|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
For example, we characterized that the Crohn's disease risk variant for rs3810936 increases NFKB1 binding and results in altered gene expression.
|
30254052 |
2018 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
Our analysis suggested that rs3810936 polymorphism was significantly associated with decreased risk of Crohn's disease (CD) and ulcerative colitis (UC).
|
29873318 |
2018 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
Our results confirmed a significant association of CD with the following previously reported risk loci: rs3810936 in TNFSF15 (OR=1.83, p<2.2×10(-16)), rs76418789 in IL23R (OR=0.47, p=1.14×10(-8)) and rs2241880 in ATG16L1 (OR=1.30, p=5.28×10(-6)).
|
25731871 |
2016 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
The minor T alleles and the TT genotypes of rs10114470 and rs3810936 were significantly protectively associated with both CD and UC.
|
25501099 |
2014 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
According to the subgroup analysis by ethnicity, except for rs4263839 in Caucasian and rs4979462 in Asian, all the rest investigated TNFSF15 polymorphisms were associated with CD risk and rs3810936 and rs7848647 polymorphism in Asian as well as rs6478108 polymorphism in Caucasian were associated with UC risk.
|
25028192 |
2014 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
GWASDB |
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
21102463 |
2010 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
GWASCAT |
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
21102463 |
2010 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
GWASDB |
Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease.
|
16221758 |
2005 |
|
Ulcerative Colitis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our analysis suggested that rs3810936 polymorphism was significantly associated with decreased risk of Crohn's disease (CD) and ulcerative colitis (UC).
|
29873318 |
2018 |
|
Ulcerative Colitis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the association of TNFSF15 gene polymorphisms located in the promoter region, including rs6478108 (G/A -9706) and rs3810936 (G/A -15524) in Iranian patients with UC.
|
30556168 |
2018 |
|
Ulcerative Colitis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The minor T alleles and the TT genotypes of rs10114470 and rs3810936 were significantly protectively associated with both CD and UC.
|
25501099 |
2014 |
|
Ulcerative Colitis
|
|
0.040 |
GeneticVariation
|
BEFREE |
According to the subgroup analysis by ethnicity, except for rs4263839 in Caucasian and rs4979462 in Asian, all the rest investigated TNFSF15 polymorphisms were associated with CD risk and rs3810936 and rs7848647 polymorphism in Asian as well as rs6478108 polymorphism in Caucasian were associated with UC risk.
|
25028192 |
2014 |
|
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our findings indicate that gene polymorphisms (rs3810936, rs7848647) of TL1A might correlate with lupus.
|
31081141 |
2019 |
|
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation
|
BEFREE |
Logistic regression analysis showed that rs3810936 and rs4979462 of TNFSF15, histories of chilblain and wet living environment were independently associated with the risk of SLE (all P < 0.05).The current results suggested that TNFSF15 (rs3810936 and rs4979462) SNPs may confer susceptibility to SLE risk, which were significantly associated with the clinical phenotypes of SLE.
|
29803925 |
2018 |
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, these findings indicated an association between TL1A rs3810936, rs7848647 variation and the susceptibility of RA in a sample of Chinese individuals, and TL1A may correlate with severity of RA.
|
30488533 |
2019 |
|
Lupus Vulgaris
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings indicate that gene polymorphisms (rs3810936, rs7848647) of TL1A might correlate with lupus.
|
31081141 |
2019 |
|
Pouchitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
SNP genotyping was performed for 8 SNPs reportedly associated with UCAC and pouchitis, namely: ELF1 (rs7329174), FCGR2A, (rs1801274), interleukin-1β (IL-1B; rs1143627), ITLN1 (rs2274910), MHC (rs7765379), TNFα (rs1799964), TNFSF15 (rs3810936), and UHMK1 (rs768910), using TaqMan genotyping technologies.
|
31671425 |
2019 |
|
Lupus Erythematosus, Discoid
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings indicate that gene polymorphisms (rs3810936, rs7848647) of TL1A might correlate with lupus.
|
31081141 |
2019 |
|
Lupus Erythematosus
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings indicate that gene polymorphisms (rs3810936, rs7848647) of TL1A might correlate with lupus.
|
31081141 |
2019 |
|
Chilblains
|
|
0.010 |
GeneticVariation
|
BEFREE |
Logistic regression analysis showed that rs3810936 and rs4979462 of TNFSF15, histories of chilblain and wet living environment were independently associated with the risk of SLE (all P < 0.05).The current results suggested that TNFSF15 (rs3810936 and rs4979462) SNPs may confer susceptibility to SLE risk, which were significantly associated with the clinical phenotypes of SLE.
|
29803925 |
2018 |
|
Inflammatory Bowel Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three extensively investigated polymorphisms (rs3810936, rs7848647, and rs6478108) in tumor necrosis factor super family member 15 (TNFSF15) gene have been implicated in risk for inflammatory bowel disease (IBD).
|
29873318 |
2018 |
|
Ankylosing spondylitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Stratification according to AS status did not reveal a difference concerning the association with TNFSF15-rs3810936.
|
26200500 |
2015 |
|
Acute anterior uveitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study shows an association between TNFSF15-rs3810936 and AAU and suggests that the TL1A/DR3 pathway may be implicated in the pathogenesis of this disease.
|
26200500 |
2015 |