|
Cervix carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
CC and CT genotypes of TLR4 rs11536889 and rs1927911 respectively, and TC, CC genotypes of TLR9 rs187084, as well as minor alleles of TLR4 rs4986790 and TLR9 rs187084, were associated with the increased risk of cervical cancer.
|
31278284 |
2019 |
|
Malignant tumor of cervix
|
|
0.050 |
GeneticVariation
|
BEFREE |
CC and CT genotypes of TLR4 rs11536889 and rs1927911 respectively, and TC, CC genotypes of TLR9 rs187084, as well as minor alleles of TLR4 rs4986790 and TLR9 rs187084, were associated with the increased risk of cervical cancer.
|
31278284 |
2019 |
|
cervical cancer
|
|
0.050 |
GeneticVariation
|
BEFREE |
CC and CT genotypes of TLR4 rs11536889 and rs1927911 respectively, and TC, CC genotypes of TLR9 rs187084, as well as minor alleles of TLR4 rs4986790 and TLR9 rs187084, were associated with the increased risk of cervical cancer.
|
31278284 |
2019 |
|
cervical cancer
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our results revealed that the associations between rs187084</span> and ce</span>rvical cancer risk in the dominant model (<i>p</i> = 0.002) and heterozygous model (<i>p</i> = 0.002) were significant, with 1.30- and 1.32-fold increases in susceptibility, respectively, compared to that in the wild-type model.
|
30147445 |
2018 |
|
Malignant tumor of cervix
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our results revealed that the associations between rs187084</span> and ce</span>rvical cancer risk in the dominant model (<i>p</i> = 0.002) and heterozygous model (<i>p</i> = 0.002) were significant, with 1.30- and 1.32-fold increases in susceptibility, respectively, compared to that in the wild-type model.
|
30147445 |
2018 |
|
Cervix carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our results revealed that the associations between rs187084</span> and ce</span>rvical cancer risk in the dominant model (<i>p</i> = 0.002) and heterozygous model (<i>p</i> = 0.002) were significant, with 1.30- and 1.32-fold increases in susceptibility, respectively, compared to that in the wild-type model.
|
30147445 |
2018 |
|
Lupus Erythematosus, Systemic
|
|
0.050 |
GeneticVariation
|
BEFREE |
In conclusion, the meta-analysis results suggested that TLR9 rs187084 polymorphism may increase the risk of SLE in Asians.
|
26643792 |
2016 |
|
Lupus Erythematosus, Systemic
|
|
0.050 |
GeneticVariation
|
BEFREE |
The meta-analysis showed no association between the two alleles of the rs352140, rs5743836, and rs352139 polymorphisms of TLR9 and SLE, but indicated an association between the two alleles of the rs187084 polymorphism (TLR9) and SLE in the overall population (OR = 0.869, 95% CI = 0.762-0.992, P = 0.038).
|
26762473 |
2016 |
|
Malignant tumor of cervix
|
|
0.050 |
GeneticVariation
|
BEFREE |
This meta-analysis indicates that TLR9 (-1486T/C, rs187084)-but not TLR9 (2848G/A, rs352140)-may be a risk factor for cervical cancer.
|
26270118 |
2015 |
|
cervical cancer
|
|
0.050 |
GeneticVariation
|
BEFREE |
This meta-analysis indicates that TLR9 (-1486T/C, rs187084)-but not TLR9 (2848G/A, rs352140)-may be a risk factor for cervical cancer.
|
26270118 |
2015 |
|
Cervix carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
This meta-analysis indicates that TLR9 (-1486T/C, rs187084)-but not TLR9 (2848G/A, rs352140)-may be a risk factor for cervical cancer.
|
26270118 |
2015 |
|
Malignant tumor of cervix
|
|
0.050 |
GeneticVariation
|
BEFREE |
The results showed that the rs187084 polymorphism was significantly associated with an increased risk of cancer (CC vs TC+TT: OR=1.14, 95% CI=1.02-1.28), specifically cervical cancer (C vs T: OR=1.19, 95% CI=1.05-1.34; TC vs TT: OR=1.32, 95% CI=1.10-1.58; CC vs TT: OR=1.31, 95% CI= 1.03-1.68; CC+TC vs TT: OR=1.32, 95% CI=1.11-1.56), and that this association was significantly positive in Caucasians (CC vs. TC+TT: OR=1.18, 95% CI=1.01-1.38).
