White Blood Cell Count procedure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Monocyte count procedure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
Lymphocyte Count measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
Monocyte count result
|
|
0.700 |
GeneticVariation
|
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
Age related macular degeneration
|
|
0.090 |
GeneticVariation
|
BEFREE |
PLEKHA1 958A/G polymorphism was associated with a decreased AMD risk (additive model: aOR=0.722, 95% CI=0.450-0.979, P=0.019; allele model: aOR=0.883, 95% CI=0.736-0.992, P=0.014), while all other polymorphisms were associated with an increased AMD risk (CX3CR1 839C/T, additive model: aOR=2.682, 95% CI=1.119-5.709, P=0.022, recessive model: aOR=2.729, 95% CI=1.141-6.048, P=0.010; CX3CR1 745G/A, additive model: aOR=2.614, 95% CI=1.231-6.012, P=0.020, recessive model: aOR=2.340, 95% CI=1.227-5.993, P=0.011; VEGFA +674C/T, additive model: aOR=1.601, 95% CI=1.253-2.179, P<0.001, dominant model: aOR=1.287, 95% CI=1.058-1.570, P<0.001, allele model: OR=1.220, 95% CI=1.118-1.427, P<0.001; VEGFA +936C/T, additive model: aOR=1.509, 95% CI=1.105-2.311, P<0.001, recessive model: aOR=1.432, 95% CI=1.027-2.192, P=0.009, dominant model: aOR=1.207, 95% CI=1.031-1.514, P0.001, allele model: aOR=1.216, 95% CI=1.062-1.408, P<0.001).
|
29565837 |
2018 |
Age related macular degeneration
|
|
0.090 |
GeneticVariation
|
BEFREE |
No obvious differences were observed in the genotypes of rs3732378</span> polymorphism between case and control groups (P>0.05), but A allele of it could increase the risk of AMD (P=0.025, OR=2.391, 95% CI=1.092-5.237).
|
26464724 |
2015 |
Age related macular degeneration
|
|
0.090 |
GeneticVariation
|
BEFREE |
Significant evidence for a relationship between T280M and V249I variants in CX3CR1 in the homozygote state with increased susceptibility to AMD was reported.
|
26305531 |
2015 |
Age related macular degeneration
|
|
0.090 |
GeneticVariation
|
BEFREE |
CX3CR1 (T280M and V249I) and PLEKHA1 (A320T) polymorphisms were not found to be associated with AMD.
|
25050486 |
2014 |
Age related macular degeneration
|
|
0.090 |
GeneticVariation
|
BEFREE |
If replicated in other populations, these findings would support a role for CX3CR1 in AMD but also suggest that its role may involve mechanisms that are independent of the T280M/V249I variations.
|
24287500 |
2014 |
Age related macular degeneration
|
|
0.090 |
GeneticVariation
|
BEFREE |
The T280M polymorphism was not associated with either AMD Grades 2-3 or AMD Grades 4 or 5.
|
22816662 |
2012 |
Age related macular degeneration
|
|
0.090 |
GeneticVariation
|
BEFREE |
Our study exclude an association between the T280M of the CX3CR1 gene and exudative AMD in a French population.
|
21621535 |
2011 |
Age related macular degeneration
|
|
0.090 |
GeneticVariation
|
BEFREE |
CX3CR1 V249I and T280M and the HTRA1 promoter SNP were significantly associated with the risk of exudative AMD.
|
20538655 |
2010 |
Age related macular degeneration
|
|
0.090 |
GeneticVariation
|
BEFREE |
Furthermore, lower CX3CR1 protein expression was observed in the maculae of AMD eyes bearing T/M280 compared with the controls bearing T/T280.
|
15208270 |
2004 |
Coronary Artery Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
The analysis showed that the 280M allele carriers of the CX3CR1 T280M polymorphism decreased the risk of AS and coronary artery disease (CAD) in the heterozygous state but increased the risk of ischemic cerebrovascular disease (ICVD) in the homozygote state.
|
25221380 |
2014 |
Coronary Artery Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
Association of V249I and T280M polymorphisms in the chemokine receptor CX3CR1 gene with early onset of coronary artery disease among North Indians.
|
22731642 |
2012 |
Coronary Artery Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
The CX3CR1 gene encodes the fractalkine (CX3CL1) receptor and has two coding single-nucleotide polymorphisms, V249I and T280M, linked to a lower risk of other inflammatory diseases such as coronary artery disease (CAD) and asthma.
|
20523302 |
2011 |
Coronary Artery Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
Although we do not believe that the retrieved odds ratios render the T280M polymorphism a candidate genetic marker for clinical applications, we do believe that the above genotype-phenotype interaction is indicative of the strong associations between FKN-induced pathways and CAD.
|
19439304 |
2009 |
Coronary Artery Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
The OR of T280M for CAD was 0.83 (95% CI=0.66-1.04, p=0.11).
|
19628406 |
2009 |
Coronary Artery Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
We examined the frequencies of V249I and T280M among early-onset CAD patients (G1; n = 149; <50 years), late-onset CAD patients (G2; n = 150; >65 years) and healthy controls (HC; n = 149, 47-93 years) without known CAD risk factors.
|
18609106 |
2008 |
Coronary Artery Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
We investigated the effect of 5 common variations of chemokine and chemokine receptor genes (SDF1-3'A, CCR5-delta32, CCR2-64I, CX3CR1-V249I and CX3CR1-T280M) on predisposition to CAD.
|
16480760 |
2007 |
Coronary Artery Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
The genotypes of the V249I and T280M polymorphisms were determined in 1152 patients with suspected CAD.720 (62.5%) individuals showed significant CAD with an ACS prevalence of 59.3%.
|
15886814 |
2005 |
Atherosclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
We aimed to investigate the associations of fractalkine receptor (CX3CR1) V249I, T280M and CCR5-59029 A/G gene polymorphisms in chronic renal failure (CRF) subjects undergoing hemodialysis and to evaluate possible associations of these polymorphisms with hypertension (HT), diabetes mellitus (DM) and atherosclerosis (AS).
|
27118566 |
2016 |
Arteriosclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
We aimed to investigate the associations of fractalkine receptor (CX3CR1) V249I, T280M and CCR5-59029 A/G gene polymorphisms in chronic renal failure (CRF) subjects undergoing hemodialysis and to evaluate possible associations of these polymorphisms with hypertension (HT), diabetes mellitus (DM) and atherosclerosis (AS).
|
27118566 |
2016 |
Arteriosclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The present meta-analysis suggests that the CX3CR1 T280M and V249I polymorphisms are associated with the susceptibility to AS.
|
25221380 |
2014 |
Atherosclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The present meta-analysis suggests that the CX3CR1 T280M and V249I polymorphisms are associated with the susceptibility to AS.
|
25221380 |
2014 |