|
Alcoholic Intoxication, Chronic
|
|
0.050 |
GeneticVariation
|
BEFREE |
Although C-allele carriers have been shown to have an increased risk for alcohol dependence, in our dependent sample, greater stimulation was found among T-allele homozygotes, suggesting that the influence of SR on developing and maintaining dependence differs based on rs279858 genotype.This study demonstrates an indirect effect of rs279858 genotype on drinking through SR.
|
27117237 |
2016 |
|
Alcoholic Intoxication, Chronic
|
|
0.050 |
GeneticVariation
|
BEFREE |
The association of rs279858 with alcohol dependence yielded nominal significance level.
|
26116794 |
2015 |
|
Alcoholic Intoxication, Chronic
|
|
0.050 |
GeneticVariation
|
BEFREE |
Greater stimulatory and euphoric effects of alcohol in carriers of the rs279858 C allele may, in part, explain the previously reported association of this allele with AD.
|
24166645 |
2014 |
|
Alcoholic Intoxication, Chronic
|
|
0.050 |
GeneticVariation
|
BEFREE |
We used linear mixed models to examine the effects of dutasteride and alcohol on BAES and SS responses and the interaction of dutasteride with the GABRA2 alcohol dependence-associated polymorphism rs279858.
|
24557088 |
2014 |
|
Alcoholic Intoxication, Chronic
|
|
0.050 |
GeneticVariation
|
BEFREE |
In a sample of 173 families (449 subjects), 129 of whom had at least one member diagnosed with alcohol dependence or abuse, carriers for the G allele in two single-nucleotide polymorphisms (SNPs) and haplotypes were more likely to have alcohol dependence symptoms (rs279858, P=0.01; rs279826, P=0.05; haplotype, P=0.02) and higher NEO Personality Inventory-Revised (NEO-PI-R) Impulsiveness scores (rs279858, P=0.016; rs279826, P=0.012; haplotype, P=0.032) with a stronger effect in women (rs279858, P=0.011; rs279826, P=0.002; haplotype, P=0.006), all P-values are corrected for family history and age.
|
21483437 |
2012 |
|
Heroin Dependence
|
|
0.010 |
GeneticVariation
|
BEFREE |
The role of the reward network connections that mediates the effects of rs279858 on cognition would be disrupted by heroin addiction.
|
30061709 |
2018 |
|
Alcohol Use Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
For the BAES stimulation subscale scores, adjusting for age, baseline scores, and time effects, individuals with 2 copies of the GABRA2 rs279858 C "risk" allele for AUD exhibited the greatest stimulant responses to high-dose alcohol compared to the other risk allele counts (dose-by-allele count interaction effect, p = 0.001, post hoc contrast for C-allele, p = 0.012).
|
29131352 |
2017 |
|
Alcohol or Other Drugs use
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphisms across serotonergic (SLC6A4, 5-HTTLPR), dopaminergic (DRD4, u-VNTR), noradrenergic (SLC6A2, rs36021), and GABAergic (GABRA2, rs279858; GABRA6, rs3811995) genes were examined given prior support for associations with temperament, externalizing behavior, and substance use problems.
|
26845260 |
2016 |
|
Abnormal behavior
|
|
0.010 |
GeneticVariation
|
BEFREE |
We had several objectives: (a) to determine whether GABRA2 (rs279827, rs279826, rs279858) moderates the relationship between a component of parental monitoring, parental knowledge, and externalizing trajectories; (b) to test the form of this interaction to assess whether GABRA2 variants reflect risk (diathesis-stress) or susceptibility (differential susceptibility) factors; and (c) to clarify GABRA2 associations on the development of problem behavior.
|
25797587 |
2016 |
|
Impulsive character (finding)
|
|
0.010 |
GeneticVariation
|
BEFREE |
In a sample of 173 families (449 subjects), 129 of whom had at least one member diagnosed with alcohol dependence or abuse, carriers for the G allele in two single-nucleotide polymorphisms (SNPs) and haplotypes were more likely to have alcohol dependence symptoms (rs279858, P=0.01; rs279826, P=0.05; haplotype, P=0.02) and higher NEO Personality Inventory-Revised (NEO-PI-R) Impulsiveness scores (rs279858, P=0.016; rs279826, P=0.012; haplotype, P=0.032) with a stronger effect in women (rs279858, P=0.011; rs279826, P=0.002; haplotype, P=0.006), all P-values are corrected for family history and age.
|
21483437 |
2012 |
|
Drug abuse
|
|
0.010 |
GeneticVariation
|
BEFREE |
In a sample of 173 families (449 subjects), 129 of whom had at least one member diagnosed with alcohol dependence or abuse, carriers for the G allele in two single-nucleotide polymorphisms (SNPs) and haplotypes were more likely to have alcohol dependence symptoms (rs279858, P=0.01; rs279826, P=0.05; haplotype, P=0.02) and higher NEO Personality Inventory-Revised (NEO-PI-R) Impulsiveness scores (rs279858, P=0.016; rs279826, P=0.012; haplotype, P=0.032) with a stronger effect in women (rs279858, P=0.011; rs279826, P=0.002; haplotype, P=0.006), all P-values are corrected for family history and age.
|
21483437 |
2012 |
|
Drug Dependence
|
|
0.010 |
GeneticVariation
|
BEFREE |
These included a synonymous polymorphism in GABRA2 (rs279858), lying in a highly conserved region, which has been shown previously to be associated with alcohol and drug dependence.
|
18482426 |
2008 |