|
Malignant Head and Neck Neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
The purpose of this hospital-based case-control study of patients in northern China was to explore the association between two single-nucleotide polymorphisms (SNPs) rs401681 in <i>TERT</i> and rs2736100 in <i>CLPTM1L</i> and the risk of head and neck cancer.
|
31429604 |
2019 |
|
Head and Neck Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The purpose of this hospital-based case-control study of patients in northern China was to explore the association between two single-nucleotide polymorphisms (SNPs) rs401681 in <i>TERT</i> and rs2736100 in <i>CLPTM1L</i> and the risk of head and neck cancer.
|
31429604 |
2019 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among these SNPs, three were significantly associated with PDAC risk after Bonferroni correction (P < 2.5E-03) including rs7779540 (at 7q36.2, P = 3.89E-06, OR = 2.59, 95%CI: 1.73-3.87), rs10919791 (at 1q32.1, P = 6.07E-05, OR = 1.52, 95%CI: 1.24-1.86) and rs401681 (at 5p15.33, P = 5.15E-04, OR = 1.42, 95%CI: 1.17-1.73).
|
28988600 |
2018 |
|
Carcinogenesis
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results suggested that the rs401681 polymorphism contributes to lung carcinogenesis only in patients harboring an EGFR mutation.
|
29033187 |
2017 |
|
Esophageal carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the genetic model analyses, we found that the minor alleles "T" of rs401681, "A" of rs10088262, and "C" of rs4924935 may reduce the risk of EC. rs401681 has previously been reported to be associated with EC.
|
26304507 |
2016 |
|
Nicotine Dependence
|
|
0.010 |
GeneticVariation
|
BEFREE |
Gene variations rs2736100 and rs2853676 in TERT and rs401681 and rs31489 in CLPTM1L had significant direct associations on lung adenocarcinoma without indirect effects through nicotine dependence.
|
25233467 |
2014 |
|
Squamous cell carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Additionally, in a subgroup analysis by histology type, the CLPTM1L rs401681 polymorphism was found to significantly decrease the risks of both adenocarcinoma and squamous cell carcinoma of the lung in all genetic models.
|
24634236 |
2014 |
|
Lymphoma, Non-Hodgkin
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the pleiotropy analysis, six risk variants for other cancers were associated with NHL risk, including variants for lung (rs401681 in TERT: OR per C allele=0.89, p=3.7 × E-03; rs4975616 in TERT: OR per A allele=0.90, p=0.01; rs3131379 in MSH5: OR per T allele=1.16, p=0.03), prostate (rs7679673 in TET2: OR per C allele=0.89, p=5.7 × E-03; rs10993994 in MSMB: OR per T allele=1.09, p=0.04), and breast (rs3817198 in LSP1: OR per C allele=1.12, p=0.01) cancers, but none of these associations remained significant after multiple test correction.
|
24598796 |
2014 |
|
Bladder Neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
Results showed that heterogeneity in ORs of tumor categories was not significant for either rs11892031 or rs401681 (p>0.05), indicating that the two SNPs seemingly do not associate with tumor grade and stage of bladder cancer in our study population.
|
25347272 |
2014 |
|
Skin carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Single-nucleotide polymorphism of CLPTM1L-rs401681(C > T) at the 5p15.33 locus is significantly associated with cancer risk as reported in genome-wide association studies, but the reported studies for non-melanoma skin cancer (NMSC) are inconclusive.
|
22893025 |
2013 |
|
Malignant neoplasm of skin
|
|
0.010 |
GeneticVariation
|
BEFREE |
We evaluated the associations between 39 SNPs, including 38 tag-SNPs in telomere-related genes (TERT, TRF1, TRF2, TNKS2, and POT1) and one SNP (rs401681) in the TERT-CLPTM1L locus which has been identified as a susceptibility locus to skin cancer in the previous GWAS, and the risk of skin cancer in a case-control study of Caucasians nested within the Nurses' Health Study (NHS) among 218 melanoma cases, 285 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCC) cases, and 870 controls.
|
21116649 |
2011 |
|
Squamous cell carcinoma of the head and neck
|
|
0.010 |
GeneticVariation
|
BEFREE |
Compared with the CC genotypes of each polymorphism, the associations of a slightly reduced risk of SCCHN with the variant genotypes of CT + TT of both polymorphisms were approaching statistical significance [Odds ratio (OR) = 0.90, 95% confidence interval (CI) = 0.76-1.08 for TERT-rs2736098 and OR = 0.86, 95% CI = 0.71-1.04 for CLPTM1L-rs401681, respectively].
