Source: ALL
Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Carcinoma of bladder
CUI: C0699885
Disease: Carcinoma of bladder
0.860 GeneticVariation BEFREE Based on the statistical evidence, we can draw a conclusion that the rs2294008 polymorphism of PSCA gene is likely to play a role in cancer carcinogenesis, especially in gastric cancer and bladder cancer. 26308216 2016
Carcinoma of bladder
CUI: C0699885
Disease: Carcinoma of bladder
0.860 GeneticVariation BEFREE Overall, seven of the 14 variants were significantly associated with bladder cancer risk (p = 9.763 × 10(-3) for rs9642880 at 8q24.21, p = 3.004 × 10(-3) for rs2294008 at 8q24.3, p = 0.012 for rs798766 at 4p16.3, p = 0.034 for rs1495741 at 8p22, p = 2.306 × 10(-4) for GSTM1, p = 8.507 × 10(-8) for rs17674580 at 18q12.3, p = 7.179 × 10(-4) for rs10936599 at 3q26.2) and the odds ratios (ORs) ranged from 1.13 to 1.65. 24740636 2014
Carcinoma of bladder
CUI: C0699885
Disease: Carcinoma of bladder
0.860 GeneticVariation BEFREE The study suggests that anti-PSCA immunotherapy might be beneficial for bladder cancer patients with high tumor PSCA expression, which is statistically significantly associated with the presence of CT and TT genotypes of a common genetic variant, rs2294008. 23266392 2013
Carcinoma of bladder
CUI: C0699885
Disease: Carcinoma of bladder
0.860 GeneticVariation BEFREE In conclusion, a joint effect of two PSCA SNPs, rs2294008 and rs2978974, suggests that both variants may be important for bladder cancer susceptibility, possibly through different mechanisms that influence the control of mRNA expression and interaction with regulatory factors. 22416122 2012
Carcinoma of bladder
CUI: C0699885
Disease: Carcinoma of bladder
0.860 GeneticVariation BEFREE These results indicated that the rs2294008 polymorphism of PSCA gene may play a role in bladder cancer carcinogenesis and it could be served as a biomarker for genetic susceptibility to bladder cancer in Chinese populations. 20083643 2010
Carcinoma of bladder
CUI: C0699885
Disease: Carcinoma of bladder
0.860 GeneticVariation GWASDB A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. 20972438 2010
Carcinoma of bladder
CUI: C0699885
Disease: Carcinoma of bladder
0.860 GeneticVariation GWASCAT A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. 20972438 2010
Carcinoma of bladder
CUI: C0699885
Disease: Carcinoma of bladder
0.860 GeneticVariation GWASCAT Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer. 19648920 2009
Carcinoma of bladder
CUI: C0699885
Disease: Carcinoma of bladder
0.860 GeneticVariation GWASDB Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer. 19648920 2009
Carcinoma of bladder
CUI: C0699885
Disease: Carcinoma of bladder
0.860 GeneticVariation BEFREE Our data identify rs2294008 as a new bladder cancer susceptibility locus. 19648920 2009
Duodenal Ulcer
CUI: C0013295
Disease: Duodenal Ulcer
0.830 GeneticVariation BEFREE Frequency of PSCA rs2294008 C/C genotype in duodenal ulcer was 36.1%, which was significantly higher than those with gastric cancer (12.4%), gastric ulcer (19.0%), gastritis (10.7%), and H. pylori-negatives (19.5%) (p < .001). 25582162 2015
Duodenal Ulcer
CUI: C0013295
Disease: Duodenal Ulcer
0.830 GeneticVariation BEFREE Association of PSCA rs2294008 gene variants with poor prognosis and increased susceptibility to gastric cancer and decreased risk of duodenal ulcer disease. 25721731 2015
Duodenal Ulcer
CUI: C0013295
Disease: Duodenal Ulcer
0.830 GeneticVariation BEFREE The T allele of rs2294008 encodes a translation initiation codon upstream of the reported site and changes protein localization from the cytoplasm to the cell surface. rs505922 at ABO was also associated with duodenal ulcer in a recessive model (OR = 1.32; P = 1.15 × 10(-10)). 22387998 2012
Duodenal Ulcer
CUI: C0013295
Disease: Duodenal Ulcer
0.830 GeneticVariation GWASCAT A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population. 22387998 2012
Duodenal Ulcer
CUI: C0013295
Disease: Duodenal Ulcer
0.830 GeneticVariation GWASDB A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population. 22387998 2012
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.800 GeneticVariation BEFREE In conclusion, the results indicated that the PSCA rs2294008 T and rs2976392 A alleles were low-penetrate risk factors for GCa in this study population. 26848528 2017
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.800 GeneticVariation GWASCAT Identification of new susceptibility loci for gastric non-cardia adenocarcinoma: pooled results from two Chinese genome-wide association studies. 26701879 2017
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.800 GeneticVariation BEFREE Genetic Variation of BCL2 (rs2279115), NEIL2 (rs804270), LTA (rs909253), PSCA (rs2294008) and PLCE1 (rs3765524, rs10509670) Genes and Their Correlation to Gastric Cancer Risk Based on Universal Tagged Arrays and Fe3O4 Magnetic Nanoparticles. 26554163 2016
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.800 GeneticVariation BEFREE Based on the statistical evidence, we can draw a conclusion that the rs2294008 polymorphism of PSCA gene is likely to play a role in cancer carcinogenesis, especially in gastric cancer and bladder cancer. 26308216 2016
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.800 GeneticVariation BEFREE Specifically, a significant increased stomach cancer risk was associated with PSCA rs2294008 (CT vs. CC: adjusted OR = 1.37, 95% CI = 1.07-1.74, and CT/TT vs.CC: adjusted OR = 1.30, 95% CI = 1.03-1.63), PSCA rs2976392 (AG vs. GG: adjusted OR = 1.30, 95% CI = 1.02-1.65, and AG/AA vs. GG: adjusted OR = 1.26, 95% CI = 1.00-1.59), or PLCE1 rs2274223 (AG vs. AA: adjusted OR = 1.48, 95% CI = 1.15-1.90, and AG/GG vs. AA: adjusted OR = 1.45, 95% CI = 1.14-1.84), respectively. 25658482 2016
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.800 GeneticVariation BEFREE The PSCA rs2294008 C>T polymorphism may be acting through induction of gastric mucosal atrophy, finally leading to development of gastric ulcer and gastric cancer in PSCA rs2294008 T allele carriers, but not duodenal ulcer. 25582162 2015
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.800 GeneticVariation GWASCAT Loss-of-function variants in ATM confer risk of gastric cancer. 26098866 2015
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.800 GeneticVariation BEFREE Association of PSCA rs2294008 gene variants with poor prognosis and increased susceptibility to gastric cancer and decreased risk of duodenal ulcer disease. 25721731 2015
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.800 GeneticVariation BEFREE The variant C allele of the reference SNP rs2294008 in the PSCA gene was associated with a significantly reduced risk of GC (per allele-adjusted odds ratio [aOR], 0.51; 95% confidence interval [CI], 0.33-0.77; P = .002). 24962126 2014
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.800 GeneticVariation BEFREE Our findings demonstrated that rs2294008 and rs2976392 polymorphism of PSCA is a risk-conferring factor associated with increased GC susceptibility, especially in East Asians. 24146278 2014