|
Epilepsy
|
|
0.060 |
GeneticVariation
|
BEFREE |
A significant association was found with the TT homozygous genotype and T allele for both febrile seizures and epilepsy for the C588T locus, while GABRG2 G>A 3145 showed no significant association with any type of seizure.
|
29379546 |
2018 |
|
Epilepsy
|
|
0.060 |
GeneticVariation
|
BEFREE |
The present study was designed to explore whether the GABARG2 C588 T (rs211037) genetic variant predicts susceptibility to epilepsy and pharmacoresistance among Egyptian children with Idiopathic Generalized Epilepsy (IGE).
|
29894917 |
2018 |
|
Epilepsy
|
|
0.060 |
GeneticVariation
|
BEFREE |
Rs1912960 has been associated with ASD and rs211037 with epilepsy.
|
26239769 |
2015 |
|
Epilepsy
|
|
0.060 |
GeneticVariation
|
BEFREE |
We could substantiate that among the GABA(A) receptor subunit gene cluster polymorphisms, the GABRG2, rs211037 predisposes susceptibility to epilepsy, irrespective of its phenotype, but not to AED resistance.
|
24061200 |
2013 |
|
Epilepsy
|
|
0.060 |
GeneticVariation
|
BEFREE |
Eight studies comprising 1871 epilepsy patients and 1387 controls, which evaluated association of the GABRG2 rs211037 polymorphism with susceptibility to epilepsy, were included in this meta-analysis.
|
23140995 |
2013 |
|
Epilepsy
|
|
0.060 |
GeneticVariation
|
BEFREE |
However GABRG2 588C>T polymorphism was not found to be associated either with epilepsy susceptibility or with drug resistance.
|
20356767 |
2010 |
|
Febrile Convulsions
|
|
0.050 |
GeneticVariation
|
BEFREE |
GABRG2 rs211037 TT homozygotes and T allele variants have an increased risk for developing febrile seizures.</span>
|
29379546 |
2018 |
|
Febrile Convulsions
|
|
0.050 |
GeneticVariation
|
BEFREE |
In conclusion, rs211037 alone may be a risk factor for FS, partial seizure, and SE, and in linkage disequilibrium with rs210987 can contribute to FS and SE in Asians, particularly in Chinese.
|
26452361 |
2016 |
|
Febrile Convulsions
|
|
0.050 |
GeneticVariation
|
BEFREE |
GABRG2, rs211037 is associated with epilepsy susceptibility, but not with antiepileptic drug resistance and febrile seizures.
|
24061200 |
2013 |
|
Febrile Convulsions
|
|
0.050 |
GeneticVariation
|
BEFREE |
This study showed significant association of GABRG2 rs211037 with susceptibility to FS, caused by two studies with small sample sizes, however the possibility of false positive results due to the effect of significant studies for FS cannot be excluded.
|
23140995 |
2013 |
|
Febrile Convulsions
|
|
0.050 |
GeneticVariation
|
BEFREE |
One hundred twenty-seven cases of seizure (86 GS and 41 FS) patients were analyzed for MDR1 C3435T and GABRG2 C588T gene polymorphisms using restriction fragment length polymorphism-polymerase chain reaction.Serum PHT levels were analyzed.
|
22239287 |
2012 |
|
Seizures
|
|
0.040 |
GeneticVariation
|
BEFREE |
The GABRG2 588 C > T polymorphism may decrease the duration of seizures in JME patients.
|
29785705 |
2018 |
|
Seizures
|
|
0.040 |
GeneticVariation
|
BEFREE |
A significant association was found with the TT homozygous genotype and T allele for both febrile seizures and epilepsy for the C588T locus, while GABRG2 G>A 3145 showed no significant association with any type of seizure.
|
29379546 |
2018 |
|
Seizures
|
|
0.040 |
GeneticVariation
|
BEFREE |
One hundred twenty-seven cases of seizure (86 GS and 41 FS) patients were analyzed for MDR1 C3435T and GABRG2 C588T gene polymorphisms using restriction fragment length polymorphism-polymerase chain reaction.Serum PHT levels were analyzed.
|
22239287 |
2012 |
|
Seizures
|
|
0.040 |
GeneticVariation
|
BEFREE |
The aim of our study was to find out the possible role of single nucleotide polymorphisms (SNPs) present in GABRA1 IVS11+15 A>G (rs2279020) and GABRG2 588C>T (rs211037) genes in seizure susceptibility and pharmaco-resistance in northern Indian patients with epilepsy.
|
20356767 |
2010 |
|
Juvenile Myoclonic Epilepsy
|
|
0.030 |
GeneticVariation
|
BEFREE |
The GABRG2 588 C > T polymorphism may decrease the duration of seizures in JME patients.
|
29785705 |
2018 |
|
Juvenile Myoclonic Epilepsy
|
|
0.030 |
GeneticVariation
|
BEFREE |
These results present no evidence for an association of rs211037 with JME.
|
23287319 |
2015 |
|
Juvenile Myoclonic Epilepsy
|
|
0.030 |
GeneticVariation
|
BEFREE |
A significant allelic (P=0.0006, odds ratio=1.6, 95% confidence interval=1.22-2.08) and genotypic (P=0.001) association of a synonymous variant in GABRG2, rs211037 (Asn196Asn) was observed with epilepsy irrespective of its phenotype, that is, MTLE-HS or juvenile myoclonic epilepsy.
|
24061200 |
2013 |
|
Idiopathic generalized epilepsy
|
|
0.020 |
GeneticVariation
|
BEFREE |
The genetic variant "C588T" of GABARG2 is linked to childhood idiopathic generalized epilepsy and resistance to antiepileptic drugs.
|
29894917 |
2018 |
|
Idiopathic generalized epilepsy
|
|
0.020 |
GeneticVariation
|
BEFREE |
Several studies have examined a possible link between the exonic GABRG2 rs211037 locus and susceptibility to febrile seizure (FS) and idiopathic generalized epilepsy (IGE), however results have been inconclusive.
|
23140995 |
2013 |
|
Epilepsy, Generalized
|
|
0.010 |
GeneticVariation
|
BEFREE |
This case-control study aimed to assess two single nucleotide polymorphisms of the gene encoding the GABRG2 protein - GABRG2 (3145 G>A) and GABRG2 rs 211037 Asn196Asn (C588T) - in a cohort of pediatric patients from Romania, and evaluate their possible impact on drug-resistant forms of generalized epilepsy and recurrent febrile seizures.
|
29379546 |
2018 |
|
Recurrent seizure
|
|
0.010 |
GeneticVariation
|
BEFREE |
GABRG2 C588T gene polymorphisms might be a predictive genetic marker of febrile seizures and generalized recurrent seizures: a case-control study in a Romanian pediatric population.
|
29379546 |
2018 |
|
Symptomatic epilepsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs211037-rs210987 and rs2422106-rs211014-rs401750 haplotypes we</span>re also associated with susceptibility to SE in Chinese.
|
26452361 |
2016 |
|
Seizures, Focal
|
|
0.010 |
GeneticVariation
|
BEFREE |
Results of the case-control study showed associations between rs211037 and the risk of SE in the pooled data from all cohorts (T vs. C, p = 3 × 10(-5), and TT vs. CC, p = 2 × 10(-5)) and the risk of partial seizure in the combined data of Malaysia and Hong Kong (both T vs. C and TT vs. CC, p = 2 × 10(-6)).
|
26452361 |
2016 |
|
Autism Spectrum Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
Rs1912960 has been associated with ASD and rs211037 with epilepsy.
|
26239769 |
2015 |