|
25339018 |
2014 |
|
cervical cancer
|
|
0.050 |
GeneticVariation
|
BEFREE |
The results showed that the rs187084 polymorphism was significantly associated with an increased risk of cancer (CC vs TC+TT: OR=1.14, 95% CI=1.02-1.28), specifically cervical cancer (C vs T: OR=1.19, 95% CI=1.05-1.34; TC vs TT: OR=1.32, 95% CI=1.10-1.58; CC vs TT: OR=1.31, 95% CI= 1.03-1.68; CC+TC vs TT: OR=1.32, 95% CI=1.11-1.56), and that this association was significantly positive in Caucasians (CC vs. TC+TT: OR=1.18, 95% CI=1.01-1.38).
|
25339018 |
2014 |
|
Cervix carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
The results showed that the rs187084 polymorphism was significantly associated with an increased risk of cancer (CC vs TC+TT: OR=1.14, 95% CI=1.02-1.28), specifically cervical cancer (C vs T: OR=1.19, 95% CI=1.05-1.34; TC vs TT: OR=1.32, 95% CI=1.10-1.58; CC vs TT: OR=1.31, 95% CI= 1.03-1.68; CC+TC vs TT: OR=1.32, 95% CI=1.11-1.56), and that this association was significantly positive in Caucasians (CC vs. TC+TT: OR=1.18, 95% CI=1.01-1.38).
|
25339018 |
2014 |
|
Malignant tumor of cervix
|
|
0.050 |
GeneticVariation
|
BEFREE |
Logistic regression analyses showed that the rs187</span>084 heterozygote TC was associated with a significantly increased risk of cervical cancer (adjusted OR=1.28, 95% CI=1.01-1.62), compared with the TT genotype.
|
22059466 |
2012 |
|
Lupus Erythematosus, Systemic
|
|
0.050 |
GeneticVariation
|
BEFREE |
However, for the genotype of TLR9 -1486 T/C (rs187084) polymorphism, there was a statistically significant difference between the SLE and the control groups (P < 0.001, χ(2) = 15.9).
|
21499878 |
2012 |
|
Lupus Erythematosus, Systemic
|
|
0.050 |
GeneticVariation
|
BEFREE |
Furthermore, no association was found between the rs5744168 (TLR5) polymorphism and SLE susceptibility in Europeans or between the rs187084 (TLR8) or rs352140 (TLR9) polymorphisms and SLE susceptibility in Asians.
|
22325161 |
2012 |
|
Cervix carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Logistic regression analyses showed that the rs187</span>084 heterozygote TC was associated with a significantly increased risk of cervical cancer (adjusted OR=1.28, 95% CI=1.01-1.62), compared with the TT genotype.
|
22059466 |
2012 |
|
Lupus Erythematosus, Systemic
|
|
0.050 |
GeneticVariation
|
BEFREE |
When available studies were pooled into the meta-analysis, there was no evidence showing a significant association between rs187084 and SLE risk in an Asian population (for C vs. T: OR = 0.81, P = 0.117; for CC vs. TT: OR = 0.71, P = 0.158; for CT vs. TT: OR = 0.86, P = 0.085; for CC + CT vs. TT: OR = 0.78, P = 0.093; for CC vs. CT + TT: OR = 0.81, P = 0.285).
|
22228476 |
2012 |
|
cervical cancer
|
|
0.050 |
GeneticVariation
|
BEFREE |
Logistic regression analyses showed that the rs187</span>084 heterozygote TC was associated with a significantly increased risk of cervical cancer (adjusted OR=1.28, 95% CI=1.01-1.62), compared with the TT genotype.
|
22059466 |
2012 |
|
Malignant Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
Stage-wise analysis revealed TLR9 rs187084 and rs352140 to be associated with early-stage cancer.
|
31278284 |
2019 |
|
Primary malignant neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
Stage-wise analysis revealed TLR9 rs187084 and rs352140 to be associated with early-stage cancer.
|
31278284 |
2019 |
|
Tuberculosis, Pulmonary
|
|
0.030 |
GeneticVariation
|
BEFREE |
The G allele of TLR9 SNP rs187084 was found to increase the risk of PTB (G vs A, P = 0.01, OR = 1.48, 95% CI = 1.10-2.00), the significance was also observed under dominant genetic models.
|
30424735 |
2018 |
|
Tuberculosis, Pulmonary
|
|
0.030 |
GeneticVariation
|
BEFREE |
BACKGROUND Findings regarding the association of the single-nucleotide polymorphisms (SNPs) rs4986790 and rs4986791 in Toll-like receptor 4 and rs187084, rs574386, and rs352139 in Toll-like receptor 9 (TLR9) with pulmonary tuberculosis (PTB) susceptibility are inconsistent.
|
25889916 |
2015 |
|
Tuberculosis, Pulmonary
|
|
0.030 |
GeneticVariation
|
BEFREE |
Collectively, these data suggest that the minor "C" allele at rs187084 locus may be associated with susceptibility to PTB, which may explain the relatively lower PTB rates observed in Baiga tribe members.
|
25248338 |
2014 |