BEFREE |
Of 41 recently discovered breast cancer susceptibility variants, associations were found between rs1432679 (EBF1), rs17817449 (MIR1972-2: FTO), rs12710696 (2p24.1), and rs3757318 (ESR1) and adjusted absolute and percent dense areas, respectively.
|
25862352 |
2015 |
|
Breast Carcinoma
|
|
0.720 |
GeneticVariation
|
BEFREE |
Of 41 recently discovered breast cancer susceptibility variants, associations were found between rs1432679 (EBF1), rs17817449 (MIR1972-2: FTO), rs12710696 (2p24.1), and rs3757318 (ESR1) and adjusted absolute and percent dense areas, respectively.
|
25862352 |
2015 |
|
Breast Carcinoma
|
|
0.720 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
|
25751625 |
2015 |
|
Malignant neoplasm of breast
|
|
0.720 |
GeneticVariation
|
GWASDB |
Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
|
23535733 |
2013 |
|
Breast Carcinoma
|
|
0.720 |
GeneticVariation
|
BEFREE |
Seven SNPs were statistically significant (P ≤ 0.05) with the risk of overall breast cancer in the same direction as previously reported: rs10069690 (5p15/TERT), rs999737 (14q24/RAD51L1), rs13387042 (2q35/TNP1), rs1219648 (10q26/FGFR2), rs8170 (19p13/BABAM1), rs17817449 (16q12/FTO), and rs13329835 (16q23/DYL2).
|
23593120 |
2013 |
|
Malignant neoplasm of breast
|
|
0.720 |
GeneticVariation
|
GWASDB |
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
|
23535729 |
2013 |
|
Breast Carcinoma
|
|
0.720 |
GeneticVariation
|
GWASCAT |
Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
|
23535733 |
2013 |
|
Breast Carcinoma
|
|
0.720 |
GeneticVariation
|
GWASCAT |
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
|
23535729 |
2013 |
|
Malignant neoplasm of breast
|
|
0.720 |
GeneticVariation
|
BEFREE |
Seven SNPs were statistically significant (P ≤ 0.05) with the risk of overall breast cancer in the same direction as previously reported: rs10069690 (5p15/TERT), rs999737 (14q24/RAD51L1), rs13387042 (2q35/TNP1), rs1219648 (10q26/FGFR2), rs8170 (19p13/BABAM1), rs17817449 (16q12/FTO), and rs13329835 (16q23/DYL2).
|
23593120 |
2013 |
|
Body mass index
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genetic analyses of diverse populations improves discovery for complex traits.
|
31217584 |
2019 |
|
Finding of body mass index
|
|
0.700 |
GeneticVariation
|
GWASDB |
EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children.
|
24348519 |
2013 |