|
Malignant Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
rs231775, rs4553808 and rs5742909 but not rs3087243 and rs733618 were significantly related to cancer risk.
|
29794444 |
2018 |
|
Autoimmune thyroid disease (AITD)
|
|
0.030 |
GeneticVariation
|
BEFREE |
Furthermore, a joint analysis, with the INS and CTLA4 SNPs, revealed that CTLA4 rs3087243, ERBB3 rs2292399, and CLEC16A rs2903692, but not INS rs689, were significant risk factors for the cooccurrence of AITD in Japanese T1D.
|
18940880 |
2009 |
|
Malignant Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
We investigated the association of five CTLA4 single-nucleotide polymorphisms (SNPs) (rs733618 C/T, rs4553808 A/G, rs5742909 C/T, rs231775 A/G, and rs3087243 G/A) with de novo malignancy in 1463 Chinese renal transplantation (RT) recipients who underwent a 192-month follow-up.
|
25667935 |
2015 |
|
Malignant Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
Overall, no significant association was found between +49A/G (rs231775), -318C/T (rs5742909), and +6230A/G (rs3087243) CTLA-4 gene polymorphisms and lymphoid malignancies.
|
27498821 |
2016 |
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
rs231775, rs4553808 and rs5742909 but not rs3087243 and rs733618 were significantly related to cancer risk.
|
29794444 |
2018 |
|
Asthma
|
|
0.020 |
GeneticVariation
|
BEFREE |
For CTLA-4, AA genotype and A allele in rs3087243 and rs231725 were increased in AR with asthma group while in AR group, AA genotype and A allele in rs231725 were obviously decreased.
|
27917628 |
2016 |
|
Myasthenia Gravis
|
|
0.020 |
GeneticVariation
|
BEFREE |
There is association of rs733618 with the general susceptibility of MG, and association of rs231775 and rs3087243 with the susceptibility of ocular onset MG, but no association with the severity of MG.
|
31473094 |
2019 |
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
We investigated the association of five CTLA4 single-nucleotide polymorphisms (SNPs) (rs733618 C/T, rs4553808 A/G, rs5742909 C/T, rs231775 A/G, and rs3087243 G/A) with de novo malignancy in 1463 Chinese renal transplantation (RT) recipients who underwent a 192-month follow-up.
|
25667935 |
2015 |
|
Myasthenia Gravis
|
|
0.020 |
GeneticVariation
|
BEFREE |
A number of studies have identified Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) as a candidate gene for MG. Several recent reports have indicated that single nucleotide polymorphisms (SNPs) of CTLA-4, including rs733618, rs4553808, rs5742909, rs231775, and rs3087243 were associated with the risks of MG; however, the results were not consistent.
|
30009380 |
2018 |
|
Asthma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We genotyped CTLA4 CT60 (rs3087243) functional single nucleotide polymorphism (SNP) in children with asthma and in healthy controls and correlated the genotype data with asthma clinical data, including treatment response with inhaled corticosteroids measured by forced expiratory volume in the first second (FEV(1)).
|
19895365 |
2010 |
|
Fatigue
|
|
0.010 |
GeneticVariation
|
BEFREE |
Besides, patients carrying A allele of rs3087243 had significantly lower score of fatigue domain than those carrying G allele (2.5 ± 0.8 vs 3.9 ± 1.3, P < 0.001).
|
23432218 |
2013 |
|
Multiple Myeloma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We obtained genomic DNA from 124 patients with MM and 211 healthy controls and detected PDCD1 (rs36084323, rs41386349, and rs2227982), PDCD1LG1 (rs2297136 and rs4143815), and CTLA4 (rs733618, rs11571316, rs231775, and rs3087243) genotypes using the polymerase chain reaction-restriction fragment length polymorphism method or the TaqMan allelic discrimination real-time PCR method.
|
31620907 |
2020 |
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Also, the +6230G>A (rs3087243) polymorphism reduced breast cancer risk especially in the Chinese population under homozygous and recessive models.
