rs4444235, None

N. diseases: 23
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
COLORECTAL CANCER, SUSCEPTIBILITY TO, 12
0.700 GeneticVariation GWASCAT Novel Common Genetic Susceptibility Loci for Colorectal Cancer. 29917119 2019
Colorectal Neoplasms
CUI: C0009404
Disease: Colorectal Neoplasms
0.700 GeneticVariation GWASCAT Novel Common Genetic Susceptibility Loci for Colorectal Cancer. 29917119 2019
COLORECTAL CANCER, SUSCEPTIBILITY TO, 10
0.700 GeneticVariation GWASCAT Genome-wide association study of colorectal cancer identifies six new susceptibility loci. 26151821 2015
COLORECTAL CANCER, SUSCEPTIBILITY TO, 12
0.700 GeneticVariation GWASCAT Genome-wide association study of colorectal cancer identifies six new susceptibility loci. 26151821 2015
Adenocarcinoma of large intestine
CUI: C1319315
Disease: Adenocarcinoma of large intestine
0.700 GeneticVariation GWASCAT Genome-wide association study of colorectal cancer identifies six new susceptibility loci. 26151821 2015
COLORECTAL CANCER, SUSCEPTIBILITY TO, 1
0.700 GeneticVariation GWASCAT Genome-wide association study of colorectal cancer identifies six new susceptibility loci. 26151821 2015
COLORECTAL CANCER, SUSCEPTIBILITY TO, 3
0.700 GeneticVariation GWASCAT Genome-wide association study of colorectal cancer identifies six new susceptibility loci. 26151821 2015
Malignant neoplasm of large intestine
0.700 GeneticVariation GWASCAT Genome-wide association study of colorectal cancer identifies six new susceptibility loci. 26151821 2015
Colorectal Neoplasms
CUI: C0009404
Disease: Colorectal Neoplasms
0.700 GeneticVariation GWASCAT Genome-wide association study of colorectal cancer identifies six new susceptibility loci. 26151821 2015
Nasopharyngeal carcinoma
CUI: C2931822
Disease: Nasopharyngeal carcinoma
0.700 GeneticVariation GWASDB A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. 20512145 2010
COLORECTAL CANCER, SUSCEPTIBILITY TO, 10
0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. 19011631 2008
COLORECTAL CANCER, SUSCEPTIBILITY TO, 12
0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. 19011631 2008
Adenocarcinoma of large intestine
CUI: C1319315
Disease: Adenocarcinoma of large intestine
0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. 19011631 2008
COLORECTAL CANCER, SUSCEPTIBILITY TO, 1
0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. 19011631 2008
Malignant neoplasm of large intestine
0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. 19011631 2008
Colorectal Neoplasms
CUI: C0009404
Disease: Colorectal Neoplasms
0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. 19011631 2008
COLORECTAL CANCER, SUSCEPTIBILITY TO, 3
0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. 19011631 2008
Malignant neoplasm of colon and/or rectum
0.050 GeneticVariation BEFREE The SNP rs4444235 at 14q22.2 interacted with regular exercise in colorectal cancer (p<sub>case-only</sub> = 2.4 × 10<sup>- 3</sup>, p<sub>case-control</sub> = 1.5 × 10<sup>- 3</sup>). 31849324 2019
Malignant neoplasm of colon and/or rectum
0.050 GeneticVariation BEFREE Genome-wide association studies have identified rs4444235 at BMP4 as a new colorectal cancer (CRC) and colorectal adenoma (CRA) susceptibility locus in populations of European descent. 25647270 2015
Malignant neoplasm of colon and/or rectum
0.050 GeneticVariation BEFREE The common variant rs4444235 near BMP4 confers genetic susceptibility of colorectal cancer: an updated meta-analysis based on a comprehensive statistical strategy. 24932582 2014
Malignant neoplasm of colon and/or rectum
0.050 GeneticVariation BEFREE BMP4 rs4444235 is a candidate susceptibility allele that has been associated with an increased risk of colore</span>ctal cancer. 22170598 2012
Malignant neoplasm of colon and/or rectum
0.050 GeneticVariation BEFREE We observed an association between the low colorectal cancer risk allele (A) for rs10795668 at 10p14 and increased expression of ATP5C1 (q = 0.024) and between the colorectal cancer high risk allele (C) for rs4444235 at 14q22.2 and increased expression of DLGAP5 (q = 0.041), both in tumor samples. 22363440 2012
Carcinogenesis
CUI: C0596263
Disease: Carcinogenesis
0.010 GeneticVariation BEFREE Our results suggest that SNP rs4444235 at 14q22.2 and SNP rs2423279 at 20p12.3 may interact with regular exercise and aspirin use in colorectal carcinogenesis. 31849324 2019
Adenoma of large intestine
CUI: C1302401
Disease: Adenoma of large intestine
0.010 GeneticVariation BEFREE Our findings demonstrated that BMP4-rs4444235 is a risk factor associated with increased CRC and CRA susceptibility, but these associations vary in different ethnic populations. 25647270 2015
Malignant neoplasm of esophagus
CUI: C0546837
Disease: Malignant neoplasm of esophagus
0.010 GeneticVariation BEFREE The minor alleles of rs1321311 and rs4444235 were associated with a 1.53-fold (95%CI: 1.15-2.06; P = 0.004) and 1.28-fold (95%CI: 1.03-1.60; P = 0.028) increased risk of esophageal cancer in the allelic model analysis, respectively. 26078566 2015