|
Acquired haemophilia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Increased frequency of the CTLA-4 49 A/G polymorphism in patients with acquired haemophilia A compared to healthy controls.
|
18081831 |
2008 |
|
Acute anterior uveitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
There was no significant association between PTPN22 620W, CTLA-4 -318C/T, or CTLA-4 49A/G and AAU.
|
19180256 |
2009 |
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Eighty-eight children with acute leukemia and their donors were genotyped of CTLA-4 gene for rs231775.
|
30465728 |
2019 |
|
Acute lymphocytic leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
153 donors and 153 children with acute lymphoblastic leukemia, acute myeloid leukemia or juvenile myelomonocytic leukemia who had undergone allogeneic HSCT were genotyped of CTLA-4 gene for rs3087243 (CT60G>A), rs231775 (+ 49 A>G) and rs4553808 using TaqMan real-time polymerase chain reaction.
|
29335768 |
2018 |
|
Addison's disease due to autoimmunity
|
|
0.010 |
GeneticVariation
|
BEFREE |
The G-allele of SNP rs231775 in CTLA-4 is associated with AAD in Norwegian patients (odds ratio (OR)=1.35 (confidence interval (CI) 1.10-1.66), P=0.004), but not in UK patients.
|
26204230 |
2015 |
|
Adenocarcinoma, Clear Cell
|
|
0.010 |
GeneticVariation
|
BEFREE |
The strongest associations were found for endometrioid carcinoma and IL2RA SNPs rs11256497 [HR, 1.42; 95% confidence interval (CI), 1.22-1.64; P = 5.7 × 10(-6)], rs791587 (HR, 1.36; 95% CI, 1.17-1.57; P = 6.2 × 10(-5)), rs2476491 (HR, = 1.40; 95% CI, 1.19-1.64; P = 5.6 × 10(-5)), and rs10795763 (HR, 1.35; 95% CI, 1.17-1.57; P = 7.9 × 10(-5)), and for clear cell carcinoma and CTLA4 SNP rs231775 (HR, 0.67; 95% CI, 0.54-0.82; P = 9.3 × 10(-5)) after adjustment for age, study site, population stratification, stage, grade, and oral contraceptive use.
|
24764580 |
2014 |
|
Adrenoleukodystrophy
|
|
0.010 |
GeneticVariation
|
BEFREE |
To determine whether the functional A49G polymorphism of cytotoxic T-lymphocyte antigen-4 (CTLA-4), a T-cell surface molecule that modulates T-lymphocyte activation and influences the risk of developing alcohol-induced autoantibodies, plays a role in susceptibility to alcoholic liver disease (ALD) and influences disease severity in Italian alcohol abusers.
|
15208156 |
2004 |
|
Alcoholic Liver Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Cytotoxic T-lymphocyte antigen-4 A49G polymorphism is associated with susceptibility to and severity of alcoholic liver disease in Italian patients.
|
15208156 |
2004 |
|
Alopecia Areata
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci.
|
25608926 |
2015 |
|
AMELOGENESIS IMPERFECTA, HYPOPLASTIC/HYPOMATURATION, X-LINKED 1
|
|
0.010 |
GeneticVariation
|
BEFREE |
CTLA-4 exon-1 +49A > G (rs231775) polymorphism has been reported to influence the risk for primary biliary cirrhosis (PBC) as well as type I autoimmune hepatitis (AIH-1) in many studies; however, the results still remain controversial and ambiguous.
|
25942345 |
2015 |
|
Ankylosing spondylitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The genotype analysis showed that AA genotype of + 49A/G polymorphism could increase the risk for AS (OR=2.357, 95% CI=1.127-4.930).
|
26261646 |
2015 |
|
Aplastic Anemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
The GG genotype of SNP rs231775 in CTLA-4 gene might be associated with AA risk in the Chinese population.
|
27036622 |
2016 |
|
Aplastic Anemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study indicates that the polymorphisms -318C > T and 49A > G of CTLA4 do not affect the risk of developing AA and do not influence the response to immunosuppression.
|
15812539 |
2005 |
|
Asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
To investigate associations between total serum immunoglobulin E (IgE) levels and single nucleotide polymorphisms (SNPs) from eight candidate genes (IL-4 rs2243250, IL-4Rα rs1805010, IL-13 rs20541, IL-13Rα1 rs2495636, CD14 rs2569190, tumor necrosis factor-alpha (TNF-α) rs1800629, cytotoxic T lymphocyte-associated antigen (CTLA4) rs231775, FCER1B rs1441585) in children with asthma and to evaluate gene-gene interactions.
|
22376040 |
2012 |
|
Autoimmune Chronic Hepatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
CTLA-4 exon-1 +49A > G (rs231775) polymorphism has been reported to influence the risk for primary biliary cirrhosis (PBC) as well as type I autoimmune hepatitis (AIH-1) in many studies; however, the results still remain controversial and ambiguous.
|
25942345 |
2015 |
|
Autoimmune Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Because the functional single-nucleotide polymorphism (SNP) rs231775 of the CTLA-4 gene is associated with autoimmune diseases and because of the critical role of the immune reaction in sepsis, we intended to examine the effect of this polymorphism on survival in patients with sepsis.
|
30310101 |
2018 |
|
Autoimmune Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The cytotoxic T lymphocyte-associated antigen (CTLA)-4 molecule plays an important role in immune regulation by downregulating T-cell activation, and the CTLA-4 49A/G polymorphism in the exon 1 has been shown to be associated with a number of autoimmune diseases.
|
16045690 |
2005 |
|
Autoimmune Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Its nonsynonymous polymorphism +49G > A (dbSNP: rs231775) has been linked to an elevated risk of T-cell-mediated autoimmune diseases, infectious diseases, and even carcinomas.
|
19778566 |
2010 |
|
Autoimmune Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our present study indicates that CTLA-4 +49 G/A (rs231775) is associated with the susceptibility of autoimmune disease.
|
28384040 |
2017 |
|
Autoimmune Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interestingly, we have recently shown that an SNP in the CTLA-4 coding region (49A > G) is also associated with susceptibility to human cancer, but the risk allele for susceptibility to cancer (allele A) is the opposite of that found for susceptibility to autoimmune disease (allele G), which has been confirmed by a meta-analysis of reported studies.
|
19638588 |
2009 |
|
Autoimmune Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
It has been found that CTLA4 +49A>G (rs231775), +6230G>A (rs3087243), and 11430G>A (rs11571319) polymorphisms are associated with susceptibility to many autoimmune diseases, and can down-regulate the inhibition of cellular immune response of CTLA4.
|
22811616 |
2012 |
|
Autoimmune Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results may therefore lend support to the hypothesis that humoral autoimmunity is correlated with 49A/G and CT60 polymorphisms of the CTLA-4 gene.
|
19559744 |
2009 |
|
Autoimmune Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our observations of a higher frequency of the CTLA-4 + 49 A/G SNP in AH patients are in concordance with findings in other autoimmune disorders.
|
18081831 |
2008 |
|
Autoimmune Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
While there was no association with vitiligo overall, the meta-analysis showed significant association of SNP rs231775 in that subgroup of vitiligo patients who also had other concomitant autoimmune diseases.
|
19175525 |
2009 |
|
Autoimmune Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Gene polymorphisms involving CTLA-4 promoter (-318 C/T), exon 1 (49 A/G), and exon 4 (microsatellite (AT)n) have been linked to Hashimoto's thyroiditis (HT) and other autoimmune diseases.
|
12225635 |
2002 |