|
Obesity
|
|
0.810 |
GeneticVariation
|
BEFREE |
Recent genome-wide association studies identified a single nucleotide variant (SNV) in the GIPR encoding gene (GIPR), rs1800437, that is associated with obesity and insulin resistance.
|
30784161 |
2019 |
|
Obesity
|
|
0.810 |
GeneticVariation
|
GWASDB |
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
23563607 |
2013 |
|
Obesity
|
|
0.810 |
GeneticVariation
|
GWASCAT |
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
23563607 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.
|
29632382 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.710 |
GeneticVariation
|
BEFREE |
The haplotype A (rs2302382) C (rs1800437) was associated with an increased risk of T2DM.
|
28744963 |
2017 |
|
Waist-Hip Ratio
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
|
30239722 |
2019 |
|
Waist Circumference
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank.
|
31453325 |
2019 |
|
Body mass index
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
|
30239722 |
2019 |
|
body fat percentage (physical finding)
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genomics of body fat percentage may contribute to sex bias in anorexia nervosa.
|
30593698 |
2019 |
|
Body mass index
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
|
29273807 |
2018 |
|
Body mass index
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.
|
28448500 |
2017 |
|
Glucose tolerance test
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genetic determinants of circulating GIP and GLP-1 concentrations.
|
29093273 |
2017 |
|
Physical Activity Measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.
|
28448500 |
2017 |
|
Insulin measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genetic determinants of circulating GIP and GLP-1 concentrations.
|
29093273 |
2017 |
|
Heart failure
|
|
0.010 |
GeneticVariation
|
BEFREE |
From these, rs10189761 and rs737337 variants were independently associated with HF prognosis (HR 2.295 (1.287-4.089, 95% CI); p = 0.005), whereas rs10423928, rs1800437, rs737337 and rs9351814 were related with bad prognosis only in obese patients (HR 2.142 (1.438-3.192, 95% CI); p = 0.00018).
|
31209632 |
2019 |
|
Congestive heart failure
|
|
0.010 |
GeneticVariation
|
BEFREE |
From these, rs10189761 and rs737337 variants were independently associated with HF prognosis (HR 2.295 (1.287-4.089, 95% CI); p = 0.005), whereas rs10423928, rs1800437, rs737337 and rs9351814 were related with bad prognosis only in obese patients (HR 2.142 (1.438-3.192, 95% CI); p = 0.00018).
|
31209632 |
2019 |
|
Pediatric Obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, we screened the GIPR gene for mutations and examined the association between three single-nucleotide polymorphisms (SNPs; rs8111428, rs2302382, rs1800437) and childhood obesity, as well as impaired glucose homeostasis.
|
20516203 |
2010 |
|
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
For GIPR Glu354Gln, we obtained a nominal association of heterozygous minor allele carrier with CVD in a codominant model adjusted for BMI, sex, and age (OR: 0.67, CI: 0.50-0.91, p = 0.01) or additional covariates of CVD (OR: 0.72, CI: 0.52-0.97, p = 0.03).
|
17624916 |
2007 |