|
Malignant neoplasm of breast
|
|
0.720 |
CausalMutation
|
CLINVAR |
Heterozygous mutations in the PALB2 hereditary breast cancer predisposition gene impact on the three-dimensional nuclear organization of patient-derived cell lines.
|
23341105 |
2013 |
|
Malignant neoplasm of breast
|
|
0.720 |
GeneticVariation
|
BEFREE |
We also identified a PALB2 p.</span>Q775X carrier who had papillary serous ovarian cystadenocarcinoma at age 58 among the 238 serous subtype ovarian cancer cases investigated, who also had breast cancer at age 52.
|
23302520 |
2013 |
|
Malignant neoplasm of breast
|
|
0.720 |
CausalMutation
|
CLINVAR |
We also identified a PALB2 p.Q775X carrier who had papillary serous ovarian cystadenocarcinoma at age 58 among the 238 serous subtype ovarian cancer cases investigated, who also had breast cancer at age 52.
|
23302520 |
2013 |
|
Malignant neoplasm of breast
|
|
0.720 |
GeneticVariation
|
BEFREE |
One c.9004G>A carrier also harbored the PALB2 c.2323C>T (Q775X) mutation found to recur in French Canadian breast cancer cases.
|
21947752 |
2012 |
|
Malignant neoplasm of breast
|
|
0.720 |
CausalMutation
|
CLINVAR |
One c.9004G>A carrier also harbored the PALB2 c.2323C>T (Q775X) mutation found to recur in French Canadian breast cancer cases.
|
21947752 |
2012 |
|
Malignant neoplasm of breast
|
|
0.720 |
CausalMutation
|
CLINVAR |
The contribution of founder mutations to early-onset breast cancer in French-Canadian women.
|
19863560 |
2009 |
|
Malignant neoplasm of breast
|
|
0.720 |
CausalMutation
|
CLINVAR |
Identification of a novel truncating PALB2 mutation and analysis of its contribution to early-onset breast cancer in French-Canadian women.
|
18053174 |
2007 |
|
Neoplastic Syndromes, Hereditary
|
|
0.700 |
CausalMutation
|
CLINVAR |
Contribution of the PALB2 c.2323C>T [p.Q775X] founder mutation in well-defined breast and/or ovarian cancer families and unselected ovarian cancer cases of French Canadian descent.
|
23302520 |
2013 |
|
Neoplastic Syndromes, Hereditary
|
|
0.700 |
CausalMutation
|
CLINVAR |
Heterozygous mutations in the PALB2 hereditary breast cancer predisposition gene impact on the three-dimensional nuclear organization of patient-derived cell lines.
|
23341105 |
2013 |
|
Neoplastic Syndromes, Hereditary
|
|
0.700 |
CausalMutation
|
CLINVAR |
Identification of a novel truncating PALB2 mutation and analysis of its contribution to early-onset breast cancer in French-Canadian women.
|
18053174 |
2007 |
|
BREAST CANCER, SUSCEPTIBILITY TO
|
|
0.700 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
|
Breast Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We also identified a PALB2 p.</span>Q775X carrier who had papillary serous ovarian cystadenocarcinoma at age 58 among the 238 serous subtype ovarian cancer cases investigated, who also had breast cancer at age 52.
|
23302520 |
2013 |
|
Breast Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
One c.9004G>A carrier also harbored the PALB2 c.2323C>T (Q775X) mutation found to recur in French Canadian breast cancer cases.
|
21947752 |
2012 |
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings, taken together with previous reports, support adding PALB2 c.2323C>T p.Q775X to the list of cancer susceptibility genes for which founder mutations have been identified in the French Canadian population.
|
23302520 |
2013 |
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
We screened the PALB2 p.Q775X variant in 71 families with at least three cases of breast cancer (n=48) or breast and ovarian cancers (n=23) that have previously been found negative for at least the most common BRCA1 and BRCA2 mutations reported in the French Canadian population and in 491 women of French Canadian descent who had invasive ovarian cancer and/or low malignant potential tumors of the major histopathological subtypes.
|
23302520 |
2013 |
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings, taken together with previous reports, support adding PALB2 c.2323C>T p.Q775X to the list of cancer susceptibility genes for which founder mutations have been identified in the French Canadian population.
|
23302520 |
2013 |