|
28097051 |
2017 |
|
Childhood Osteosarcoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The current study evaluated the association of four CTLA-4 gene mutations, -1661A/G (rs4553808), -318C/T (rs5742909), +49G/A (rs231775), and CT60A/G (rs3087243), with osteosarcoma in the Chinese population.
|
21612409 |
2011 |
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
Also, the +6230G>A (rs3087243) polymorphism reduced breast cancer risk especially in the Chinese population under homozygous and recessive models.
|
28097051 |
2017 |
|
Ulcerative Colitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
CTLA-4 gene rs3087243 G > A and rs231775 G > A, and MDR1 gene rs1045642 C > T might confer an increase for UC risk.
|
26379408 |
2015 |
|
Drug-Induced Liver Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the association of 5 CTLA4 single-nucleotide polymorphisms (SNPs) (rs733618 C/T, rs4553808 A/G, rs5742909 C/T, rs231775 A/G, and rs3087243 G/A) with drug-induced liver injury (DILI) in Chinese renal transplantation (RT) recipients.
|
23300559 |
2012 |
|
Ankylosing spondylitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of the HLA-B27 antigen and the CTLA4 gene CT60/rs3087243 polymorphism with ankylosing spondylitis in Algerian population: A case-control study.
|
29675891 |
2018 |
|
Appendicitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Associations with appendicitis were found for SNPs IL-13 rs1800925 with odds ratio (OR) 6.02 (95% CI 1.52-23.78) for T/T versus C/C + T/T, for IL-17 rs2275913 with OR 2.38 (CI 1.24-4.57) for A/A vs G/G + GA, for CCL22 rs223888 with OR 0.12 (0.02-0.90), and for A/A vs G/G + GA. Signs of effect modification of age for the association with appendicitis were found for IL-13 rs1800925 and CTLA4 rs3087243.
|
31845023 |
2020 |
|
Cytomegalovirus Infections
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the present study, we have made an attempt to investigate the impact of CTLA4 single nucleotide polymorphisms (SNPs) (rs231775, rs5742909, rs11571317, rs16840252, rs4553808, rs3087243) and dinucleotide (AT)n repeat polymorphism on the incidence of symptomatic HCMV infection (disease) among 270 renal allograft recipients.
|
25356901 |
2015 |
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genotype-genotype interaction between IL-28B rs12979860 and CTLA-4 rs3087243 was found to be significantly associated with increased susceptibility to HCV infection (adjusted OR=1.509, P=0.005).
|
26079279 |
2015 |
|
Hashimoto Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of our study was to investigate whether the CTLA4 polymorphisms, including -318C/T (rs5742909), +49A/G (rs231775), and CT60 (rs3087243), were associated with GD and HD in Han Chinese adults and children.
|
27111218 |
2016 |
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The AG + AA genotypes of CTLA-4/rs3087243 statistically and antagonistically interacted with soybeans, pork and alcohol intake and were associated with CRC risk.
|
25604582 |
2015 |
|
Kidney Failure, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study was designed to investigate the impact of CTLA-4+49 A>G (rs231775), -318 C>T (rs5742909), -658 C>T (rs11571317), -1147 C>T (rs16840252), -1661 A>G (rs4553808), +6230 A>G (rs3087243) SNPs, and microsatellite (AT)n repeat polymorphism among end-stage renal disease (ESRD), acute allograft rejection (AR), and delayed graft function (DGF) cases.
|
24313821 |
2014 |
|
Chronic kidney disease stage 5
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study was designed to investigate the impact of CTLA-4+49 A>G (rs231775), -318 C>T (rs5742909), -658 C>T (rs11571317), -1147 C>T (rs16840252), -1661 A>G (rs4553808), +6230 A>G (rs3087243) SNPs, and microsatellite (AT)n repeat polymorphism among end-stage renal disease (ESRD), acute allograft rejection (AR), and delayed graft function (DGF) cases.
|
24313821 |
2014 |