|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
BEFREE |
We found a significant association between CDKAL1 polymorphisms (rs4712523, OR 1.42, p = 9.44 × 10-5; rs4712524, OR 1.38, p = 3.28 × 10-4; rs10946398, OR 1.43, p = 6.21 × 10-5; rs7754840, OR 1.43, p = 6.33 × 10-5; rs35612982, OR 1.34, p = 0.0010; and rs10440833, OR 1.32, p = 0.0018) and T2D risk among the Han population from Northwest China.
|
31639799 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
BEFREE |
All the five SNPs were significantly associated with T2D risk with overall effects (odds ratio, OR) from 1.19 to 1.29 in the additive genetic model (rs6931514: OR=1.29, 95% confidence intervals (95% CI)=1.19-1.39, P=5.6 × 10(-10); rs7756992: OR=1.23, 95% CI=1.15-1.32, P=1.2 × 10(-8); rs4712523: OR=1.25, 95% CI=1.15-1.35, P=3.8 × 10(-8); rs4712524: OR=1.24, 95% CI=1.15-1.35, P=6.8 × 10(-8); rs9472138: OR=1.19, 95% CI=1.05-1.34, P=006).
|
22437209 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
BEFREE |
In accordance with the findings in mice, a nominally significant (P<0.05) association between CDKAL1 rs4712523 and BMI was replicated in 2 Japanese general populations comprising 5,695 and 12,569 samples; the risk allele for type 2 diabetes was also associated with decreased BMI.
|
23173044 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
|
22158537 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
GWASDB |
A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B.
|
20818381 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
GWASCAT |
Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
|
19401414 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
GWASCAT |
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.
|
19734900 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
GWASDB |
Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
|
19401414 |
2009 |
|
Coronary heart disease
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
|
Autoantibody measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.
|
19734900 |
2009 |