|
Serum albumin measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genetic determinants influencing human serum metabolome among African Americans.
|
24625756 |
2014 |
|
Serum albumin measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genetic determinants influencing human serum metabolome among African Americans.
|
24625756 |
2014 |
|
Alzheimer's Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
In a case-control study including 376 late-onset AD patients and 444 control subjects, we showed a statistically significant effect on the risk of AD of two variants (rs4343 and rs1799752) and of the haplotype ATI (rs4343/rs4291/rs1799752) in subjects aged 73 years and above.
|
19539712 |
2009 |
|
Alzheimer's Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Other variants, such as SNPs rs4291A>T located -240bp from the initiation codon, and rs4343G>A encoding a silent mutation in exon 16, were inconsistently associated with the risk of AD.
|
19539712 |
2009 |
|
Alzheimer's Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
The purpose of this study was to examine the impact of two polymorphisms (rs4291A>T and rs4343G>A) in the ACE gene on the risk of Alzheimer's disease (AD), using a population-based cohort of 9294 subjects selected from the electoral rolls of three French cities (the Three-City Study).
|
18431000 |
2008 |
|
Alzheimer's Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
These results suggest that a variant in close proximity to rs4343 and rs4351 modulates susceptibility to AD in this community.
|
16642441 |
2006 |
|
Acute Chest Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study aims to investigate the impact of ACE (rs4343) and AT1R (rs 5182) genetic polymorphisms on the outcome of acute coronary syndrome (ACS) in patients on captopril.
|
31195108 |
2020 |
|
Acute Coronary Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study aims to investigate the impact of ACE (rs4343) and AT1R (rs 5182) genetic polymorphisms on the outcome of acute coronary syndrome (ACS) in patients on captopril.
|
31195108 |
2020 |
|
Non-obstructive azoospermia
|
|
0.010 |
GeneticVariation
|
BEFREE |
CONCLUSIONS No significant association was found between ACE SNPs rs4316, rs4331, rs4343, or rs4362 and NOA in the Chinese Han population of Northeast China.
|
31198195 |
2019 |
|
Left Ventricular Hypertrophy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Increased ACE activity explains the significant association of rs4343 and rs4291 polymorphisms with LVH in the carriers.
|
28513230 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
The ACE rs4343 variant is a novel nutrient-sensitive type 2 diabetes risk marker potentially applicable for nutrigenetic dietary counseling.
|
28835639 |
2017 |
|
Heart failure with preserved ejection fraction [HFpEF]
|
|
0.010 |
GeneticVariation
|
BEFREE |
A total of 176 hypertensive patients with a diagnosis of HFpEF were divided to cases with LVH and controls without. rs4343 and rs4291 of angiotensin-converting enzyme (ACE) and rs5186 of angiotensin receptor type 1 were genotyped using PCR-RFLP method.
|
28513230 |
2017 |
|
Congenital Heart Defects
|
|
0.010 |
GeneticVariation
|
BEFREE |
Relationship of the MTHFD1 (rs2236225), eNOS (rs1799983), CBS (rs2850144) and ACE (rs4343) gene polymorphisms in a population of Iranian pediatric patients with congenital heart defects.
|
28865601 |
2017 |
|
Autistic Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Considering the relation between the three polymorphisms of ACE (I/D, rs4343 and rs4291) with the level of ACE activity, we have investigated this association with autism, in a case-control study.
|
27082637 |
2016 |
|
Crohn Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Both rs4343 A/G and rs4646994 I/D allele frequencies differed significantly between patients with CD and control subjects (rs4343: OR=1.438, 95% CI=1.099-1.882, P=0.008; rs4646994: OR=1.559, 95% CI=1.191-2.039, P=0.001).
|
26823847 |
2015 |
|
Alzheimer Disease, Late Onset
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study showed that the polymorphisms of rs5516, rs710446, rs2304456, rs4291 and rs4343 is not related to the incidence of LOAD.
|
26884824 |
2015 |
|
Degenerative polyarthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant correlation exists between ACE rs4343 and rs4362 polymorphisms and OA.
|
26261641 |
2015 |
|
Kidney Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
ACE ID/DD genotypes in combination with ACE rs4311, rs4343, and AGT rs699 mutant genotypes increased the risk of DNP development fourfold (p < 0.01).
|
19108684 |
2009 |