rs2259816, HNF1A

N. diseases: 8
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.820 GeneticVariation GWASDB Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. 21347282 2011
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.820 GeneticVariation BEFREE Five single-nucleotide polymorphisms, rs4977574 (CDKN2A/2B), rs12526453 (PHACTR1), rs646776 (CELSR2-PSRC1-SORT1), rs2259816 (HNF1A), and rs11206510 (PCSK9) showed directionally consistent associations with CHD in the 3 studies, with combined odds ratios (ORs) ranging from 1.17 to 1.25 (p = 0.03 to 0.0002). 22152955 2011
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.820 GeneticVariation BEFREE In the LURIC Study cohort the A-allele of rs2259816 is associated with decreased CRP but not with coronary artery disease. 21062467 2010
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.820 GeneticVariation GWASCAT New susceptibility locus for coronary artery disease on chromosome 3q22.3. 19198612 2009
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.820 GeneticVariation GWASDB New susceptibility locus for coronary artery disease on chromosome 3q22.3. 19198612 2009
C-reactive protein measurement
CUI: C0201657
Disease: C-reactive protein measurement
0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
C-reactive protein measurement
CUI: C0201657
Disease: C-reactive protein measurement
0.800 GeneticVariation GWASDB New variants including ARG1 polymorphisms associated with C-reactive protein levels identified by genome-wide association and pathway analysis. 24763700 2014
C-reactive protein measurement
CUI: C0201657
Disease: C-reactive protein measurement
0.800 GeneticVariation GWASDB Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore? 23844046 2013
C-reactive protein measurement
CUI: C0201657
Disease: C-reactive protein measurement
0.800 GeneticVariation GWASCAT Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women. 22939635 2012
C-reactive protein measurement
CUI: C0201657
Disease: C-reactive protein measurement
0.800 GeneticVariation GWASDB Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women. 22939635 2012
Pseudocholinesterase Measurement
CUI: C1168443
Disease: Pseudocholinesterase Measurement
0.700 GeneticVariation GWASDB Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits. 21943158 2011
Acute Chest Syndrome
CUI: C0742343
Disease: Acute Chest Syndrome
0.010 GeneticVariation BEFREE The alleles of rs12190287 (MRAS), rs121902287 (TCF21) and rs2259816 (HNF1a) were associated with a higher risk of ACS. 27888760 2017
Hypertriglyceridemia
CUI: C0020557
Disease: Hypertriglyceridemia
0.010 GeneticVariation BEFREE Hypertriglyceridemia was linked to the rs2393791_T (1.14 (1.02-1.27); P = 0.018), rs7310409_G (1.12 (1.01-1.25); P = 0.031), rs1169310_G (1.15 (1.04-1.28); P = 0.010), and rs1169313_CT+TT (1.24 (1.06-1.45); P = 0.008) and high low density lipoprotein-cholesterol levels were associated with rs2259820_T (1.23 (1.07-1.41); P = 0.004), rs2464196_T (1.22 (1.06-1.39); P = 0.004), and rs2259816_T (1.18 (1.02-1.36); P = 0.023). 25057215 2014
Diabetic Nephropathy
CUI: C0011881
Disease: Diabetic Nephropathy
0.010 GeneticVariation BEFREE Despite no significance in genetic analysis of diabetic subjects, SNP rs2259816 in the HNF1A gene tended to associate with diabetic nephropathy in type 1 diabetic patients. 22849862 2012
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.010 GeneticVariation BEFREE In the LURIC Study cohort the A-allele of rs2259816 is associated with decreased CRP but not with coronary artery disease. 21062467 2010
Coronary Arteriosclerosis
CUI: C0010054
Disease: Coronary Arteriosclerosis
0.010 GeneticVariation BEFREE In the LURIC Study cohort the A-allele of rs2259816 is associated with decreased CRP but not with coronary artery disease. 21062467 2010