|
Osteoporosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Women with the TT genotype in rs1883832 SNP affecting to Kozak consensus sequence of CD40 gene had lower BMD at FN and at LS sites and increased risk of osteopenia or osteoporosis.
|
18097708 |
2008 |
|
Osteopenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Women with the TT genotype in rs1883832 SNP affecting to Kozak consensus sequence of CD40 gene had lower BMD at FN and at LS sites and increased risk of osteopenia or osteoporosis.
|
18097708 |
2008 |
|
Adult Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We hypothesized that single nucleotide polymorphisms (SNPs) in TNFRSF5 and TNFSF5 encoding the CD40 and CD154 proteins, respectively, influence lymphoma risk, particularly a functional TNFRSF5 SNP (-1C>T, rs1883832) associated with reduced B-cell CD40 expression.
|
18287517 |
2008 |
|
Childhood Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We hypothesized that single nucleotide polymorphisms (SNPs) in TNFRSF5 and TNFSF5 encoding the CD40 and CD154 proteins, respectively, influence lymphoma risk, particularly a functional TNFRSF5 SNP (-1C>T, rs1883832) associated with reduced B-cell CD40 expression.
|
18287517 |
2008 |
|
Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We hypothesized that single nucleotide polymorphisms (SNPs) in TNFRSF5 and TNFSF5 encoding the CD40 and CD154 proteins, respectively, influence lymphoma risk, particularly a functional TNFRSF5 SNP (-1C>T, rs1883832) associated with reduced B-cell CD40 expression.
|
18287517 |
2008 |
|
Lymphoma, Follicular
|
|
0.010 |
GeneticVariation
|
BEFREE |
Data from earlier studies that are part of this pooling study implicate a functional polymorphism (-1C>T, rs1883832) in the TNFRSF5 gene encoding CD40 in the etiology of follicular lymphoma.
|
20473910 |
2011 |
|
Ischemic stroke
|
|
0.030 |
GeneticVariation
|
BEFREE |
CD40-1C>T polymorphism (rs1883832) is associated with brain vessel reocclusion after fibrinolysis in ischemic stroke.
|
20504251 |
2010 |
|
Crohn Disease
|
|
0.720 |
GeneticVariation
|
BEFREE |
The impact of CD40 rs1883832 on MS and CD risk points to a common signaling shared by these autoimmune conditions.
|
20634952 |
2010 |
|
Ulcerative Colitis
|
|
0.720 |
GeneticVariation
|
BEFREE |
Genotyping of rs1883832C>T was performed in 1564 MS, 1102 CD and 969 ulcerative colitis (UC) Spanish patients and in 2948 ethnically matched controls by TaqMan chemistry.
|
20634952 |
2010 |
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The impact of CD40 rs1883832 on MS and CD risk points to a common signaling shared by these autoimmune conditions.
|
20634952 |
2010 |
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Genotyping of rs1883832C>T was performed in 1564 MS, 1102 CD and 969 ulcerative colitis (UC) Spanish patients and in 2948 ethnically matched controls by TaqMan chemistry.
|
20634952 |
2010 |
|
Giant Cell Arteritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results suggest a potential implication of the CD40 rs1883832 C/T polymorphism in susceptibility to visual ischemic manifestations in individuals with biopsy-proven GCA.
|
20682661 |
2010 |
|
Autoimmune Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
A functional polymorphism (-1C>T, rs1883832) in the 5' untranslated region of TNFRSF5 gene has been reported to affect CD40 expression and be associated with several chronic inflammatory and autoimmune diseases.
|
21091218 |
2011 |
|
Acute Chest Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
The distribution of the rs1883832 genotypes (CC, CT, and TT) was 33.1%, 54.4%, and 12.5% in the ACS group and 22.8%, 53.3%, and 23.9% in controls, respectively.
|
21091218 |
2011 |
|
Acute Coronary Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
The CD40 gene polymorphism rs1883832 is associated with risk of acute coronary syndrome in a Chinese case-control study.
|
21091218 |
2011 |
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, our haplotype analysis indicated that the haplotype C(rs1883832)G(rs4810485), which was located within the only linkage disequilibrium (LD) block identified, was a protective haplotype for breast cancer, whereas T(rs1883832)T(rs4810485) increased the risk in the studied population, even after correcting the P value for multiple testing (P = 0.0337 and 0.0430, respectively).
|
21912605 |
2011 |
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, our haplotype analysis indicated that the haplotype C(rs1883832)G(rs4810485), which was located within the only linkage disequilibrium (LD) block identified, was a protective haplotype for breast cancer, whereas T(rs1883832)T(rs4810485) increased the risk in the studied population, even after correcting the P value for multiple testing (P = 0.0337 and 0.0430, respectively).
|
21912605 |
2011 |
|
Sarcoidosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Genotyping of rs1883832 in 175 Japanese patients with sarcoidosis and 150 age- and sex-matched controls revealed no significant difference between the genotypes of the patient and control groups (CC/CT/TT, 32.8/52.0/14.7% in the patients; 37.3/48.0/14.7% in the controls, P = 0.66; allele C, 59.1% in the patients, 61.3% in the controls, P = 0.57).
|
22077624 |
2011 |
|
Behcet Syndrome
|
|
0.030 |
GeneticVariation
|
BEFREE |
The results suggest that TT genotypes of rs4810485 and rs1883832 may be predisposing genotypes for BD, and that the rs4810485 GT genotype may be a protective genotype for BD.
|
22087016 |
2012 |
|
Rheumatoid Arthritis
|
|
0.730 |
GeneticVariation
|
BEFREE |
Data from our pilot study indicate a potential association of rs1883832 CD40 gene polymorphism with susceptibility to RA.
|
23166616 |
2012 |
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
From our analysis, we can speculate that the association between rs1883832 and MS was induced by LD, whereas rs6074022 was a marker in stronger LD with the functional variant or was the functional variant itself.
|
23613777 |
2013 |
|
Rheumatoid Arthritis
|
|
0.730 |
GeneticVariation
|
GWASCAT |
High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.
|
24532676 |
2015 |
|
Ischemic stroke
|
|
0.030 |
GeneticVariation
|
BEFREE |
This meta-analysis provided evidence of association of rs1883832 C allele with an overall increased risk of atherosclerosis but distinct effect of C allele on CAD (including ACS) and IS in Chinese population, respectively.
|
24828072 |
2014 |
|
Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
This meta-analysis provided evidence of association of rs1883832 C allele with an overall increased risk of atherosclerosis but distinct effect of C allele on CAD (including ACS) and IS in Chinese population, respectively.
|
24828072 |
2014 |
|
Acute Chest Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
This meta-analysis provided evidence of association of rs1883832 C allele with an overall increased risk of atherosclerosis but distinct effect of C allele on CAD (including ACS) and IS in Chinese population, respectively.
|
24828072 |
2014 |