|
Alcoholic Intoxication, Chronic
|
|
0.720 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.
|
30940813 |
2019 |
|
Alcoholic Intoxication, Chronic
|
|
0.720 |
GeneticVariation
|
BEFREE |
In a genome-wide association study (GWAS), we identified highly significant associations between two population-specific functional variants in the alcohol dehydrogenase 1B gene (ADH1B) and AD in African-Americans (AAs; rs2066702) and European-Americans (EAs; rs1229984).
|
25828809 |
2016 |
|
Alcoholic Intoxication, Chronic
|
|
0.720 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.
|
24166409 |
2014 |
|
Alcoholic Intoxication, Chronic
|
|
0.720 |
GeneticVariation
|
BEFREE |
We tested the most significant ADH1B single nucleotide polymorphisms for alcohol dependence from a genomewide association study with this sample, ADH1B-rs1229984 (Arg48His) and ADH1B-rs2066702 (Arg370Cys), in EA and AA subsamples, respectively.
|
25410943 |
2014 |
|
Alcohol-Induced Disorders
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.
|
30940813 |
2019 |
|
Alcohol-Related Disorders
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.
|
30940813 |
2019 |
|
Alcohol-Related Disorders
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.
|
24166409 |
2014 |
|
Alcohol-Induced Disorders
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.
|
24166409 |
2014 |
|
Alcohol Use Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
With longitudinal EHR data from the Million Veteran Program (MVP) linked to genetic data, we used two population-specific polymorphisms in ADH1B that are associated strongly with AUD in African Americans (AAs) and European Americans (EAs): rs2066702 (Arg369Cys, AAs) and rs1229984 (Arg48His, EAs) as criterion measures.
|
29972609 |
2018 |
|
hazardous drinking
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study investigated the association of 4 nonsynonymous SNPs in ADH genes (Arg48His and Arg370Cys in ADH1B gene; Arg272Gln and Ile350Val in ADH1C gene) with HD in people living with HIV-1.
|
28833276 |
2017 |
|
Substance Dependence
|
|
0.010 |
GeneticVariation
|
BEFREE |
Different studies have produced inconclusive results regarding association between rs1229984 (or rs2066702) and substance dependence.
|
21497796 |
2011 |
|
Withdrawal Symptoms
|
|
0.010 |
GeneticVariation
|
BEFREE |
No evidence for association with the alcohol dependence diagnosis was observed, but an SNP in exon 9 of ADH1B (rs2066702; ADH1B*3) and an SNP at the 5' end of ADH4 (rs3762894) showed significant evidence of association with the presence of withdrawal symptoms (p = 0.0018 and 0.0012, respectively).
|
21635275 |
2011 |