|
Rheumatoid Arthritis
|
|
0.720 |
GeneticVariation
|
BEFREE |
The lack of positive association of TNF-α -863(rs1800630) polymorphism in our study group implies that TNF-α -863 polymorphism is not a susceptible marker to RA and cannot serve as a genetic factor for screening RA patients in Pakistan.
|
30899307 |
2019 |
|
Rheumatoid Arthritis
|
|
0.720 |
GeneticVariation
|
BEFREE |
Recent advances have highlighted a major genetic contribution to the pathogenesis of rheumatoid arthritis (RA).The aim of this study was to investigate whether polymorphisms of TNF-α (rs1800630, rs1800629) and TNFR1 (rs767455) were associated with susceptibility to and clinical outcome of RA in Chinese Han population.
|
25263964 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
Therefore, this work was planned to evaluate the association of -863C/A (rs1800630) and -1031T/C (rs1799964) polymorphisms in TNF gene with plasma TNF-α levels and DN among subjects with type 2 diabetes (T2DM) in a population from North India.
|
25704106 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
This is the first report demonstrating association of rs1800630 and rs2229094 with type 2 diabetes in any population, suggesting an important role of the TNF-LTA locus in type 2 diabetes in North Indians.
|
20177654 |
2010 |
|
Tuberculosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, TNF rs1799964 and rs1800630 were risk factors for susceptibility to TB, which were validated in the Chinese Tibetan population.
|
30792445 |
2019 |
|
Age related macular degeneration
|
|
0.010 |
GeneticVariation
|
BEFREE |
To study polymorphisms in promotor regions of <i>tumor necrosis factor (TNF)-α TNF-863A/C</i> (rs1800630), <i>TNF-308A/G</i> (rs1800629), and <i>TNF-238A/G</i> (rs361525) in patients with age-related macular degeneration (AMD) and associations of complex <i>TNF-α</i> genotypes with AMD.
|
30662836 |
2019 |
|
Glaucoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Thus present study aimed to analyze the association of TNF-α promoter region alterations (c.-238G>A (rs361525), c.-308G>A (rs1800629), c.-857C>T (rs1799724) and c.-863C>A (rs1800630)) with glaucoma in north Indian cohort.
|
31132515 |
2019 |
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The study results revealed that IL-1β rs1143627: T > C, rs16944: C > T (p = 0.001;OR = 1.85; 95% CI 1.30-2.63) and rs1143633: G > A (p < 0.0001; OR = 2.53; 95% CI 1.67-3.83) and TNF-α rs1800630: C > A, rs1799964: T > C (p < 0.0001; OR = 2.31; 95% CI 1.54-3.46) polymorphisms significantly contributed toward GC risk.
|
30094865 |
2018 |
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
The study results revealed that IL-1β rs1143627: T > C, rs16944: C > T (p = 0.001;OR = 1.85; 95% CI 1.30-2.63) and rs1143633: G > A (p < 0.0001; OR = 2.53; 95% CI 1.67-3.83) and TNF-α rs1800630: C > A, rs1799964: T > C (p < 0.0001; OR = 2.31; 95% CI 1.54-3.46) polymorphisms significantly contributed toward GC risk.
|
30094865 |
2018 |
|
Ankylosing spondylitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
For rs1800630, the A allele was also linked to reduced risk of AS (p < 0.0001, OR = 0.59, 95% CI = 0.48-0.72).
|
29230494 |
2018 |
|
Hepatitis B, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
To test this hypothesis, we investigated the role of TNF-α polymorphism [-863C/A (rs1800630), -308G/A (rs1800629), -376G/A (rs1800750), -857C/T (rs1799724) and +489G/A (rs1800610)] in the susceptibility to chronic hepatitis B (CHB) infection.
|
29054398 |
2017 |
|
Chronic Periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphisms of: 1) FCGR2A 131His/Arg (rs1801274); 2) FCGR2B 232Ile/Thr (rs1050501); 3) TNFA -1031T/C (rs1799964); and 4) TNFA -863C/A (rs1800630) were analyzed among patients with healthy gingiva (n = 176) and patients with CP (n = 177).
|
27063995 |
2016 |
|
Leprosy
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, we evaluated the single nucleotide polymorphisms (SNPs) -238 G/A (rs361525), -308 G/A (rs1800629), -857 C/T (rs1799724), -863 A/C (rs1800630) and -1031 T/C (rs1799964) in the promoter region of the TNF to see whether these SNPs influence host-susceptibility to leprosy and the different clinical manifestation.
|
25636570 |
2015 |
|
Diabetic Nephropathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Therefore, this work was planned to evaluate the association of -863C/A (rs1800630) and -1031T/C (rs1799964) polymorphisms in TNF gene with plasma TNF-α levels and DN among subjects with type 2 diabetes (T2DM) in a population from North India.
|
25704106 |
2015 |
|
Acute periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
A meta-analysis was performed to assess the effect of TNF-α -308G/A (rs1800629), -238G/A (rs361525) and -863C/A (rs1800630) polymorphisms on either chronic (CP) or aggressive periodontitis (AgP) risk.
|
24905365 |
2014 |
|
Aggressive Periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
A meta-analysis was performed to assess the effect of TNF-α -308G/A (rs1800629), -238G/A (rs361525) and -863C/A (rs1800630) polymorphisms on either chronic (CP) or aggressive periodontitis (AgP) risk.
|
24905365 |
2014 |
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study we genotyped four common single nucleotide polymorphisms (SNPs) in the TNF-α promoter [ -308G > A(rs1800629), -857C > T (rs1799724), -863C > A (rs1800630), and -1031T > C (rs1799964)] and determined HPV16 serology in 325 OSCC cases and 335 matched controls and tumor HPV status in 176 squamous cell carcinomas of the oropharynx (SCCOP) patients.
|
23870134 |
2013 |
|
Recurrent mouth ulcers
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study suggests that the TNF-α (rs1800629 and rs1800630) genotype is an indicator for the susceptibility of recurrent oral ulceration.
|
23406059 |
2013 |
|
Complicated malaria
|
|
0.010 |
GeneticVariation
|
BEFREE |
We examined a possible association of three single nucleotide polymorphisms (SNPs) of the tumor necrosis factor alpha (TNF) promoter -1031T>C (rs1799964), -863C>A (rs1800630), and -857C>T (rs1799724) with severe malaria in 466 adult patients having Plasmodium falciparum malaria in northwest Thailand.
|
17493155 |
2007 |