|
20802237 |
2010 |
|
Cervix carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We tested rs401681 for association with 16 additional cancer types in over 30,000 cancer cases and 45,000 controls and found association with lung cancer (OR = 1.15, P = 7.2 x 10(-8)) and urinary bladder, prostate and cervix cancer (ORs = 1.07-1.31, all P < 4 x 10(-4)).
|
19151717 |
2009 |
|
cervical cancer
|
|
0.010 |
GeneticVariation
|
BEFREE |
We tested rs401681 for association with 16 additional cancer types in over 30,000 cancer cases and 45,000 controls and found association with lung cancer (OR = 1.15, P = 7.2 x 10(-8)) and urinary bladder, prostate and cervix cancer (ORs = 1.07-1.31, all P < 4 x 10(-4)).
|
19151717 |
2009 |
|
Liver carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
In conclusion, our findings suggest that rs401681 is a possible prognostic biomarker for HCC patients.
|
29042796 |
2017 |
|
Small cell carcinoma of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
We identified 3 loci, 20q13.2 (rs4809957G >A), 22q12.2 (rs36600C >T) and 5p15.33 (rs401681C >T), significantly associated with the survival time of SCLC patients.
|
25415319 |
2014 |
|
Liver carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Both the rs2736098 T allele of TERT and the rs401681 T allele of CLPTM1L were associated with a significantly increased risk of HCC (adjusted odds ratio [OR]=1.605, 95% confidence interval [CI]=1.164-2.213; adjusted OR=1.399, 95%CI=1.002-1.955, respectively).
|
25339005 |
2014 |
|
Squamous cell carcinoma of esophagus
|
|
0.020 |
GeneticVariation
|
BEFREE |
TERT-CLPTM1L rs401681 CT and CT/TT genotypes were associated with decreased risk of ESCC, particularly among men, young patients and those reported to be drinkers.
|
25007268 |
2014 |
|
Squamous cell carcinoma of esophagus
|
|
0.020 |
GeneticVariation
|
BEFREE |
In addition, we investigated the correlation between the rs401681 variant and the risk of ESCC in a Han Chinese population, and our results suggest that this genetic variant may not be involved in ESCC risk.
|
24386361 |
2013 |
|
Small cell carcinoma of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found that the rs401681C/T allele in the TERT-CLPTM1L gene was associated with the risk of non-small cell lung cancer [NSCLC; P = 0.012, odds ratio (OR) = 1.29, 95% confidence interval (95%CI) = 1.09-1.50], but was not associated with the risk of small cell lung cancer (P = 0.571, OR = 1.15, 95%CI = 0.82-1.47).
|
23359026 |
2013 |
|
Experimental Organism Basal Cell Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
The rs401681 polymorphism was significantly associated with a decreased risk of lung cancer, bladder cancer, and basal cell carcinoma in Asians and in hospital-based studies.
|
29254260 |
2017 |
|
Squamous cell carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
In addition, we find both rs402710 and rs401681 conferred significantly greater risks for adenocarcinoma and squamous cell carcinoma when stratified by histological type of tumors.
|
24907075 |
2014 |
|
Squamous cell carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Stratification analysis by histology type indicated that rs401681 T genotypes were associated with a significantly reduced risk of both adenocarcinoma and squamous cell carcinoma.
|
24386361 |
2013 |
|
Experimental Organism Basal Cell Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
These findings suggested that rs401681 C allele was a low-penetrance risk allele for the development of cancers of lung, bladder, prostate and basal cell carcinoma, but a potential protective allele for melanoma and pancreatic cancer.
|
23226346 |
2012 |
|
Experimental Organism Basal Cell Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
We evaluated the associations between 39 SNPs, including 38 tag-SNPs in telomere-related genes (TERT, TRF1, TRF2, TNKS2, and POT1) and one SNP (rs401681) in the TERT-CLPTM1L locus which has been identified as a susceptibility locus to skin cancer in the previous GWAS, and the risk of skin cancer in a case-control study of Caucasians nested within the Nurses' Health Study (NHS) among 218 melanoma cases, 285 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCC) cases, and 870 controls.
|
21116649 |
2011 |