|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.720 |
GeneticVariation
|
BEFREE |
The development of HCC was independently associated with PNPLA3 rs738409 (OR<sub>adjusted</sub> 1.84 [95% CI 1.55-2.18], p = 1.85 × 10<sup>-12</sup>) and TM6SF2 rs58542926 (OR<sub>adjusted</sub> 1.66 [1.30-2.13], p = 5.13 × 10<sup>-05</sup>), using an additive model, and controlling the sex, age, body mass index, and type 2 diabetes mellitus; the risk associated with carriage of MBOAT7 rs641738 (OR<sub>adjusted</sub> 1.04 [0.88-1.24], p = 0.61) was not significant.
|
29535416 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.720 |
GeneticVariation
|
BEFREE |
As variants in PNPLA3 (I148M) and TM6SF2 (E167K) are associated with nonalcoholic fatty liver disease, we assessed these variants in type 2 diabetes (T2D) patients randomized to receive BIL (n=1822) or GL (n=1270) in three phase 3 trials.
|
29160303 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.720 |
GeneticVariation
|
GWASCAT |
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.
|
29632382 |
2018 |
|
Triglycerides measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.
|
30670697 |
2019 |
|
Serum total cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genetic analyses of diverse populations improves discovery for complex traits.
|
31217584 |
2019 |
|
Triglycerides measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genetic analyses of diverse populations improves discovery for complex traits.
|
31217584 |
2019 |
|
Triglycerides measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A large electronic-health-record-based genome-wide study of serum lipids.
|
29507422 |
2018 |
|
Low density lipoprotein cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A large electronic-health-record-based genome-wide study of serum lipids.
|
29507422 |
2018 |
|
Triglycerides measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.
|
29403010 |
2018 |
|
Serum total cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A large electronic-health-record-based genome-wide study of serum lipids.
|
29507422 |
2018 |
|
Serum total cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
The impact of low-frequency and rare variants on lipid levels.
|
25961943 |
2015 |
|
Triglycerides measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
The impact of low-frequency and rare variants on lipid levels.
|
25961943 |
2015 |
|
Vitamin measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based imputation.
|
23696881 |
2013 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The TM6SF2 E167K variant was associated with NAFLD in northeast China, and there was an interaction between the PNPLA3 I148M and TMS6F2 E167K variants in NAFLD.
|
31054977 |
2020 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study aimed to confirm the association of the transmembrane 6 superfamily member 2 (TM6SF2) E167K variant with non-alcoholic fatty liver disease (NAFLD) and the degree of steatosis, as well as the additive effect of body mass index (BMI) or the patatin-like phospholipase domain-containing protein 3 (PNPLA3) I148M and TM6SF2 E167K variants in NAFLD.
|
31054977 |
2020 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs58542926 polymorphism in TM6SF2 (transmembrane 6 superfamily member 2) is a genetic factor predisposing to nonalcoholic fatty liver disease.
|
31356578 |
2020 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
CC genotype of TM6SF2 rs58542926 was associated with a significantly lower risk of NAFLD, while MBOAT7 rs641738 was not related to NAFLD risks.
|
30824369 |
2019 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here, we accessed the seven polymorphisms of rs1260326, rs780094 in GCKR, rs2954021 near TRIB1, rs2228603 in NCAN, rs58542926 in TM6SF2, rs12137855 near LYPLAL1, and rs10883437 near CPN1 on NAFLD susceptibility in the Uygur population.
|
30646922 |
2019 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Metabolic syndrome (MetS) and genetic polymorphisms PNPLA3 rs738409, TM6SF2 rs585</span>42926 and MBOAT7 rs641738 are known inductors of non-alcoholic fatty liver disease (NAFLD).
|
31851849 |
2019 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Importantly, our data indicates that the genetic variant TM6SF2 E167K, previously associated with increased risk for NAFLD, induces increased hepatocyte fat content by reducing APOB particle secretion.
|
31406127 |
2019 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The TM6SF2 rs58542926 T allele promotes the abnormal regulation of lipid profiles and liver injury in NA</span>FLD patients, NAFLD&CRA patients, and overall subjects.
|
30727943 |
2019 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
An I148 M variant in patatin-like phospholipase domain-containing protein 3 (PNPLA3) and an E167K variant in transmembrane 6 superfamily 2 (TM6SF2) are major genetic risk factors for the development and progression of NAFLD.
|
30550414 |
2019 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, it was found that a one-portion increase in fish intake increased the risk of NAFLD in carriers of the risk allele of TM6SF2 rs58542926 polymorphism compared to non-carriers, after adjusting for age, gender, energy intake, pack-years, PAL, TM6SF2 genotype and fish consumption (OR<sub>dominant</sub> = 1.503, 95% CI 1.094-2.064).
|
29574608 |
2019 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Combining the I148M and E167K variants in a manner of an additive effect could improve risk prediction for NAFLD in a Qingdao Han Population cohort.
|
30738435 |
2019 |
|
Steatohepatitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
PRO-C3 concentration appears to be linked to both fibrosis and steatosis and increased in carriers of the TM6SF2 rs58542926 risk allele.
|
30859582 |
2019 |