|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
GWASDB |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
|
21378990 |
2011 |
|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
|
21378990 |
2011 |
|
response to bronchodilator
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
|
26634245 |
2015 |
|
Smoking Behaviors
|
|
0.700 |
GeneticVariation
|
GWASDB |
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.
|
20418888 |
2010 |
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
In the present study, we aimed to examine the role of two single-nucleotide polymorphisms (SNPs), rs3825807 and rs11556924, located in the ADAMTS7 and ZC3HC1 genes, respectively, associated with CAD in published GWASs in European populations and their possible contribution to the development of coronary atherosclerosis and cerebral LA atherosclerosis in a case-control study of an the Iranian population.
|
31679296 |
2019 |
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
The lead CAD-associated single-nucleotide polymorphism rs3825807 at the ADAMTS7 locus was genotyped.
|
29089340 |
2017 |
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
Functional studies have shown that a CAD-associated polymorphism (rs3825807) affects ADAMTS7 maturation and vascular smooth muscular cell (VSMC) migration.
|
27614204 |
2016 |
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
We found that ADAMTS7 rs3825807 was associated with susceptibility to CAD in a Chinese population [odds ratio (OR) = 1.15, 95 % confidence interval (CI) = 1.05-1.26, P = 0.002].
|
26189211 |
2016 |
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
Besides the CAD/MI SNP at 9p21 (rs4977574, P = 3.1 × 10(-10)), two additional loci at ADAMTS7 (rs3825807, P = 6.5 × 10(-6)) and at PHACTR1 (rs12526453, P = 1.0 × 10(-3)) show a nominally significant association with coronary artery calcification with MI/CAD risk alleles increasing the degree of arterial calcification.
|
23561647 |
2013 |
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
The results of our study indicate that rs3825807 has an effect on ADAMTS7 maturation, thrombospondin-5 cleavage, and VSMC migration, with the variant associated with protection from atherosclerosis and CAD rendering a reduction in ADAMTS7 function.
|
23415669 |
2013 |
|
Atherosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
In the present study, we aimed to examine the role of two single-nucleotide polymorphisms (SNPs), rs3825807 and rs11556924, located in the ADAMTS7 and ZC3HC1 genes, respectively, associated with CAD in published GWASs in European populations and their possible contribution to the development of coronary atherosclerosis and cerebral LA atherosclerosis in a case-control study of an the Iranian population.
|
31679296 |
2019 |
|
Arteriosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
In the present study, we aimed to examine the role of two single-nucleotide polymorphisms (SNPs), rs3825807 and rs11556924, located in the ADAMTS7 and ZC3HC1 genes, respectively, associated with CAD in published GWASs in European populations and their possible contribution to the development of coronary atherosclerosis and cerebral LA atherosclerosis in a case-control study of an the Iranian population.
|
31679296 |
2019 |
|
Atherosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Therefore, this study was designed to evaluate the effect of rs3825807, a non-synonymous variant in the prodomain of the ADAMTS7 protease, on CAD risk and atherosclerosis severity in a Chinese population.
|
26189211 |
2016 |
|
Arteriosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Therefore, this study was designed to evaluate the effect of rs3825807, a non-synonymous variant in the prodomain of the ADAMTS7 protease, on CAD risk and atherosclerosis severity in a Chinese population.
|
26189211 |
2016 |
|
Arteriosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
The results of our study indicate that rs3825807 has an effect on ADAMTS7 maturation, thrombospondin-5 cleavage, and VSMC migration, with the variant associated with protection from atherosclerosis and CAD rendering a reduction in ADAMTS7 function.
|
23415669 |
2013 |
|
Atherosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
The results of our study indicate that rs3825807 has an effect on ADAMTS7 maturation, thrombospondin-5 cleavage, and VSMC migration, with the variant associated with protection from atherosclerosis and CAD rendering a reduction in ADAMTS7 function.
|
23415669 |
2013 |
|
Ischemic stroke
|
|
0.020 |
GeneticVariation
|
BEFREE |
ADAMTS7 polymorphisms of both rs7173743 and rs3825807 were associated with carotid plaque vulnerability but not the prevalence of ischemic stroke.
|
31651847 |
2019 |
|
Ischemic stroke
|
|
0.020 |
GeneticVariation
|
BEFREE |
Also, the mutated rs3825807 G allele, as well as the mutated rs11634042 T allele of ADAMTS7, are linked to a significant reduction of ADAMTS7 in patients with IS.
|
31460868 |
2019 |
|
Myocardial Infarction
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our finding suggest that <i>ADAMTS7</i> tagSNP rs3825807 contributes to MI susceptibility in the Chinese Han population.
|
31292280 |
2019 |
|
Myocardial Infarction
|
|
0.020 |
GeneticVariation
|
BEFREE |
Besides the CAD/MI SNP at 9p21 (rs4977574, P = 3.1 × 10(-10)), two additional loci at ADAMTS7 (rs3825807, P = 6.5 × 10(-6)) and at PHACTR1 (rs12526453, P = 1.0 × 10(-3)) show a nominally significant association with coronary artery calcification with MI/CAD risk alleles increasing the degree of arterial calcification.
|
23561647 |
2013 |
|
Peripheral Arterial Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
This is the first report of the relationship between PAD and ADAMTS7 expression and the effects of the rs1994016 and rs3825807 variants on PAD development.
|
28205274 |
2018 |
|
Peripheral Vascular Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic variants rs1994016 and rs3825807 in ADAMTS7 affect its mRNA expression in atherosclerotic occlusive peripheral arterial disease.
|
28205274 |
2018 |