|
Aggressive Periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The data analysis revealed a significantly higher frequency distribution of the rs2241880 G (odds ratio [OR] = 1.88, p = 0.0073) and rs2241879 A (OR = 1.87, p = 0.0079) allele in the PPP group when compared with the control group.
|
21513755 |
2011 |
|
Carcinogenesis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest that ATG16L1 T300A polymorphism may be associated with gastric carcinogenesis.
|
26547861 |
2016 |
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Lung cancer cell lines stably transfected with ATG16L1: rs2241880 (T300A) were established.
|
28441070 |
2017 |
|
Cirrhosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The ATG16L1 gene variant rs2241880 (p.T300A) is associated with susceptibility to HCC in patients with cirrhosis.
|
31484215 |
2019 |
|
Colonic Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Using binary logistic regression analysis we confirmed the effect of rs2241880 genotype (GG) on ileal disease versus colonic disease (P = 0.03, OR 2.43, 95% CI 1.05-5.65).
|
18088053 |
2008 |
|
Colorectal Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
In this study, we aimed to determine if ATG16L1 +898A>G (Thr300Ala) polymorphism is associated with an increased risk of developing colorectal cancer (CRC) and to establish correlations between ATG16L1 genotypes and the major clinical and morphological parameters.
|
24715166 |
2014 |
|
Colorectal Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The CD-risk allele, Thr300Ala, in ATG16L1 is associated with improved overall survival in human CRC, generating a rationale to genotype ATG16L1 Thr300Ala in patients with CRC.
|
25645662 |
2016 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Human macrophages with the Crohn's disease-associated Atg16l1 variant T300A exhibited more production of IFN-β and IL-1β.
|
29358708 |
2018 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The association of ATG16L1 T300A with CD was confirmed [P = 0.004, odds ratio (OR) = 1.69, 95% CI: 1.19-2.41], and both IL23R variants were found to represent significant risk for the disease (P = 0.008, OR = 2.05, 95% CI: 1.20-3.50 for rs1004819 AA; P < 0.001, OR = 2.97, 95% CI: 1.65-5.33 for rs2201841 CC).
|
20066736 |
2010 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The CD-risk allele, Thr300Ala, in ATG16L1 is associated with improved overall survival in human CRC, generating a rationale to genotype ATG16L1 Thr300Ala in patients with CRC.
|
25645662 |
2016 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In conclusion, our results confirm the ATG16L1 rs2241880 and IRGM rs13361189 and rs4958847 polymorphisms as important markers for CD susceptibility and indicate that these variants are also associated with UC.
|
19491842 |
2009 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Unconventional autophagy mediated by the WD40 domain of ATG16L1 is derailed by the T300A Crohn disease risk polymorphism.
|
27541200 |
2016 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We replicated the previously reported associations between CD and rs11209026 and rs2241880, confirming that IL23R and ATG16L1 are susceptibility loci for CD in the New Zealand population.
|
17894849 |
2007 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
For ATG16L1, the rs2241880 SNP was associated with CD susceptibility (OR 1.36, CI 1.12-1.66, P= 0.0017).
|
18047540 |
2008 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Systematic association mapping identifies NELL1 as a novel IBD disease gene.
|
17684544 |
2007 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
ATG16L1 has been particularly well studied in knockout and hypomorph settings as well as models recapitulating the Crohn disease-associated T300A polymorphism.
|
31451676 |
2019 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Individuals who harbor a common coding polymorphism (Thr300Ala) within a structurally unclassified region of ATG16L1 are at increased risk for the development of Crohn disease.
|
25136803 |
2014 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
|
22412388 |
2012 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
As no epistatic interaction with three common NOD2/CARD15 mutations was observed, the p.Thr300Ala substitution is an independent risk factor for paediatric CD and supports the role for autophagy in disease pathogenesis.
|
19659808 |
2009 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population.
|
18162085 |
2008 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
IL23R R381Q and ATG16L1 T300A are strongly associated with Crohn's disease in a study of New Zealand Caucasians with inflammatory bowel disease.
|
17894849 |
2007 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
DC of pediatric patients with CD carrying the T300A allele showed a marked impairment of antigen uptake and processing and defective interactions between DC and intestinal epithelium.
|
24022642 |
2013 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - Arg381Gln (rs11209026) and ATG16L1 - Thr300Ala (rs2241880).
|
20082483 |
2010 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
With respect to ATG16L1, the G allele of SNP rs2241880 has been shown in multiple association studies to confer strong risk for CD, although its association with UC remains more debatable.
|
18366306 |
2008 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We found a statistically significant interaction with respect to Crohn disease risk between rs2241880 and the established CARD15 susceptibility variants (P = 0.039).
|
17200669 |
2007 |