|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We replicated the previously reported associations between CD and rs11209026 and rs2241880, confirming that IL23R and ATG16L1 are susceptibility loci for CD in the New Zealand population.
|
17894849 |
2007 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Systematic association mapping identifies NELL1 as a novel IBD disease gene.
|
17684544 |
2007 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
IL23R R381Q and ATG16L1 T300A are strongly associated with Crohn's disease in a study of New Zealand Caucasians with inflammatory bowel disease.
|
17894849 |
2007 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We found a statistically significant interaction with respect to Crohn disease risk between rs2241880 and the established CARD15 susceptibility variants (P = 0.039).
|
17200669 |
2007 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.
|
17435756 |
2007 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The association appeared to be confined to the nsSNP rs2,241,880 and was confirmed in 2 German independent case-control collections (combined P = 4.0 x 10(-8), odds ratio [OR] 1.45; 95% confidence interval [CI]: 1.21-1.74), a CD transmission disequilibrium test (TDT) collection, and an independent UK cohort.
|
17455206 |
2007 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The association of T300A was replicated in the independent sample of 727 Crohn's disease cases (P = .001), and was strongly associated in the extended analysis of 1236 Crohn's cases (P = 2.4 x 10(-6)).
|
17484864 |
2007 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.
|
17435756 |
2007 |
|
Inflammatory Bowel Disease 10
|
|
0.700 |
GeneticVariation
|
UNIPROT |
A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5.
|
17484864 |
2007 |
|
Inflammatory Bowel Disease 10
|
|
0.700 |
GeneticVariation
|
UNIPROT |
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1.
|
17200669 |
2007 |
|
Inflammatory Bowel Disease 10
|
|
0.700 |
GeneticVariation
|
UNIPROT |
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.
|
17435756 |
2007 |
|
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Together with the lack of association between rs2241880 and ulcerative colitis (P > 0.4), these data suggest that the underlying biological process may be specific to Crohn disease.
|
17200669 |
2007 |
|
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Allele frequencies of rs11209026 and rs2241880 were determined in 496 CD patients, 466 ulcerative colitis (UC) patients, and 591 controls.
|
17894849 |
2007 |
|
Inflammatory Bowel Diseases
|
|
0.070 |
GeneticVariation
|
BEFREE |
IL23R R381Q and ATG16L1 T300A are strongly associated with Crohn's disease in a study of New Zealand Caucasians with inflammatory bowel disease.
|
17894849 |
2007 |
|
Inflammatory Bowel Diseases
|
|
0.070 |
GeneticVariation
|
BEFREE |
Distribution of the relevant alleles was compared between controls and IBD patients. rs11209026 and rs2241880 genotype distributions were examined both within IBD clinical subphenotypes and CARD15 genotypes.
|
17894849 |
2007 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
For ATG16L1, the rs2241880 SNP was associated with CD susceptibility (OR 1.36, CI 1.12-1.66, P= 0.0017).
|
18047540 |
2008 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population.
|
18162085 |
2008 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
With respect to ATG16L1, the G allele of SNP rs2241880 has been shown in multiple association studies to confer strong risk for CD, although its association with UC remains more debatable.
|
18366306 |
2008 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genotyping for CARD15 (R702W, G908R, 3020insC), IL23R (rs1004819, rs7517847, rs11209026, rs10889677, rs1495965), and ATG16L1 (rs2241880) was performed in 187 children and adults with CD and 255 healthy ethnically matched controls.
|
18200510 |
2008 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We confirm the strong association between T300A and CD, specifically ileal subphenotype, and also report the first strong association of this variant with UC.
|
18671817 |
2008 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs2241880A/G variant of the ATG16L1 gene has been associated with susceptibility to ileal Crohn's disease (CD) in adults.
|
18088053 |
2008 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We confirmed a strong association between three NOD2/CARD15 gene variants (Pro268Ser, OR = 2.52, 95% CI = 1.34-4.75); (Arg702Trp, OR = 6.65, 95% CI = 1.99-22.17); (1007fs, OR = 9.59, 95% CI = 3.94-23.29), and a weak association between both the protective OCTN1/OCTN2 CC haplotype (OR = 0.28, 95% CI = 0.08-0.94), and a variant of ATG16L1 gene (Thr300Ala, OR = 0.468, 95% CI = 0.24-0.90) with Crohn's disease.
|
18715515 |
2008 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population.
|
18162085 |
2008 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
|
Crohn Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
A single common coding variant in the autophagy protein ATG16L1 predisposes individuals to the development of Crohn's disease: while ATG16L1 encoding threonine at amino acid position 300 (ATG16L1*300T) confers protection, ATG16L1 encoding for alanine instead of threonine (ATG16L1*300A, also known as T300A) mediates risk towards the development of Crohn's disease.
|
18852889 |
2008 |