|
Alopecia Areata
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci.
|
25608926 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
We performed case-control and family-based association studies to assess if the CTLA4 A49G and intron 1 C/T polymorphisms were associated with development of early onset type 1 diabetes in the Northern Ireland population.
|
11477480 |
2001 |
|
Autoimmune Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Because the functional single-nucleotide polymorphism (SNP) rs231775 of the CTLA-4 gene is associated with autoimmune diseases and because of the critical role of the immune reaction in sepsis, we intended to examine the effect of this polymorphism on survival in patients with sepsis.
|
30310101 |
2018 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The CTLA-4 49 A/G polymorphism was detected by the PCR-restriction fragment-length polymorphism (RFLP) method in 97 type 1 diabetic subjects and 20 patients with Graves' disease, a cohort which included 4 patients who also had type 1 diabetes.
|
12610047 |
2003 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of our study was to investigate whether the CTLA4 polymorphisms, including -318C/T (rs5742909), +49A/G (rs231775), and CT60 (rs3087243), were associated with GD and HD in Han Chinese adults and children.
|
27111218 |
2016 |
|
Autoimmune Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The cytotoxic T lymphocyte-associated antigen (CTLA)-4 molecule plays an important role in immune regulation by downregulating T-cell activation, and the CTLA-4 49A/G polymorphism in the exon 1 has been shown to be associated with a number of autoimmune diseases.
|
16045690 |
2005 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
We report the association of CTLA-4 A49G variation (cytotoxic T-lymphocyte associated-4) to TID among Filipinos, consistent with some but not all previous reports in other ethnic groups.
|
12185534 |
2002 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data indicate that CTLA-4 exon 1 position 49 A/G dimorphism was significantly associated with predisposition to IDDM in our Central Poland population, particularly in patients lacking the strongly predisposing DRB1 alleles.
|
9690057 |
1998 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Evaluated was the role of the CTLA4 exon 1 A49G polymorphism and its role as a risk factor for T1D in our population.
|
15301861 |
2004 |
|
Autoimmune Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Its nonsynonymous polymorphism +49G > A (dbSNP: rs231775) has been linked to an elevated risk of T-cell-mediated autoimmune diseases, infectious diseases, and even carcinomas.
|
19778566 |
2010 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of PTPN22 C1858T and CTLA-4 A49G polymorphisms with Type 1 Diabetes in Croatians.
|
19815302 |
2009 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between GD and the G allele of the Thr17Ala polymorphism within the CTLA-4 gene ( CTLA4A/G ) was observed using unaffected sib controls ( P = 0.005).
|
10369864 |
1999 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
The 49A/G dimorphism in exon 1 and the (AT)n in the 3' untranslated region of the CTLA-4 gene were significantly associated with type 1 diabetes.
|
11685455 |
2001 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
The influence of polymorphisms of INS(-23Hph1), CTLA-4(T17A), and PTPN22(R620W) on development of persistent islet autoimmunity and progression to type 1 diabetes was evaluated by parametric models and by survival analyses.
|
19188433 |
2009 |
|
Autoimmune Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our present study indicates that CTLA-4 +49 G/A (rs231775) is associated with the susceptibility of autoimmune disease.
|
28384040 |
2017 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Group-level data suggested significant associations with GD and HT for both A49G [odds ratios 1.49 (P = 6 x 10(-14)) and 1.29 (P = 0.001) per G allele, respectively] and CT60 [1.45 (P = 2 x 10(-9)) and 1.64 (P = 0.003) per G allele, respectively].
|
17504905 |
2007 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
(i) Allele G and G/G genotype confer genetic susceptibility to GD; (ii) CTLA-4 A49G polymorphism is not associated with the development of GO; (iii) different non-genetic factors may contribute to GO in different populations.
|
12534352 |
2003 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The CTLA-4 SNPs (-318C/T, 49A/G, and CT60A/G) were in the same haplotype block, and the CGG haplotype was associated with GD (P = 0.0071) but not GO.
|
18296657 |
2008 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis demonstrated that the G allele of rs231775 of CTLA-4 is a risk factor associated with increased T1D susceptibility.
|
23261825 |
2013 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Some gene polymorphisms, such as <i>CTLA4</i> rs231775, human leukocyte antigen polymorphisms (<i>DRB1*03, DQA1*05</i>, and <i>DQB1*02</i>) might be associated with the high recurrence risk in GD patients.
|
29085334 |
2017 |
|
Autoimmune Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interestingly, we have recently shown that an SNP in the CTLA-4 coding region (49A > G) is also associated with susceptibility to human cancer, but the risk allele for susceptibility to cancer (allele A) is the opposite of that found for susceptibility to autoimmune disease (allele G), which has been confirmed by a meta-analysis of reported studies.
|
19638588 |
2009 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The G allele of A49G, the G allele of CT60, and the 280 allele of (AT)(n)-3'UTR microsatellite were significantly increased in patients with GD with thyroid-associated ophthalmopathy (TAO) compared to controls (p = 0.04, p = 0.03, and p = 0.02, respectively), however, we did not find any significant difference between TAO and non-TAO patients.
|
15785242 |
2005 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
The CTLA-4 49 A/G polymorphism was detected by the PCR-restriction fragment-length polymorphism (RFLP) method in 97 type 1 diabetic subjects and 20 patients with Graves' disease, a cohort which included 4 patients who also had type 1 diabetes.
|
12610047 |
2003 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
CTLA4 rs231775 and TNF-αrs1800629 were not associated with T1D onset in the Brazilian population.
|
26782543 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
In a combined analysis, the summary per-allele odds ratio (OR) for T1D of the G49A and C60T polymorphism was 1.42 [95% confidence interval (CI): 1.31-1.53, P<10(-5)] and 1.23 (95% CI: 1.18-1.29, P<10(-5)), respectively.
|
24465825 |
2014 |