rs3132468, MICB

N. diseases: 5
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Severe Dengue
CUI: C0019100
Disease: Severe Dengue
0.710 GeneticVariation BEFREE A previous genome-wide association study identified 2 susceptibility loci for severe dengue at MICB rs3132468 and PLCE1 rs3740360 and further work showed these mutations to be also associated with less severe clinical presentations. 28599625 2017
Dengue Shock Syndrome
CUI: C0376300
Disease: Dengue Shock Syndrome
0.710 GeneticVariation BEFREE A recent genome-wide association study (GWAS) identified susceptibility loci for dengue shock syndrome (DSS) at MICB rs3132468 and PLCE1 rs3740360. 23536857 2013
Dengue Shock Syndrome
CUI: C0376300
Disease: Dengue Shock Syndrome
0.710 GeneticVariation GWASDB Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1. 22001756 2011
Severe Dengue
CUI: C0019100
Disease: Severe Dengue
0.710 GeneticVariation GWASCAT Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1. 22001756 2011
DOSAGE-SENSITIVE SEX REVERSAL
CUI: C1848296
Disease: DOSAGE-SENSITIVE SEX REVERSAL
0.020 GeneticVariation BEFREE Together with previous association studies, we conclude that rs3132468-C at MICB and rs3765524-C at PLCE1 confer risk of DSS in Southeast Asians. 24884822 2014
Dejerine-Sottas Disease (disorder)
CUI: C0011195
Disease: Dejerine-Sottas Disease (disorder)
0.020 GeneticVariation BEFREE Together with previous association studies, we conclude that rs3132468-C at MICB and rs3765524-C at PLCE1 confer risk of DSS in Southeast Asians. 24884822 2014
Dengue Fever
CUI: C0011311
Disease: Dengue Fever
0.020 GeneticVariation BEFREE The reported DSS-risk alleles were significantly associated with DSS in Thai patients with dengue (one-sided P = 0.0213 and odds ratio [OR] = 1.58 for rs3132468-C and one-sided P = 0.0252 and OR = 1.49 for rs3765524-C). 24884822 2014
Dengue Fever
CUI: C0011311
Disease: Dengue Fever
0.020 GeneticVariation BEFREE This study confirms that the MICB rs3132468 and PLCE1 rs3740360 risk genotypes are not only associated with DSS, but are also associated with less severe clinical phenotypes of dengue, as well as with dengue in infants. 23536857 2013
DOSAGE-SENSITIVE SEX REVERSAL
CUI: C1848296
Disease: DOSAGE-SENSITIVE SEX REVERSAL
0.020 GeneticVariation BEFREE This study confirms that the MICB rs3132468 and PLCE1 rs3740360 risk genotypes are not only associated with DSS, but are also associated with less severe clinical phenotypes of dengue, as well as with dengue in infants. 23536857 2013
Dejerine-Sottas Disease (disorder)
CUI: C0011195
Disease: Dejerine-Sottas Disease (disorder)
0.020 GeneticVariation BEFREE This study confirms that the MICB rs3132468 and PLCE1 rs3740360 risk genotypes are not only associated with DSS, but are also associated with less severe clinical phenotypes of dengue, as well as with dengue in infants. 23536857 2013