|
Obesity
|
|
0.710 |
GeneticVariation
|
BEFREE |
Replication of the nominal associations with obesity could not be confirmed in a German genome-wide association (GWA) study for rs4684677 and rs572169 polymorphisms.
|
19165163 |
2009 |
|
Obesity
|
|
0.710 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
|
Mild cognitive disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
No significant differences were found for the distributions of genotype and allele of ghrelin rs4684677 polymorphism between MCI and control group.
|
28146431 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
We aimed to investigate the association of plasma ghrelin levels and ghrelin rs4684677 polymorphism with mild cognitive impairment (MCI) in T2DM patients.
|
28146431 |
2017 |
|
Hashimoto Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
In women group, rs4684677 T alleles were more frequent compared to healthy controls (99%) in HT (p = 0.02) with OR = 6.7 and 95% confidence interval for OR: 1.2-168.37.
|
25868387 |
2015 |
|
Thyroid Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
The association between rs4684677 T/A polymorphism in preproghrelin gene and predisposition to autoimmune thyroid diseases in children.
|
25868387 |
2015 |
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In contrast, the rs4684677 GHRL and the rs572169 GHSR polymorphisms conferred increased breast cancer risk (OR 1.97-1.98, p = 0.08 and OR 1.42-1.43, p = 0.08, respectively).
|
25376984 |
2014 |
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
In contrast, the rs4684677 GHRL and the rs572169 GHSR polymorphisms conferred increased breast cancer risk (OR 1.97-1.98, p = 0.08 and OR 1.42-1.43, p = 0.08, respectively).
|
25376984 |
2014 |
|
Drug usage
|
|
0.010 |
GeneticVariation
|
BEFREE |
A significant association between the GHRL SNP rs4684677 and ASI composite score of drug use was also reported (pc = 0.03).
|
23579732 |
2013 |
|
Panic Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
The A allele of the rs4684677 polymorphism was significantly associated with panic disorder, while there were no significant associations with the two other polymorphisms studied.
|
23084284 |
2013 |
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
One SNP, rs4684677 (Leu90Gln), showed a marginal association with age of AD onset.
|
22005651 |
2011 |
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, the A-501C SNP was found to be associated with early disease onset, and Gln90Leu SNP with less frequent rheumatoid factor positivity, in the RA group.
|
21145775 |
2011 |
|
Anorexia Nervosa
|
|
0.010 |
GeneticVariation
|
BEFREE |
We therefore re-investigated the association between AN and the Leu72Met and Gln90Leu polymorphisms of the prepro-ghrelin/obestatin gene, the Ala67Thr polymorphism of AgRP and the Val66Met polymorphism of BDNF taking into account clinical subtypes (restrictive--ANR--and bingeing/purging--ANB--subtypes).
|
17197106 |
2007 |
|
Metabolic Syndrome X
|
|
0.010 |
GeneticVariation
|
BEFREE |
We genotyped 856 Amish samples for three missense polymorphisms in GHRL, Arg51Gln, Leu72Met (rs696217), and Gln90Leu (rs4684677) and performed association analyses with eating behavior traits and metabolic syndrome as defined by the National Cholesterol Education Program Adult Treatment Panel III guidelines.
|
16204371 |
2005 |