|
Resistant hypertensive disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the Taiwanese population, the adiponectin T94G polymorphism (r</span>s2241766) is associated with RH in YOHs.
|
30529101 |
2019 |
|
Chronic Periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Although the ADIPOQ +45G/T (rs2241766) gene variant may be a candidate biomarker for CP, further research is required in larger populations with different ethnic backgrounds before any final conclusions can be drawn about the role of this gene in CP.
|
31038568 |
2019 |
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the meta-analysis, LEP rs7799039 (allele contrast: OR 1.133, 95%CI 1.024-1.254), ADIPOQ rs2241766 (allele contrast: OR 1.201, 95%CI 1.015-1.422) and ADIPOR1 rs10920531 (allele contrast: OR 1.184, 95%CI 1.075-1.305) variants were identified to be correlated with increased risk of prostate cancer.
|
27768592 |
2016 |
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the meta-analysis, LEP rs7799039 (allele contrast: OR 1.133, 95%CI 1.024-1.254), ADIPOQ rs2241766 (allele contrast: OR 1.201, 95%CI 1.015-1.422) and ADIPOR1 rs10920531 (allele contrast: OR 1.184, 95%CI 1.075-1.305) variants were identified to be correlated with increased risk of prostate cancer.
|
27768592 |
2016 |
|
Diabetic peripheral neuropathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results show that T45G and G276T polymorphisms of ADPN are associated with a significantly elevated risk of DPN in T2DM patients, likely by down-regulating ADPN serum level.
|
26144281 |
2016 |
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Using rs2241766 as an instrument in Mendelian randomization analysis, an increment of 1 mg/L in circulating adiponectin was significantly associated with a 43-50% reduced risk for lung cancer, but with a 20-40% increased risk of colorectal cancer, respectively.
|
25273172 |
2015 |
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Using rs2241766 as an instrument in Mendelian randomization analysis, an increment of 1 mg/L in circulating adiponectin was significantly associated with a 43-50% reduced risk for lung cancer, but with a 20-40% increased risk of colorectal cancer, respectively.
|
25273172 |
2015 |
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Using rs2241766 as an instrument in Mendelian randomization analysis, an increment of 1 mg/L in circulating adiponectin was significantly associated with a 43-50% reduced risk for lung cancer, but with a 20-40% increased risk of colorectal cancer, respectively.
|
25273172 |
2015 |
|
Asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The purpose of this study was to determine the clinical significance of changes in the plasma adiponectin concentration in patients with bronchial asthma and to test the association between the single nucleotide polymorphisms (SNPs) rs2241766 and rs1501299 in the ADIPOQ gene and bronchial asthma in the Chinese Li population.
|
26546898 |
2015 |
|
Human immunodeficiency virus (HIV) II infection category B1
|
|
0.010 |
GeneticVariation
|
BEFREE |
The presence of the ADIPOQ rs2241766 G allele (GG/GT genotype) was associated with a protective effect against dyslipidemia, primarily in HIV/HCV-coinfected patients with steatosis.
|
24528335 |
2014 |
|
Complications of Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study aims to examine the association of tumor necrosis factor-α (TNF-α) g.-308 G > A and adiponectin (ADIPOQ) g. + 45 T > G gene polymorphisms in type 2 diabetes (T2D) and its microvascular complications diabetic retinopathy (DR) and diabetic nephropathy (DN).
|
24655058 |
2014 |
|
Steatohepatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The presence of the ADIPOQ rs2241766 G allele (GG/GT genotype) was associated with a protective effect against dyslipidemia, primarily in HIV/HCV-coinfected patients with steatosis.
|
24528335 |
2014 |
|
Diabetic Retinopathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, the ADIPOQ g. + 45 T > G polymorphism shows significant association in T2D (p = 0.048) and DR (p = 0.001) but in DN patients, no association was observed.
|
24655058 |
2014 |
|
Dyslipidemias
|
|
0.010 |
GeneticVariation
|
BEFREE |
The presence of the ADIPOQ rs2241766 G allele (GG/GT genotype) was associated with a protective effect against dyslipidemia, primarily in HIV/HCV-coinfected patients with steatosis.
|
24528335 |
2014 |
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
The presence of the ADIPOQ rs2241766 G allele (GG/GT genotype) was associated with a protective effect against dyslipidemia, primarily in HIV/HCV-coinfected patients with steatosis.
|
24528335 |
2014 |
|
Acute Chest Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study suggests that only T45G single-nucleotide polymorphism in the adiponectin gene is associated with higher odds for ACS events and has an effect on serum adiponectin levels among Arab populations.
|
22887729 |
2013 |
|
Peripheral Arterial Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
We hypothesized that adiponectin gene SNP+45 (rs2241766) and SNP+276 (rs1501299) would be associated with atherosclerotic peripheral arterial disease (PAD).
|
23819115 |
2013 |
|
Metabolic Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Adiponectin gene polymorphisms (T45G and G276T), adiponectin levels and risk for metabolic diseases in an Arab population.
|
22155316 |
2012 |
|
Non-Small Cell Lung Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The TT genotype of rs2241766 was significantly associated with susceptibility to NSCLC</span> before and after adjustment for age, sex, body mass index, and smoking status.
|
21619462 |
2011 |
|
Hypoadiponectinemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The T45G polymorphism in the ADIPOQ gene and hypoadiponectinemia were associated with CAD in our T2D subjects of predominantly African background.
|
19960000 |
2010 |
|
Hyperandrogenism
|
|
0.010 |
GeneticVariation
|
BEFREE |
The risk of PCOS, hyperandrogenism in patients with PCOS and low serum adiponectin levels cannot be directly attributed to T45G adiponectin gene polymorphisms in exon 2, rather these polymorphisms may be associated with insulin resistance and hyperinsulinemia in PCOS.
|
20388053 |
2010 |
|
Conn Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic analysis of T45G and G276T adiponectin gene polymorphisms showed that, while the genotypes 45G/G+G/T seemed to have a protective role on the metabolic complications, the genotype 276T/T defined PA and EH patients with a worse metabolic profile.
|
19481913 |
2010 |
|
Hyperinsulinism
|
|
0.010 |
GeneticVariation
|
BEFREE |
The risk of PCOS, hyperandrogenism in patients with PCOS and low serum adiponectin levels cannot be directly attributed to T45G adiponectin gene polymorphisms in exon 2, rather these polymorphisms may be associated with insulin resistance and hyperinsulinemia in PCOS.
|
20388053 |
2010 |
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Based on the known function of rs2241766 and rs1501299, we categorized individuals by adiponectin signaling status and found that, when compared with high signalers, intermediate signalers had a 4.16-fold increase in breast cancer risk (95% CI, 0.49-35.19), and low signalers had a 6.56-fold increase in breast cancer risk (95% CI, 0.78-54.89; P(trend) = 0.001).
|
18451143 |
2008 |
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
Based on the known function of rs2241766 and rs1501299, we categorized individuals by adiponectin signaling status and found that, when compared with high signalers, intermediate signalers had a 4.16-fold increase in breast cancer risk (95% CI, 0.49-35.19), and low signalers had a 6.56-fold increase in breast cancer risk (95% CI, 0.78-54.89; P(trend) = 0.001).
|
18451143 |
2008 |