|
Adenocarcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
After adjusting for known risk loci, rs2736100 and rs401681, we identified a new, independent lung cancer susceptibility variant in LPCAT1: rs139852726 (OR = 0.46, P = 4.73×10(-9)), and three new adenocarcinoma risk variants in TERT: rs61748181 (OR = 0.53, P = 2.64×10(-6)), rs112290073 (OR = 1.85, P = 1.27×10(-5)), rs138895564 (OR = 2.16, P = 2.06×10(-5); among young cases, OR = 3.77, P = 8.41×10(-4)).
|
26590902 |
2016 |
|
Adenocarcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Additionally, in a subgroup analysis by histology type, the CLPTM1L rs401681 polymorphism was found to significantly decrease the risks of both adenocarcinoma and squamous cell carcinoma of the lung in all genetic models.
|
24634236 |
2014 |
|
Adenocarcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
In addition, we find both rs402710 and rs401681 conferred significantly greater risks for adenocarcinoma and squamous cell carcinoma when stratified by histological type of tumors.
|
24907075 |
2014 |
|
Adenocarcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Stratification analysis by histology type indicated that rs401681 T genotypes were associated with a significantly reduced risk of both adenocarcinoma and squamous cell carcinoma.
|
24386361 |
2013 |
|
Adenocarcinoma of lung (disorder)
|
|
0.810 |
GeneticVariation
|
GWASDB |
A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma.
|
19836008 |
2009 |
|
Adenocarcinoma of lung (disorder)
|
|
0.810 |
GeneticVariation
|
GWASCAT |
Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations.
|
31326317 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
|
0.810 |
GeneticVariation
|
BEFREE |
Gene variations rs2736100 and rs2853676 in TERT and rs401681 and rs31489 in CLPTM1L had significant direct associations on lung adenocarcinoma without indirect effects through nicotine dependence.
|
25233467 |
2014 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among these SNPs, three were significantly associated with PDAC risk after Bonferroni correction (P < 2.5E-03) including rs7779540 (at 7q36.2, P = 3.89E-06, OR = 2.59, 95%CI: 1.73-3.87), rs10919791 (at 1q32.1, P = 6.07E-05, OR = 1.52, 95%CI: 1.24-1.86) and rs401681 (at 5p15.33, P = 5.15E-04, OR = 1.42, 95%CI: 1.17-1.73).
|
28988600 |
2018 |
|
Basal Cell Cancer
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma.
|
24403052 |
2014 |
|
Basal Cell Cancer
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Sequence variants at the TERT-CLPTM1L locus associate with many cancer types.
|
19151717 |
2009 |
|
Basal Cell Cancer
|
|
0.700 |
GeneticVariation
|
GWASCAT |
New basal cell carcinoma susceptibility loci.
|
25855136 |
2015 |
|
Basal cell carcinoma
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma.
|
24403052 |
2014 |
|
Basal cell carcinoma
|
|
0.700 |
GeneticVariation
|
GWASCAT |
New basal cell carcinoma susceptibility loci.
|
25855136 |
2015 |
|
Basal cell carcinoma
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Sequence variants at the TERT-CLPTM1L locus associate with many cancer types.
|
19151717 |
2009 |
|
Basal Cell Neoplasm
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Sequence variants at the TERT-CLPTM1L locus associate with many cancer types.
|
19151717 |
2009 |
|
Basal Cell Neoplasm
|
|
0.700 |
GeneticVariation
|
GWASCAT |
New basal cell carcinoma susceptibility loci.
|
25855136 |
2015 |
|
Basal Cell Neoplasm
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma.
|
24403052 |
2014 |
|
Bladder Neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
Results showed that heterogeneity in ORs of tumor categories was not significant for either rs11892031 or rs401681 (p>0.05), indicating that the two SNPs seemingly do not associate with tumor grade and stage of bladder cancer in our study population.
|
25347272 |
2014 |
|
Carcinogenesis
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results suggested that the rs401681 polymorphism contributes to lung carcinogenesis only in patients harboring an EGFR mutation.
|
29033187 |
2017 |
|
Carcinoma of bladder
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies multiple loci associated with bladder cancer risk.
|
24163127 |
2014 |
|
Carcinoma of bladder
|
|
0.710 |
GeneticVariation
|
BEFREE |
Results showed that heterogeneity in ORs of tumor categories was not significant for either rs11892031 or rs401681 (p>0.05), indicating that the two SNPs seemingly do not associate with tumor grade and stage of bladder cancer in our study population.
|
25347272 |
2014 |
|
Carcinoma of bladder
|
|
0.710 |
GeneticVariation
|
GWASCAT |
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
|
20972438 |
2010 |
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our findings demonstrated that rs402710 and rs401681 are risk-conferring factors for the development of lung cancer.
|
24907075 |
2014 |
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
After adjusting for known risk loci, rs2736100 and rs401681, we identified a new, independent lung cancer susceptibility variant in LPCAT1: rs139852726 (OR = 0.46, P = 4.73×10(-9)), and three new adenocarcinoma risk variants in TERT: rs61748181 (OR = 0.53, P = 2.64×10(-6)), rs112290073 (OR = 1.85, P = 1.27×10(-5)), rs138895564 (OR = 2.16, P = 2.06×10(-5); among young cases, OR = 3.77, P = 8.41×10(-4)).
|
26590902 |
2016 |
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |