|
Rheumatoid Arthritis
|
|
0.730 |
GeneticVariation
|
BEFREE |
CD40 rs1883832 is associated with decreased risk of Graves' disease, especially in Asian; CD40 rs1883832 is associated with increased risk of multiple sclerosis; CD40 -1C>T (rs1883832) is not associated with the susceptibility of Hashimoto's thyroiditis, systemic sclerosis or Asthma; there is insufficient data to fully confirm the association between CD40 rs1883832 and systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Behçet's disease (BD), myasthenia gravis (MG), Crohn's disease (CD), ulcerative colitis (UC), Sarcoidosis, Fuch uveitis syndrome (FUS), Vogt-Koyanagi-Harada syndrome (VKH), Kawasaki disease (KD), giant cell arteritis (GCA) or Immune thrombocytopenia (ITP).
|
29254239 |
2017 |
|
Rheumatoid Arthritis
|
|
0.730 |
GeneticVariation
|
BEFREE |
These results suggest that the CD40 SNPs rs1883832 and rs4810485 are not RA susceptibility markers in the western Mexican population.
|
27813548 |
2016 |
|
Rheumatoid Arthritis
|
|
0.730 |
GeneticVariation
|
GWASCAT |
High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.
|
24532676 |
2015 |
|
Rheumatoid Arthritis
|
|
0.730 |
GeneticVariation
|
BEFREE |
Data from our pilot study indicate a potential association of rs1883832 CD40 gene polymorphism with susceptibility to RA.
|
23166616 |
2012 |
|
Crohn Disease
|
|
0.720 |
GeneticVariation
|
BEFREE |
CD40 rs1883832 is associated with decreased risk of Graves' disease, especially in Asian; CD40 rs1883832 is associated with increased risk of multiple sclerosis; CD40 -1C>T (rs1883832) is not associated with the susceptibility of Hashimoto's thyroiditis, systemic sclerosis or Asthma; there is insufficient data to fully confirm the association between CD40 rs1883832 and systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Behçet's disease (BD), myasthenia gravis (MG), Crohn's disease (CD), ulcerative colitis (UC), Sarcoidosis, Fuch uveitis syndrome (FUS), Vogt-Koyanagi-Harada syndrome (VKH), Kawasaki disease (KD), giant cell arteritis (GCA) or Immune thrombocytopenia (ITP).
|
29254239 |
2017 |
|
Ulcerative Colitis
|
|
0.720 |
GeneticVariation
|
BEFREE |
CD40 rs1883832 is associated with decreased risk of Graves' disease, especially in Asian; CD40 rs1883832 is associated with increased risk of multiple sclerosis; CD40 -1C>T (rs1883832) is not associated with the susceptibility of Hashimoto's thyroiditis, systemic sclerosis or Asthma; there is insufficient data to fully confirm the association between CD40 rs1883832 and systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Behçet's disease (BD), myasthenia gravis (MG), Crohn's disease (CD), ulcerative colitis (UC), Sarcoidosis, Fuch uveitis syndrome (FUS), Vogt-Koyanagi-Harada syndrome (VKH), Kawasaki disease (KD), giant cell arteritis (GCA) or Immune thrombocytopenia (ITP).
|
29254239 |
2017 |
|
Crohn Disease
|
|
0.720 |
GeneticVariation
|
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Ulcerative Colitis
|
|
0.720 |
GeneticVariation
|
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Crohn Disease
|
|
0.720 |
GeneticVariation
|
BEFREE |
The impact of CD40 rs1883832 on MS and CD risk points to a common signaling shared by these autoimmune conditions.
|
20634952 |
2010 |
|
Ulcerative Colitis
|
|
0.720 |
GeneticVariation
|
BEFREE |
Genotyping of rs1883832C>T was performed in 1564 MS, 1102 CD and 969 ulcerative colitis (UC) Spanish patients and in 2948 ethnically matched controls by TaqMan chemistry.
|
20634952 |
2010 |
|
Cholangitis, Sclerosing
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Ankylosing spondylitis
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Psoriasis
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Hepatitis B, Chronic
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B.
|
25802187 |
2015 |
|
Lupus Erythematosus, Systemic
|
|
0.060 |
GeneticVariation
|
BEFREE |
The study did not prove CD40 gene (rs1883832 C/T) polymorphism as a clear risk factor of SLE in this cohort of Egyptian patients, though it was highly likely associated with the carriers of T allele.
|
30374748 |
2019 |
|
Lupus Erythematosus, Systemic
|
|
0.060 |
GeneticVariation
|
BEFREE |
The association of CD40 polymorphism (rs1883832C/T) and soluble CD40 with the risk of systemic lupus erythematosus among Egyptian patients.
|
30374748 |
2019 |
|
Lupus Erythematosus, Systemic
|
|
0.060 |
GeneticVariation
|
BEFREE |
This study aimed to evaluate the association of CD40 polymorphisms (-1 C > T, rs1883832 and 6,048 G > T, rs4810485) with SLE susceptibility, as well as with mRNA expression and soluble CD40 (sCD40) levels.
|
31642196 |
2019 |
|
Lupus Erythematosus, Systemic
|
|
0.060 |
GeneticVariation
|
BEFREE |
Furthermore, a significant association was reported between systemic lupus erythematosus and the C allele of <i>CD40</i> rs1883832 polymorphism (odds ratio = 1.235, 95% confidence interval = 1.087-1.405, <i>p</i> = 0.001) and A allele of <i>CD40</i> rs3765456 polymorphism and systemic lupus erythematosus in Asians (odds ratio = 1.184, 95% confidence interval = 1.040-1.348, <i>p</i> = 0.011). sCD40 and sCD40L levels were significantly higher in SLE than in controls (standardized mean difference = 1.564, 95% confidence interval = 0.256-2.872, <i>p</i> = 0.019 and standardized mean difference = 1.499, 95% confidence interval = 1.031-1.967, <i>p</i> < 0.001, respectively).
|
31570051 |
2019 |
|
Lupus Erythematosus, Systemic
|
|
0.060 |
GeneticVariation
|
BEFREE |
CD40 rs1883832 is associated with decreased risk of Graves' disease, especially in Asian; CD40 rs1883832 is associated with increased risk of multiple sclerosis; CD40 -1C>T (rs1883832) is not associated with the susceptibility of Hashimoto's thyroiditis, systemic sclerosis or Asthma; there is insufficient data to fully confirm the association between CD40 rs1883832 and systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Behçet's disease (BD), myasthenia gravis (MG), Crohn's disease (CD), ulcerative colitis (UC), Sarcoidosis, Fuch uveitis syndrome (FUS), Vogt-Koyanagi-Harada syndrome (VKH), Kawasaki disease (KD), giant cell arteritis (GCA) or Immune thrombocytopenia (ITP).
|
29254239 |
2017 |
|
Lupus Erythematosus, Systemic
|
|
0.060 |
GeneticVariation
|
BEFREE |
The rs1883832 C/T polymorphism of CD40 and its sCD40 levels were associated with SLE in the Chinese population.
|
26289938 |
2016 |
|
Lupus Erythematosus, Systemic
|
|
0.060 |
GeneticVariation
|
BEFREE |
Moreover, genotypes carrying the CD40 rs1883832 C/T variant allele were associated with increased CD40 levels compared to the homozygous wild-type genotype in patients with SLE.
|
26474561 |
2015 |
|
Lupus Erythematosus, Systemic
|
|
0.060 |
GeneticVariation
|
BEFREE |
There were significant differences in the genotype and allele frequencies of CD40 gene rs1883832C/T polymorphism between the group of patients with SLE and the control group (P < 0.05). sCD40 levels were increased in patients with SLE compared with controls (P < 0.01).
|
26474561 |
2015 |
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
We investigated the cell specific gene and protein expression variation controlled by the CD40 genetic variant(s) associated with MS, i.e. the T-allele at rs1883832.
|
26068105 |
2015 |
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our investigation revealed that CT individuals in rs1883832 locus of CD40 possessed almost 1.5-fold higher risk for MS than CC individuals (OR = 1.44; 95%CI = 1.03-2.1; p = 0.032), while this risk for TT individuals was almost 2.5-fold higher (OR = 2.36; 95%CI = 1.19-4.78; p = 0.014).
|
24912008 |
2014 |
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
From our analysis, we can speculate that the association between rs1883832 and MS was induced by LD, whereas rs6074022 was a marker in stronger LD with the functional variant or was the functional variant itself.
|
23613777 |
2013 |