|
Abnormal behavior
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the present study, we genotyped two interleukin 6 (IL-6) variants (rs2069845 and rs1800795) in 320 suicide attempters, 236 suicide completers, and 341 individuals without any history of psychiatric disorders or suicide ideation.
|
30269203 |
2018 |
|
Acute Chest Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the present study we investigated whether variants at -1082G→A (rs1800896) and -592C→A (rs1800872) of interleukin-10 (IL-10), -1188A→C (rs3212227) of IL-12 p40, -308G→A of tumor necrosis factor-α (TNF-α) (rs1800629), -174G→C of IL-6 (rs1800795) and +874A→T of interferon-γ (IFN-γ) genes (rs2430561) are associated with ACS.
|
22372709 |
2012 |
|
Acute GVH disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Similar to previous publications, the IL6 donor genotype for rs1800795 was associated with a 20%-50% increased risk for grade IIb-IV aGVHD after unrelated HCT in the allelic (adjusted P = .011) and recessive (adjusted P = .0013) models.
|
22282500 |
2012 |
|
Acute GVH disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Furthermore, the IL-6R rs4845618 donor genotype showed an association with severe acute graft-versus-host disease (GVHD), whereas the donor genotype of the IL-6 SNP rs1800795 was associated with decreased survival 100 days post-transplant.
|
29513361 |
2018 |
|
Acute pancreatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, there were no significant associations between IL-1β (IL-1β +3954 C/T (rs1143634) and IL-1β -511 C/T (rs16944)), IL-6 (IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796)) and IL-10 (IL-10 -1082 A/G (rs1800896), IL-10 -819 C/T (rs1800871) and IL-10 -592 C/A (rs1800872)) gene polymorphisms and AP risk.
|
24072654 |
2013 |
|
Adenoma of large intestine
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the inter-relationships of serum levels of the inflammatory proteins CRP and in IL-6, single nucleotide polymorphisms (SNPs) in the CRP (rs1205, rs1130864, rs1800947) and IL6 (rs1800795) genes, and lifestyle factors with colorectal adenoma in a sigmoidoscopy-based case-control study of 271 adenoma cases and 539 age-, sex-, and race/ethnicity-matched controls in Hawaii.
|
20333461 |
2010 |
|
Adolescent idiopathic scoliosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study is to replicate the association between the promoter polymorphisms of matrix metalloproteinase (MMP)-3 (-1171 5A/6A rs3025058) and interleukin (IL)-6 genes (-174G/C rs1800795) and adolescent idiopathic scoliosis (AIS) in a Chinese Han population.
|
20436380 |
2010 |
|
Adult Diffuse Large B-Cell Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Given the importance of understanding the genetic variations involved in the pathogenesis of non-Hodgkin's lymphoma (NHL), this pilot study was designed to investigate the impact of CD38 (184C/G; rs6449182) and IL-6 (-174 G/C; rs1800795) gene polymorphism on susceptibility of Egyptians to diffuse large B cell lymphoma (DLBCL); major types of NHL.
|
25564959 |
2015 |
|
Adult Hodgkin Lymphoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Subgroup analysis indicated that rs1800795 was significantly associated with increased risk of cervical cancer, colorectal cancer, breast cancer, prostate cancer, lung cancer, glioma, non-Hodgkin's lymphoma and Hodgkin's lymphoma but not gastric cancer and multiple myeloma.
|
29552316 |
2018 |
|
Adult Hodgkin Lymphoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The IL-6 promoter rs1800795 conferred protection against young adult Hodgkin's disease (ORG 0.68, 95%CI 0.48-0.95).
|
24059848 |
2013 |
|
Adult Liver Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subgroup analyses of rs1800797 also suggested non-significant association and rs1800795 played a protective role in liver cancer.
|
29842912 |
2018 |
|
African Burkitt's lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Using case-control samples from western Kenya consisting of 117 eBL cases and 88 ethnically matched healthy controls, we tested for the association between eBL risk and IL-10 (rs1800896, rs1800871, and rs1800872) and IL-6 (rs1800795) promoter single nucleotide polymorphisms (SNPs) as well as IL-10 promoter haplotypes.
|
25071000 |
2014 |
|
Allergic rhinitis (disorder)
|
|
0.020 |
GeneticVariation
|
BEFREE |
Multivariate logistic regression analyses revealed that individuals with the C allele of IL-6 rs1800795 were susceptible to increased risk of all</span>ergic rhinitis, compared to those expressing the G allele (adjusted OR = 1.31; 95%CI = 1.01-1.68).
|
26909898 |
2016 |
|
Allergic rhinitis (disorder)
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found that two promotor variants in IL-6, especially rs1800795, were predisposing factors for AR with a negative heterosis pattern.
|
24974143 |
2014 |
|
Alzheimer's Disease
|
|
0.720 |
GeneticVariation
|
BEFREE |
In this case-control study, we aimed to investigate whether single nucleotide polymorphisms in the BIN1 (rs744373) and IL-6 (rs1800795) genes are associated with AD.
|
26733302 |
2016 |
|
Alzheimer's Disease
|
|
0.720 |
GeneticVariation
|
GWASCAT |
A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin.
|
26545630 |
2016 |
|
Alzheimer's Disease
|
|
0.720 |
GeneticVariation
|
BEFREE |
Regression analysis revealed that the presence of both rs1801133 T and rs1800795 C alleles increased the odds of developing AD by 2.5 and VaD by 3.7-fold.
|
22015309 |
2012 |
|
Androgen-Insensitivity Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study did not find any significant association of promoter polymorphisms of the MMP-3 (-1171 5A/6A rs3025058) and IL-6 gene (-174G/C rs1800795) with AIS.
|
20436380 |
2010 |
|
Anthracosilicosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Associations of polymorphisms in the cytokine genes IL1β (rs16944), IL6 (rs1800795), IL12b (rs3212227) and growth factor VEGFA (rs2010963) with anthracosilicosis in coal miners in Russia and related genotoxic effects.
|
29378067 |
2018 |
|
Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated whether the functional G174C polymorphism (rs1800795) of interleukin-6 gene is associated with vital exhaustion, a measure of chronic stress, or with preclinical atherosclerosis.
|
24630186 |
2014 |
|
Atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated whether the functional G174C polymorphism (rs1800795) of interleukin-6 gene is associated with vital exhaustion, a measure of chronic stress, or with preclinical atherosclerosis.
|
24630186 |
2014 |
|
Atrial Fibrillation
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphisms in PITX2 (rs2200733) and IL6 (rs1800795) are associated with postoperative atrial fibrillation in adults but have not been studied in CHD.
|
29800783 |
2018 |
|
Autoimmune Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs1800795 gene polymorphism of IL-6 is associated with various autoimmune diseases, like multiple sclerosis.
|
26640809 |
2015 |
|
Bacteremia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Associations were found between the CC genotype of IL6 SNP rs1800795 and occurrence of bacteremia and between TLR5 SNP rs5744168 and protection from UTI.
|
25807366 |
2015 |
|
Benign Prostatic Hyperplasia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The A C haplotype (rs2069845 and rs1800795 respectively) was associated with PCa and BPH risk (OR (95% CI) = 1.67 (1.12- 2.48); OR (95% CI)= 1.78 (1.25 - 2.54)).
|
30345492 |
2019 |