|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Further studies of the Pro12Ala variant will determine its relevance to obesity, insulin resistance, and type 2 diabetes.
|
9425261 |
1997 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further studies of the Pro12Ala variant will determine its relevance to obesity, insulin resistance, and type 2 diabetes.
|
9425261 |
1997 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was also no significant relationship between dyslipoproteinemia or obesity and the PPARgamma2 Pro12Ala genotype.
|
9918859 |
1999 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Pro12Ala missense mutation of the peroxisome proliferator activated receptor gamma and diabetes mellitus.
|
9918859 |
1999 |
|
Hyperinsulinism
|
|
0.090 |
GeneticVariation
|
BEFREE |
The PPARgamma2 amino acid polymorphism Pro 12 Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects.
|
10382597 |
1999 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Although the study was carried out on a sufficiently large sample, the conclusions do not support a major role for the Pro12Ala substitution of the PPAR-gamma gene in the etiology of type 2 diabetes.
|
10389855 |
1999 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
These results suggest that the PPARgamma is a thrifty gene and that the Pro12Ala PPARgamma2 polymorphism protects against type 2 diabetes in the Japanese.
|
10777704 |
2000 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that the Pro</span>12Ala mutation in PPARgamma is not associated with either diabetes or obesity and may not be an important determinant of obesity or diabetes in Korean subjects.
|
10843155 |
2000 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that the Pro12Ala mutation in PPARgamma is not associated with either diabetes or obesity and may not be an important determinant of obesity or diabetes in Korean subjects.
|
10843155 |
2000 |
|
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that the Pro12Ala mutation in PPARgamma is not associated with either diabetes or obesity and may not be an important determinant of obesity or diabetes in Korean subjects.
|
10843155 |
2000 |
|
Impaired glucose tolerance
|
|
0.040 |
GeneticVariation
|
BEFREE |
Allele frequencies of the Pro12Ala missense mutation of PPARgamma2 were not different among Korean subjects with normal glucose tolerance (qAla = 0.045), those with impaired glucose tolerance (qAla = 0.033), and those with diabetes mellitus (qAla = 0.043; P > 0.05).
|
10843155 |
2000 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Peroxisome proliferator-activated receptor-gamma2 P12A and type 2 diabetes in Canadian Oji-Cree.
|
10843190 |
2000 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among obese women, the Pro12Ala mutation lowered age of obesity onset (Pro/Pro, 13.2 +/- 9.
|
10873398 |
2000 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
We were able to confirm only one association, that of the common Pro12Ala polymorphism in peroxisome proliferator-activated receptor-gamma(PPARgamma) with type 2 diabetes.
|
10973253 |
2000 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
These results suggest that in the Taiwanese, the Pro12Ala PPARgamma2 gene variant may contribute to fat accumulation and a higher BMI independent of type 2 diabetes.
|
11079814 |
2000 |
|
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
When these 6 traits were included in a multivariate analysis, body mass index, systolic and diastolic blood pressures, triglyceride levels, and glucose concentration remained significantly associated with the P12A variant (P < 0.05), whereas the effect of P12A on liability for diabetes was not significant.
|
11158005 |
2001 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
When these 6 traits were included in a multivariate analysis, body mass index, systolic and diastolic blood pressures, triglyceride levels, and glucose concentration remained significantly associated with the P12A variant (P < 0.05), whereas the effect of P12A on liability for diabetes was not significant.
|
11158005 |
2001 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effect of the peroxisome proliferator-activated receptor-gamma 2 pro(12)ala variant on obesity, glucose homeostasis, and blood pressure in members of familial type 2 diabetic kindreds.
|
11158005 |
2001 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
We confirm an association of the P12A variant in traits commonly ascribed to the insulin resistance syndrome, but not with direct measures of insulin sensitivity.
|
11158005 |
2001 |
|
Insulin resistance syndrome
|
|
0.040 |
GeneticVariation
|
BEFREE |
We confirm an association of the P12A variant in traits commonly ascribed to the insulin resistance syndrome, but not with direct measures of insulin sensitivity.
|
11158005 |
2001 |
|
Dyslipidemias
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Pro(12)Ala (P12A) variant of exon B of the peroxisome proliferator-activated receptor gamma(2) (PPAR gamma) been variably associated with obesity, insulin sensitivity, diabetes, and dyslipidemia, but its role in insulin resistance-associated traits remains uncertain.
|
11158005 |
2001 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro12Ala polymorphism is not directly associated with obesity, hypertension or diabetes in this population.
|
11248748 |
2001 |
|
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro12Ala polymorphism is not directly associated with obesity, hypertension or diabetes in this population.
|
11248748 |
2001 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro12Ala polymorphism is not directly associated with obesity, hypertension or diabetes in this population.
|
11248748 |
2001 |
|
Hypertensive disease
|
|
0.070 |
GeneticVariation
|
BEFREE |
The Pro12Ala polymorphism is not directly associated with obesity, hypertension or diabetes in this population.
|
11248748 |
2001 |