|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
(1) To determine the allele and genotype frequency of the Pro12Ala PPARgamma2 amino acid variant in a Polish population; (2) To search for the association of the Pro12Ala polymorphism with T2DM in the examined population.
|
14581147 |
2003 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Diabetes risk alleles in PPAR-γ2 (rs1801282) and PTPRD (rs17584499) are associated with pioglitazone therapeutic efficacy.
|
23147557 |
2013 |
|
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
Diabetes risk alleles in PPAR-γ2 (rs1801282) and PTPRD (rs17584499) are associated with pioglitazone therapeutic efficacy.
|
23147557 |
2013 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Obesity and Pro12Ala Polymorphism of Peroxisome Proliferator-Activated Receptor-Gamma Gene in Healthy Adults: A Systematic Review and Meta-Analysis.
|
26361038 |
2015 |
|
Impaired cognition
|
|
0.060 |
GeneticVariation
|
BEFREE |
Cognitive decline and the PPAR-γ Pro12Ala genotype: variation by sex and ethnicity.
|
28181642 |
2017 |
|
Mental deterioration
|
|
0.040 |
GeneticVariation
|
BEFREE |
Cognitive decline and the PPAR-γ Pro12Ala genotype: variation by sex and ethnicity.
|
28181642 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma is associated with increased leptin levels in women with type-2 diabetes mellitus.
|
12218380 |
2002 |
|
Malignant Neoplasms
|
|
0.070 |
GeneticVariation
|
BEFREE |
Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) gene and risk of prostate cancer among men in a large cancer prevention study.
|
12609711 |
2003 |
|
Primary malignant neoplasm
|
|
0.070 |
GeneticVariation
|
BEFREE |
Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) gene and risk of prostate cancer among men in a large cancer prevention study.
|
12609711 |
2003 |
|
Rectal Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
P12A PPARgamma did not significantly interact with BMI, WHR, energy intake, and energy expenditure to alter risk of colon or rectal cancer.
|
15860437 |
2005 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Pro12Ala polymorphism of the PPARG2 gene is associated with type 2 diabetes mellitus and peripheral insulin sensitivity in a population with a high intake of oleic acid.
|
16920849 |
2006 |
|
Diabetic Nephropathy
|
|
0.060 |
GeneticVariation
|
BEFREE |
Pro12Ala polymorphism in the PPARG gene contributes to the development of diabetic nephropathy in Chinese type 2 diabetic patients.
|
19837787 |
2010 |
|
Hyperinsulinism
|
|
0.090 |
GeneticVariation
|
BEFREE |
Pro12Ala, a missense mutation in exon 2 of PPARG, reduces transcriptional activity of PPARgamma2 and is shown to be associated with increased insulin sensitivity and protection from T2D.
|
20368233 |
2010 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Pro12Ala PPAR γ2 gene polymorphism in PCOS women: the role of compounds regulating satiety.
|
21827375 |
2012 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Pro12Ala polymorphism was significantly associated with the susceptibility of PCOS (odds ratio [OR] 0.74, 95 % confidence interval [CI] [0.61, 0.90] for allele; OR 0.70, 95 % CI [0.57, 0.86] for genotype).
|
22527903 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Pro12Ala mutation decreases PPARG activity and resistance to NIDDM.
|
22937051 |
2012 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Pro12Ala polymorphism of PPARγ showed significant association with decreased PCOS susceptibility.
|
23748472 |
2013 |
|
Malignant neoplasm of breast
|
|
0.070 |
GeneticVariation
|
BEFREE |
Pro 12Ala and Ala203Pro polymorphisms did not modify the association between the iAs methylation capacity and BC.
|
27557380 |
2016 |
|
Breast Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Pro 12Ala and Ala203Pro polymorphisms did not modify the association between the iAs methylation capacity and BC.
|
27557380 |
2016 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Pro12Ala missense mutation of the peroxisome proliferator activated receptor gamma and diabetes mellitus.
|
9918859 |
1999 |
|
Hyperinsulinism
|
|
0.090 |
GeneticVariation
|
BEFREE |
A common polymorphism (Pro12Ala) of the adipose tissue-specific gamma 2 isoform is associated with increased insulin sensitivity and decreased risk of developing type 2 diabetes.
|
12643137 |
2002 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
A common polymorphism (Pro12Ala) of the adipose tissue-specific gamma 2 isoform is associated with increased insulin sensitivity and decreased risk of developing type 2 diabetes.
|
12643137 |
2002 |
|
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer.
|
16393309 |
2006 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer.
|
16393309 |
2006 |
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer.
|
16393309 |
2006 |