|
Asthma
|
|
0.060 |
GeneticVariation
|
BEFREE |
The ADAM33 rs528557/S2 SNP was found to be associated with asthma according to the additive and dominant models.
|
31586488 |
2019 |
|
Asthma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Of the 8 SNPs genotyped, only S2[rs528557] showed significant association with asthma (Allele p = 0.0189, Genotype p = 0.021).
|
26666372 |
2016 |
|
Asthma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Thus, the ADAM33 rs528557 C>G polymorphism may be utilized </span>as a biomarker for early diagnosis of asthma.
|
25068505 |
2014 |
|
Asthma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Smoking may modify the associations between SNPs rs628977 and rs528557 and asthma.
|
22583515 |
2012 |
|
Asthma
|
|
0.060 |
GeneticVariation
|
BEFREE |
In the total cohort, the rs511898 A, rs528557 C, and rs2280090 A alleles increased the risk to develop asthma (+BHR).
|
19236319 |
2009 |
|
Asthma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Two-SNP haplotype analysis at the SNPs rs528557/S2 and rs598418 revealed a significant association with asthma.
|
19317339 |
2008 |
|
Childhood asthma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Positive associations were also found between the polymorphisms rs2280090, rs2787094, rs44707 and rs528557</span> and childhood asthma in some genetic models.
|
28876365 |
2017 |
|
Childhood asthma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The replication of the negative association of the CG/GG-genotype of rs528557 ADAM33 with childhood asthma in an independent birth cohort study confirms that a compromised ADAM33 gene may be implicated in the progression of wheeze into childhood asthma.
|
25768087 |
2015 |
|
Wheezing
|
|
0.010 |
GeneticVariation
|
BEFREE |
The replication of the negative association of the CG/GG-genotype of rs528557 ADAM33 with childhood asthma in an independent birth cohort study confirms that a compromised ADAM33 gene may be implicated in the progression of wheeze into childhood asthma.
|
25768087 |
2015 |
|
Psoriasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed the frequency of the rs2787094 C allele was significantly higher in cases than in controls (50 vs. 33%, P < 0.0001).Similarly, the rs528557 C allele exhibited a significantly increased frequency in PS patients compared with healthy controls (35 vs. 21%, P < 0.0001).
|
24562625 |
2014 |
|
Chronic Obstructive Airway Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results showed that S2 (rs528557) and T1 (rs2280091) polymorphisms did not result in an increased or a decreased risk of COPD.
|
23902466 |
2014 |
|
Bronchial Hyperreactivity
|
|
0.010 |
GeneticVariation
|
BEFREE |
There existed interaction between in utero but not postnatal CSE and the rs528557 and rs3918396 SNPs with respect to development of BHR, the rs3918396 SNP with Rint at age 8 and the rs528557 SNP with FEV(1)% predicted.
|
19236319 |
2009 |