The HLA-G polymorphism at 3'UTR 14bp INDEL (rs371194629) and +3142G/C (rs1063320) were studied in 383 HNSCC patients and 383 ethnically similar-aged healthy controls in North Indian population.
<i>HLA-G</i> 3'UTR-2, which contains rs1610696-<i>G/G</i> and rs371194629-<i>Ins/Ins</i> polymorphisms, was associated with increased risk of G3-4 neutropenia (OR = 3.92, <i>p</i> = 0.017) and neurotoxicity (OR = 11.29, <i>p</i> = 0.009).
Because the HLA-G 14 bp-insertion/deletion polymorphism (rs371194629) has been associated with the magnitude of HLA-G expression, we evaluated this polymorphism in the recognized evolutionary forms of chronic HBV infection.
<i>HLA-G</i> 3'UTR-2, which contains rs1610696-<i>G/G</i> and rs371194629-<i>Ins/Ins</i> polymorphisms, was associated with increased risk of G3-4 neutropenia (OR = 3.92, <i>p</i> = 0.017) and neurotoxicity (OR = 11.29, <i>p</i> = 0.009).
Different studies have analyzed the role of rs371194629 in hepatic injury, with either hepatotropic virus infection (i.e., HBV or HCV) or hepatocellular carcinoma (also induced by viral infection).
HLA-G encodes two potentially functional polymorphisms in the 3' untranslated region, 14bp insertion/deletion (14bp indel, rs371194629) and a single nucleotide polymorphism rs1063320, previously reported to affect HLA-G expression level or splicing isoform and to be associated with susceptibility to systemic lupus erythematosus (SLE).
Different studies have analyzed the role of rs371194629 in hepatic injury, with either hepatotropic virus infection (i.e., HBV or HCV) or hepatocellular carcinoma (also induced by viral infection).
This study investigates the involvement of a 14-bp deletion polymorphism (rs371194629) at the 3' untranslated region of HLA-G in the context of T1DM and age of onset.