rs3732581, PARL

N. diseases: 9
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
0.020 GeneticVariation BEFREE We observed no evidence for previously reported T2D association with Val262Leu or PARL using array and fine-map genomic and expression data. 25117150 2014
Diabetes Mellitus, Non-Insulin-Dependent
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
0.020 GeneticVariation BEFREE We observed no association between Leu262Val variant and T2DM nor was there an association with plasma insulin concentrations or BMI. 19185381 2009
Hyperinsulinism
CUI: C0020459
Disease: Hyperinsulinism
0.010 GeneticVariation BEFREE The SNP variant (Leu262Val) in PARL has been shown to be associated with hyperinsulinaemia in an age-dependent manner in a US non-diabetic, cohort. 19185381 2009
Coronary Arteriosclerosis
CUI: C0010054
Disease: Coronary Arteriosclerosis
0.010 GeneticVariation BEFREE Association of PARL rs3732581 genetic variant with insulin levels, metabolic syndrome and coronary artery disease. 18758826 2008
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.010 GeneticVariation BEFREE No significant associations were observed between rs3732581 and levels of plasma insulin, glucose, BMI or MetS in either population. 18758826 2008
Cardiovascular Diseases
CUI: C0007222
Disease: Cardiovascular Diseases
0.010 GeneticVariation BEFREE The aim of the current study was to investigate the associations between rs3732581 and levels of plasma insulin, metabolic syndrome (MetS) and its components, and cardiovascular disease. 18758826 2008
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.010 GeneticVariation BEFREE Association of PARL rs3732581 genetic variant with insulin levels, metabolic syndrome and coronary artery disease. 18758826 2008
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.010 GeneticVariation BEFREE Association of PARL rs3732581 genetic variant with insulin levels, metabolic syndrome and coronary artery disease. 18758826 2008
Diabetes
CUI: C0011847
Disease: Diabetes
0.010 GeneticVariation BEFREE In 1,031 human subjects, an amino acid substitution (Leu262Val) in PSARL was associated with increased plasma insulin concentration, a key risk factor for diabetes. 15729572 2005
Diabetes Mellitus
CUI: C0011849
Disease: Diabetes Mellitus
0.010 GeneticVariation BEFREE In 1,031 human subjects, an amino acid substitution (Leu262Val) in PSARL was associated with increased plasma insulin concentration, a key risk factor for diabetes. 15729572 2005