|
Major Depressive Disorder
|
|
0.040 |
GeneticVariation
|
BEFREE |
We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression.
|
31721892 |
2019 |
|
Major Depressive Disorder
|
|
0.040 |
GeneticVariation
|
BEFREE |
The A allele at TPH1 rs1800532 may be associated with citalopram efficacy only in melancholic and psychotic MDD.
|
23221997 |
2013 |
|
Major Depressive Disorder
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our aim was to assess the association of TPH1 A218C polymorphism (rs1800532) with mood disorders, including major depressive disorder and bipolar disorder, and alcohol dependence by using meta-analysis.
|
21601290 |
2012 |
|
Major Depressive Disorder
|
|
0.040 |
GeneticVariation
|
BEFREE |
One hundred five healthy controls and 115 outpatients diagnosed with MDD were recruited and genotyped for the TPH1 218A/C (rs1800532) polymorphism.
|
20945066 |
2011 |
|
Unipolar Depression
|
|
0.020 |
GeneticVariation
|
BEFREE |
We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression.
|
31721892 |
2019 |
|
Mood Disorders
|
|
0.020 |
GeneticVariation
|
BEFREE |
Three hundred and ninety-eight patients diagnosed with mood disorders were genotyped for TPH1 G-6526A promoter polymorphism (rs4537731) and the A218C intron 7 polymorphism (rs1800532) and a set of ancestry informative markers, assessed for Diagnostic and Statistical Manual of Mental Disorders, 4th edition diagnoses, and assessed for a history of physical and sexual abuse.
|
21989108 |
2012 |
|
Unipolar Depression
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our aim was to assess the association of TPH1 A218C polymorphism (rs1800532) with mood disorders, including major depressive disorder and bipolar disorder, and alcohol dependence by using meta-analysis.
|
21601290 |
2012 |
|
Mood Disorders
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our aim was to assess the association of TPH1 A218C polymorphism (rs1800532) with mood disorders, including major depressive disorder and bipolar disorder, and alcohol dependence by using meta-analysis.
|
21601290 |
2012 |
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
Therefore, this study aimed to investigate the association between the occurrence of <i>TPH1, TPH2, KAT1, KAT2</i> and <i>IDO1</i> polymorphisms and the risk of stroke development.The following 10 polymorphisms of the genes encoding enzymes of the TRYCATs pathway were selected: c.804-7C > A (rs10488682), c.-1668T > A (rs623580), c.803+221C > A (rs1800532), c.-173A > T (rs1799913) - <i>TPH1</i>, c.-1449C > A (rs7963803), and c.-844G > T (rs4570625) - <i>TPH2</i>. c.*456G > A of <i>KAT1</i> (rs10988134), c.975-7T > C of <i>KAT2</i> (rs1480544), c.-1849C > A (rs3824259) and c. -1493G > C (rs10089084) of <i>IDO1</i>.
|
31817010 |
2019 |
|
Depressive disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated gray matter volume (GMV) differences, TPH1 rs1800532 and rs1799913 polymorphisms previously found to be associated with depressive disorder and SB, and the relationship between the two markers.
|
30602107 |
2018 |
|
Drug habituation
|
|
0.010 |
GeneticVariation
|
BEFREE |
While effects of 5-HTTLPR and of a serotonergic multi-marker score (5-HTTLPR, TPH1(rs1800532), TPH2(rs4570625), HTR1A(rs6295) and HTR2A(rs6311)) on amygdala activation did not withstand correction for multiple regions of interest, we observed a strong correlation of the multi-marker score and habituation in the amygdala, DLPFC, and ACC.
|
29358097 |
2018 |
|
Suicidal
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic association studies have revealed contradictory results about the effect of the TPH1 A218C (rs1800532) polymorphism on suicidal behavior in different populations.
|
27497328 |
2016 |
|
Panic Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Nominal associations that did not survive correction for multiple testing were observed for NPSR1 rs324891 (T allele: OR=1.22, 95% CI: 1.07-1.38, P=0.002), TPH1 rs1800532 (AA genotype: OR=1.46, 95% CI: 1.14-1.89, P=0.003) and HTR2A rs6313 (T allele: OR=1.19, 95% CI: 1.07-1.33, P=0.002) in studies with samples of European ancestry and for MAOA-uVNTR in female PD (low-active alleles: OR=1.21, 95% CI: 1.07-1.38, P=0.004).
|
26390831 |
2016 |
|
Opiate Addiction
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated whether 2 serotonergic polymorphisms, TPH1 A218C (rs1800532) and 5-HTT-linked promoter region (5-HTTLPR) (rs25531), are differently associated with alcohol or opiate dependence.
|
27045756 |
2016 |
|
Irritable Bowel Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, TPH1 gene SNPs were associated with IBS-related cognitions (rs4537731 and rs21105) and quality of life (rs684302 and rs1800532), in particular the mental health and energy subscales.
|
23172723 |
2014 |
|
Depressed mood
|
|
0.010 |
GeneticVariation
|
BEFREE |
The A allele at TPH1 rs1800532 may be associated with citalopram efficacy only in melancholic and psychotic MDD.
|
23221997 |
2013 |
|
Mental disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three hundred and ninety-eight patients diagnosed with mood disorders were genotyped for TPH1 G-6526A promoter polymorphism (rs4537731) and the A218C intron 7 polymorphism (rs1800532) and a set of ancestry informative markers, assessed for Diagnostic and Statistical Manual of Mental Disorders, 4th edition diagnoses, and assessed for a history of physical and sexual abuse.
|
21989108 |
2012 |
|
Alcoholic Intoxication, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our aim was to assess the association of TPH1 A218C polymorphism (rs1800532) with mood disorders, including major depressive disorder and bipolar disorder, and alcohol dependence by using meta-analysis.
|
21601290 |
2012 |
|
Drug abuse
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three hundred and ninety-eight patients diagnosed with mood disorders were genotyped for TPH1 G-6526A promoter polymorphism (rs4537731) and the A218C intron 7 polymorphism (rs1800532) and a set of ancestry informative markers, assessed for Diagnostic and Statistical Manual of Mental Disorders, 4th edition diagnoses, and assessed for a history of physical and sexual abuse.
|
21989108 |
2012 |
|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
We, therefore, explored the association of TPH2 gene with schizophrenia using a case-control study of 720 Japanese populations and also tried to replicate the association of the TPH1 rs1800532 (A218C) single nucleotide polymorphism (SNP) with schizophrenia.
|
20144688 |
2010 |