|
Segmental vitiligo
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of Nod-like receptor protein-1 (rs2670660) and Toll-like receptor-4 (rs4986790) with non-segmental vitiligo: A case-control study in South Indian population.
|
31293094 |
2019 |
|
Infection in children
|
|
0.010 |
GeneticVariation
|
BEFREE |
The objectives of the study were to evaluate the associations between both TLR4 rs4986790 and rs4986791 gene polymorphisms and H. pylori infection in children with gastritis.
|
31690518 |
2019 |
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
A coding variant in the TLR4 receptor (rs4986790), previously associated with longevity and Alzheimer's disease (AD) risk reduction, was examined in a population isolate (Québec Founder Population [QFP]) and in presymptomatic individuals with a parental history of AD (Pre-Symptomatic Evaluation of Novel or Experimental Treatment for Alzheimer's Disease [PREVENT-AD]).
|
31175027 |
2019 |
|
Osteitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The findings suggest that TLR4 has no significant role in the emergence of osteitis after newborn BCG vaccination, but the variant genotypes of the TLR4 rs4986790 and rs4986791 may impair the production of pro-inflammatory cytokines.
|
31755594 |
2019 |
|
Acute pyelonephritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Patients with APN were significantly more likely to have AA genotype of the ICAM-1 rs5498 (1462 A/G) polymorphism (p = 0.04) than children with lower UTIs and the TLR-4 Asp299Gly GG genotype (p = 0.002) and G allele (p = 0.006) than healthy controls.
|
29028278 |
2018 |
|
Cystic echinococcosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The potential role of toll-like receptor 4 Asp299Gly polymorphism and its association with recurrent cystic echinococcosis in postoperative patients.
|
29602972 |
2018 |
|
Cystic Echinocccosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
A relative genetic variability of TLR4 Asp299Gly was found in RH patients (haplotype diversity: 0.700) compared to AH patients and healthy controls (Hd: 0.000).
|
29602972 |
2018 |
|
Echinococcosis, Hepatic
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Asp299Gly genotype was dominantly identified in patients with hepatic hydatid cysts.
|
29602972 |
2018 |
|
Echinococcosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
A relative genetic variability of TLR4 Asp299Gly was found in RH patients (haplotype diversity: 0.700) compared to AH patients and healthy controls (Hd: 0.000).
|
29602972 |
2018 |
|
Complete atrioventricular block
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, no significant association was found for the missense variant TLR4 (rs4986790) NM_138554.4:c.896A>G (p.Asp299Gly) polymorphism and CHB in Turkish population.
|
29276096 |
2018 |
|
Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
A phenotypic correlation of Asp299Gly-AG genotype with arthritis in UC patients was detected (P = 0.003).
|
29055077 |
2017 |
|
Glaucoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Comparing cases to controls as regards co-morbidity with other systemic diseases, there were no statistically significant differences between groups in all assessed diseases except for a family history of glaucoma (p = 0.014) Conclusions: In conclusion, we could not detect any direct link between genotypes or allele frequencies of SNP rs4986790 in the TLR4 gene and POAG.
|
27064537 |
2017 |
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our data indicate that any correlation was not found between rs4986790 polymorphism and lung cancer, while a correlation between rs4986791 and lung cancer has been determined and found to be associated with lung cancer risk.
|
26299699 |
2016 |
|
Cysticercosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We also performed a literature search of cases published in English language using PubMed electronic database and analyzed 56 cases thus available.There was an increased risk (6.63 fold and 4.61 fold) of disseminated cysticercosis in the presence of Asp299Gly and Thr399Ile polymorphisms in Toll-like receptor-4, respectively.
|
27684822 |
2016 |
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our data indicate that any correlation was not found between rs4986790 polymorphism and lung cancer, while a correlation between rs4986791 and lung cancer has been determined and found to be associated with lung cancer risk.
|
26299699 |
2016 |
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our data indicate that any correlation was not found between rs4986790 polymorphism and lung cancer, while a correlation between rs4986791 and lung cancer has been determined and found to be associated with lung cancer risk.
|
26299699 |
2016 |
|
Arthritis, Psoriatic
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant association was observed between a missense variant rs4986790 of TLR4 (Asp229Gly) and plaque type psoriasis (p = 2 × 10(-4)) which was also notable in those with psoriatic arthritis (p = 2 × 10(-4)) and early-onset psoriasis (p = 8 × 10(-4)).
|
26830904 |
2016 |
|
Leukemia, Myelocytic, Acute
|
|
0.010 |
GeneticVariation
|
BEFREE |
We analyzed three SNPs in the TLR2 (Arg753Gln) and TLR4 (Asp299Gly and Thr399Ile) gene in a cohort of 155 patients with AML who received induction chemotherapy.
|
25427560 |
2015 |
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
To evaluate the effect of promoter region polymorphisms of toll-like receptor (TLR)2-196 to -174del and TLR4-1607T/C (rs10759932) on mRNA and protein expression in tumor tissue and of TLR4+896A/G (rs4986790) on colorectal cancer (CRC) risk.
|
26167073 |
2015 |
|
Pneumonia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, the cosegregating TLR4 polymorphisms Asp299Gly and Thr399Ile were independent risk factors for the development of both sepsis and pneumonia (OR: 3.55; 95% CI: 1.21-10.4, P=0.021 and OR: 3.57, 95% CI: 1.3-9.86, P=0.014, respectively).
|
25427560 |
2015 |
|
Acute bronchiolitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found no association between TLR4 polymorphisms (Asp299Gly and Thr399Ile) and the development of acute bronchiolitis.
|
25572736 |
2015 |
|
Chronic purulent otitis media
|
|
0.010 |
GeneticVariation
|
BEFREE |
The objective of this study was to establish expression of TLR 2 and 4 on middle ear mucosa in different types of chronic suppurative otitis media (CSOM), and the influence of gene polymorphisms TLR 2 Arg753Gln and TLR 4 Thr399Ile and Asp299Gly to susceptibility to CSOM.
|
26055429 |
2015 |
|
Chronic kidney disease stage 5
|
|
0.010 |
GeneticVariation
|
BEFREE |
No such association of increased risk of ESRD was observed with TLR4 (Asp299Gly) Asp/Gly genotype and TLR2 polymorphisms.
|
26490558 |
2015 |
|
Kidney Failure, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
No such association of increased risk of ESRD was observed with TLR4 (Asp299Gly) Asp/Gly genotype and TLR2 polymorphisms.
|
26490558 |
2015 |
|
Cerebrovascular Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
In summary, the present meta-analysis indicates that TLR4 gene Asp299Gly polymorphism is not associated with increased ischemic cerebrovascular disease risk.
|
23952655 |
2014 |