|
C-reactive protein measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.
|
30388399 |
2018 |
|
C-reactive protein measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers.
|
23505291 |
2013 |
|
C-reactive protein measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.
|
21647738 |
2012 |
|
C-reactive protein measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.
|
18439548 |
2008 |
|
C-reactive protein measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.
|
18439548 |
2008 |
|
Ankylosing spondylitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The relationship between CRP gene polymorphism (rs2794521, rs3091244), ASDAS-CRP and ASDAS-ESR in ankylosing spondylitis.
|
31267817 |
2019 |
|
Ankylosing spondylitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The relationship between C-reactive protein rs3091244 polymorphism and ankylosing spondylitis.
|
26480896 |
2016 |
|
Sepsis
|
|
0.010 |
GeneticVariation
|
BEFREE |
CONCLUSIONS Our study suggests that rs1205 genetic variability in the CRP gene determines the CRP levels in sepsis of different severities, while SNP rs3091244 and SNP rs2808630 are not associated with sepsis.
|
29379005 |
2018 |
|
Septicemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
CONCLUSIONS Our study suggests that rs1205 genetic variability in the CRP gene determines the CRP levels in sepsis of different severities, while SNP rs3091244 and SNP rs2808630 are not associated with sepsis.
|
29379005 |
2018 |
|
Post-Traumatic Stress Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Multivariate analyses that controlled for white blood cell proportions, genetic principal components, age and sex, showed this association to be mediated by methylation at the AIM2 locus. rs3091244, a functional SNP in the CRP promoter region, moderated the association between lifetime trauma exposure and current PTSD severity.
|
28867284 |
2018 |
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
We have recently identified recurrent mutations at the SNP position -286 (rs3091244) in the promoter of CRP gene in several tumor types, instead suggesting that locally produced CRP is a potential driver of tumorigenesis.
|
25025473 |
2014 |
|
Carcinogenesis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We have recently identified recurrent mutations at the SNP position -286 (rs3091244) in the promoter of CRP gene in several tumor types, instead suggesting that locally produced CRP is a potential driver of tumorigenesis.
|
25025473 |
2014 |
|
Aortic Aneurysm, Abdominal
|
|
0.010 |
GeneticVariation
|
BEFREE |
C-reactive protein polymorphism rs3091244 is associated with abdominal aortic aneurysm.
|
24135623 |
2014 |
|
Ischemic stroke
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results indicated that rs3093059 and rs3091244 presented statistical associations with ischemic stroke.
|
22875596 |
2013 |
|
Senile Plaques
|
|
0.010 |
GeneticVariation
|
BEFREE |
In multivariate analyses (age- and APOE-adjusted), non-neuritic SP were associated with the high-CRP TA-genotype (3.0% prevalence) of rs3091244 and CA-genotype (10.8%) of rs3093075 compared to common genotypes.
|
21831326 |
2011 |
|
Fatigue
|
|
0.010 |
GeneticVariation
|
BEFREE |
In a large cohort of BCSs the investigated SNPs in inflammation-related genes were not associated with fatigue, though subset analyses indicated an association between the CRP SNP (rs3091244) and serum hsCRP.
|
21496483 |
2011 |
|
Metabolic Syndrome X
|
|
0.010 |
GeneticVariation
|
BEFREE |
Independent associations between the combined ICAM1-CRP (rs5491 and rs3091244) genotypes and MetS were found by multivariate analysis (P = .005).
|
20494378 |
2010 |
|
Coronary heart disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Post hoc analysis suggests that the AA genotype of the triallelic SNP rs3091244, after adjustment for covariates, was associated with prevalent coronary heart disease in the non-Hispanic white population sample.
|
17101857 |
2006 |
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Post hoc analysis suggests that the AA genotype of the triallelic SNP rs3091244, after adjustment for covariates, was associated with prevalent coronary heart disease in the non-Hispanic white population sample.
|
17101857 |
2006 |
|
Coronary Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Post hoc analysis suggests that the AA genotype of the triallelic SNP rs3091244, after adjustment for covariates, was associated with prevalent coronary heart disease in the non-Hispanic white population sample.
|
17101857 |
2006 |
|
Atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We concluded that rs3091244, rs1130864 and the T-T-G haplotype are genetic markers for elevated basal CRP levels. rs1800947 and the C-C-C haplotype appear to be susceptibility markers for atherosclerosis, but this requires confirmation.
|
16832152 |
2006 |
|
Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We concluded that rs3091244, rs1130864 and the T-T-G haplotype are genetic markers for elevated basal CRP levels. rs1800947 and the C-C-C haplotype appear to be susceptibility markers for atherosclerosis, but this requires confirmation.
|
16832152 |
2006 |