rs3753584, MTHFR;CLCN6

N. diseases: 10
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Diastolic blood pressure measurement
CUI: C1305849
Disease: Diastolic blood pressure measurement
0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
Systolic Pressure
CUI: C0871470
Disease: Systolic Pressure
0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
Mean blood pressure
CUI: C0428886
Disease: Mean blood pressure
0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
Systolic blood pressure measurement
CUI: C1306620
Disease: Systolic blood pressure measurement
0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
Diastolic blood pressure
CUI: C0428883
Disease: Diastolic blood pressure
0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.010 GeneticVariation BEFREE In summary, our findings suggested that MTHFR rs3753584, rs9651118 and rs1801133 polymorphisms may affect the risk of HCC in Chinese Han population. 31694048 2019
Colon Carcinoma
CUI: C0699790
Disease: Colon Carcinoma
0.010 GeneticVariation BEFREE In a stratified analysis by CRC region, we found <i>MTHFR</i> rs3753584 T>C and rs9651118 T>C polymorphisms were associated with the increased risk of colon cancer. 28969008 2017
Rectal Carcinoma
CUI: C0007113
Disease: Rectal Carcinoma
0.010 GeneticVariation BEFREE In addition, a significantly increased risk of rectum cancer associated with <i>MTHFR</i> rs3753584 T>C polymorphism was overt. 28969008 2017
Malignant tumor of colon
CUI: C0007102
Disease: Malignant tumor of colon
0.010 GeneticVariation BEFREE In a stratified analysis by CRC region, we found <i>MTHFR</i> rs3753584 T>C and rs9651118 T>C polymorphisms were associated with the increased risk of colon cancer. 28969008 2017
Squamous cell carcinoma of esophagus
CUI: C0279626
Disease: Squamous cell carcinoma of esophagus
0.010 GeneticVariation BEFREE Our results demonstrated that MTHFR rs1801133 C>T was associated with the risk of ESCC; however, MTHFR rs4845882 G>A and rs4846048 A>G SNPs were associated with the decreased risk of ESCC, and MTHFR rs3753584 A>G and rs9651118 T>C SNPs were not associated with ESCC risk. 24687778 2014