|
Meningococcal Infections
|
|
0.030 |
GeneticVariation
|
BEFREE |
The allele frequency of the Asp299Gly polymorphism was 5.9% among 879 blood donors, 6.5% among 1047 patients with microbiologically proven meningococcal disease, and 4.1% among 86 patients who died of meningococcal disease.
|
11494169 |
2001 |
|
Arteriosclerosis
|
|
0.090 |
GeneticVariation
|
BEFREE |
The Asp299Gly TLR4 polymorphism, which attenuates receptor signaling and diminishes the inflammatory response to gram-negative pathogens, is associated with a decreased risk of atherosclerosis.
|
12124407 |
2002 |
|
Atherosclerosis
|
|
0.090 |
GeneticVariation
|
BEFREE |
The Asp299Gly TLR4 polymorphism, which attenuates receptor signaling and diminishes the inflammatory response to gram-negative pathogens, is associated with a decreased risk of atherosclerosis.
|
12124407 |
2002 |
|
Septicemia
|
|
0.090 |
GeneticVariation
|
BEFREE |
Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphism(s) with outcome in an intensive care unit (ICU) population at risk for sepsis.
|
12404174 |
2002 |
|
Sepsis
|
|
0.090 |
GeneticVariation
|
BEFREE |
Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphism(s) with outcome in an intensive care unit (ICU) population at risk for sepsis.
|
12404174 |
2002 |
|
Sepsis
|
|
0.090 |
GeneticVariation
|
BEFREE |
To investigate whether the presence of the TLR4(D299G) mutation may correlate with the development or outcome of sepsis following major visceral surgery the presence of TLR4(D299G) mutation was analysed in 307 Caucasian patients (154 without and 153 with sepsis).
|
12807489 |
2003 |
|
Arteriosclerosis
|
|
0.090 |
GeneticVariation
|
BEFREE |
1400 participants (mean age: 63 years, 31% female) in the Southampton Atherosclerosis Study were genotyped for the TLR4 Asp299Gly polymorphism using the tetra-primer PCR method.
|
12957699 |
2003 |
|
Atherosclerosis
|
|
0.090 |
GeneticVariation
|
BEFREE |
1400 participants (mean age: 63 years, 31% female) in the Southampton Atherosclerosis Study were genotyped for the TLR4 Asp299Gly polymorphism using the tetra-primer PCR method.
|
12957699 |
2003 |
|
Septicemia
|
|
0.090 |
GeneticVariation
|
BEFREE |
To investigate whether the presence of the TLR4(D299G) mutation may correlate with the development or outcome of sepsis following major visceral surgery the presence of TLR4(D299G) mutation was analysed in 307 Caucasian patients (154 without and 153 with sepsis).
|
12807489 |
2003 |
|
Coronary Artery Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
Among symptomatic men with documented coronary artery disease, the TLR4 Asp299Gly polymorphism was associated with the risk of cardiovascular events.
|
12742999 |
2003 |
|
Coronary heart disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
Among symptomatic men with documented coronary artery disease, the TLR4 Asp299Gly polymorphism was associated with the risk of cardiovascular events.
|
12742999 |
2003 |
|
Coronary heart disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
The findings of this study do not support the hypothesis that the TLR4 Asp299Gly polymorphism influences predisposition to and progression of coronary artery disease.
|
12957699 |
2003 |
|
Coronary Artery Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
The findings of this study do not support the hypothesis that the TLR4 Asp299Gly polymorphism influences predisposition to and progression of coronary artery disease.
|
12957699 |
2003 |
|
Coronary Arteriosclerosis
|
|
0.060 |
GeneticVariation
|
BEFREE |
Among symptomatic men with documented coronary artery disease, the TLR4 Asp299Gly polymorphism was associated with the risk of cardiovascular events.
|
12742999 |
2003 |
|
Coronary Arteriosclerosis
|
|
0.060 |
GeneticVariation
|
BEFREE |
The findings of this study do not support the hypothesis that the TLR4 Asp299Gly polymorphism influences predisposition to and progression of coronary artery disease.
|
12957699 |
2003 |
|
Carotid Atherosclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The Asp299Gly polymorphism in the toll-like receptor 4 (TLR4) gene reduces responsiveness to lipopolysaccharide and has been associated with reduced incidence and slower progression of carotid atherosclerosis.
|
12957699 |
2003 |
|
Multiple Sclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
In this study we determined whether genetic variants of toll-like receptor (TLR) 4, which confer substantial differences in the inflammation elicited by bacterial lipopolysaccharide, are related to the development of MS. We found no differences in the frequencies of the cosegregating TLR4 Asp299Gly and Thr399Ile polymorphisms between Austrian MS patients (11.6%) and age-matched controls (13.7%).
|
12622779 |
2003 |
|
Acute Coronary Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results, which must be confirmed by a prospective longitudinal study, provide evidence of an association between the Asp299Gly polymorphism of the human TLR4 receptor and acute coronary syndromes.
|
14563652 |
2003 |
|
Coronary Stenosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
TLR4 Asp299Gly polymorphism is not associated with coronary artery stenosis.
|
12957699 |
2003 |
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
We have reported on a novel association of the TLR4 Asp299Gly polymorphism with both CD and UC.
|
15194649 |
2004 |
|
Ulcerative Colitis
|
|
0.800 |
GeneticVariation
|
BEFREE |
We have reported on a novel association of the TLR4 Asp299Gly polymorphism with both CD and UC.
|
15194649 |
2004 |
|
Inflammatory Bowel Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
A TDT on 318 IBD trios demonstrated preferential transmission of the TLR4 Asp299Gly polymorphism from heterozygous parents to affected children (T/U: 68/34, p = 0.01).
|
15194649 |
2004 |
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated, by using a polymerase chain reaction restriction-fragment length polymorphism method, the possible association between the polymorphisms of TLR2 (Arg677Trp and Arg753Gln) and TLR4 (Asp299Gly and Thr399Ile) genes with the susceptibility or severity of RA and SLE.
|
14651524 |
2004 |
|
Atherosclerosis
|
|
0.090 |
GeneticVariation
|
BEFREE |
The presence of the Asp299Gly allele of the TLR4 gene does not seem to exert a major influence on the progression of atherosclerosis in patients with FH.
|
14764071 |
2004 |
|
Arteriosclerosis
|
|
0.090 |
GeneticVariation
|
BEFREE |
The presence of the Asp299Gly allele of the TLR4 gene does not seem to exert a major influence on the progression of atherosclerosis in patients with FH.
|
14764071 |
2004 |