|
Body Height
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Characterizing rare and low-frequency height-associated variants in the Japanese population.
|
31562340 |
2019 |
|
Severe myopia
|
|
0.040 |
GeneticVariation
|
BEFREE |
This meta-analysis showed there was no association detected between IGF1 rs6214 and high myopia.
|
28135889 |
2017 |
|
Severe myopia
|
|
0.040 |
GeneticVariation
|
BEFREE |
We found a significant association of the IGF-1 gene rs6214 polymorphism in Egyptian patients with simple myopia and high-grade myopia.
|
27167306 |
2016 |
|
Severe myopia
|
|
0.040 |
GeneticVariation
|
BEFREE |
This meta-analysis shows that IGF-1 rs12423791 or rs6214 gene polymorphism is not associated with high myopia.
|
26076017 |
2015 |
|
Severe myopia
|
|
0.040 |
GeneticVariation
|
BEFREE |
To determine the distribution of the HM-associated SNPs rs6214 and rs10860860, 543 unrelated individuals from the general Polish population were also analyzed.
|
21976954 |
2011 |
|
Colorectal Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
In this Dutch case-control study, DNA isolated from blood of 1,457 GI cancer patients; 438 patients with head and neck cancer (HNC), 475 with esophageal cancer (EC) and 544 with colorectal cancer (CRC) and 1,457 matched controls, was used to determine the rs6214 and rs6898743 genotypes by polymerase chain reaction.
|
24608110 |
2014 |
|
Colorectal Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
The associations of four single nucleotide polymorphisms (SNPs) in IGF-I (rs6214), IGFBP-3 (rs3110697), INSR (rs1052371), and IRS2 (rs2289046) genes with the risk of CRC were evaluated using a case-control design with 167 CRC cases and 277 controls by the PCR-RFLP method.
|
24175768 |
2013 |
|
Colorectal Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our results suggest that the SNP rs6214 of IGF1 could have an impact on developing colorectal cancer and colorectal polyps with villous elements.
|
19784788 |
2010 |
|
Myopia
|
|
0.020 |
GeneticVariation
|
BEFREE |
To investigate the effect of the insulin-like growth factor-1 (IGF-1) gene's rs6214 and rs5742632 polymorphisms on IGF-1 expression levels and their association with different types of myopia in Egyptian patients.
|
27167306 |
2016 |
|
Myopia
|
|
0.020 |
GeneticVariation
|
BEFREE |
We investigated whether the IGF-1 single nucleotide polymorphisms (SNPs) rs6214, rs10860860, and rs2946834 are associated with HM (≤-6.0 diopters [D]) and any myopia (≤-0.5 D) phenotype in Polish families.
|
21976954 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
The minor allele of rs6214 was associated with T2D [OR = 1.67 (95% CI 1.39-2.01, p = 4.9E-8)], rs13207351 was associated with NPDR [OR = 1.97 (95% CI 1.28-3.03, p = 9.0E-3)]when compared with DNR, and rs5742632 showed positive association with PDR [OR = 1.66 (95% CI 1.33-2.05, p = 1.0E-4)] compared to DNR.
|
31473834 |
2020 |
|
Obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
Therefore, the aim of the study was to evaluate the association between both, rs6214 polymorphism and milk intake, and obesity.
|
31530040 |
2019 |
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Thus, in stratified analyses, we found that rs6214 was associated with a significantly reduced risk of breast cancer under the allele, heterozygote, and dominant models (A vs G: OR, 0.94, 95% CI,0.88-1.00, P = .044; GA vs GG: OR, 0.88, 95% CI, 0.80-0.97, P = .012; AA + GA vs GG: OR, 0.89, 95% CI, 0.81-0.97, P = .011), as well as pancreatic cancer under the recessive model (AA vs GA + GG: OR, 0.68, 95% CI,0.53-0.87, P = .003).
|
30572549 |
2018 |
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
Thus, in stratified analyses, we found that rs6214 was associated with a significantly reduced risk of breast cancer under the allele, heterozygote, and dominant models (A vs G: OR, 0.94, 95% CI,0.88-1.00, P = .044; GA vs GG: OR, 0.88, 95% CI, 0.80-0.97, P = .012; AA + GA vs GG: OR, 0.89, 95% CI, 0.81-0.97, P = .011), as well as pancreatic cancer under the recessive model (AA vs GA + GG: OR, 0.68, 95% CI,0.53-0.87, P = .003).
|
30572549 |
2018 |
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this meta-analysis, we investigated and reviewed the relationship between IGF1 gene 3'-UTR polymorphisms (rs5742714, rs6214, and rs6220) and cancer risk based on present epidemiological studies.
|
30572549 |
2018 |
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Thus, in stratified analyses, we found that rs6214 was associated with a significantly reduced risk of breast cancer under the allele, heterozygote, and dominant models (A vs G: OR, 0.94, 95% CI,0.88-1.00, P = .044; GA vs GG: OR, 0.88, 95% CI, 0.80-0.97, P = .012; AA + GA vs GG: OR, 0.89, 95% CI, 0.81-0.97, P = .011), as well as pancreatic cancer under the recessive model (AA vs GA + GG: OR, 0.68, 95% CI,0.53-0.87, P = .003).
|
30572549 |
2018 |
|
Malignant neoplasm of pancreas
|
|
0.010 |
GeneticVariation
|
BEFREE |
Thus, in stratified analyses, we found that rs6214 was associated with a significantly reduced risk of breast cancer under the allele, heterozygote, and dominant models (A vs G: OR, 0.94, 95% CI,0.88-1.00, P = .044; GA vs GG: OR, 0.88, 95% CI, 0.80-0.97, P = .012; AA + GA vs GG: OR, 0.89, 95% CI, 0.81-0.97, P = .011), as well as pancreatic cancer under the recessive model (AA vs GA + GG: OR, 0.68, 95% CI,0.53-0.87, P = .003).
|
30572549 |
2018 |
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this meta-analysis, we investigated and reviewed the relationship between IGF1 gene 3'-UTR polymorphisms (rs5742714, rs6214, and rs6220) and cancer risk based on present epidemiological studies.
|
30572549 |
2018 |
|
Simple myopia
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found a significant association of the IGF-1 gene rs6214 polymorphism in Egyptian patients with simple myopia and high-grade myopia.
|
27167306 |
2016 |
|
Hyperlipidemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Elders with GG genotype of rs6214 and AC or CC genotypes of rs2854744 had a 3.18-fold (95% CI 1.02-9.89) risk of having low ASMI compared with those with the AA and AA genotype, after adjusting for age, gender, smoking, exercise, hyperlipidemia, and albumin level.
|
25548030 |
2015 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphisms of rs6214 and rs6218 in the 3'UTR of IGF1 are associated with childhood ALL susceptibility, and the polymorphism of rs6218 is related with IGF1 expression at mRNA level.
|
26159252 |
2015 |
|
Malignant neoplasm of gastrointestinal tract
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, the prevalence of the single nucleotide polymorphisms (SNPs) rs6214 in the IGF type I (IGF-I) gene and rs6898743 in the growth hormone receptor (GHR) gene in patients with GI cancer and controls was studied.
|
24608110 |
2014 |
|
Esophageal carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
An OR of 1.54 (95% CI, 1.05-2.27) was found for EC for genotype AA of rs6214.
|
24608110 |
2014 |
|
Esophageal Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
An OR of 1.54 (95% CI, 1.05-2.27) was found for EC for genotype AA of rs6214.
|
24608110 |
2014 |
|
Malignant neoplasm of esophagus
|
|
0.010 |
GeneticVariation
|
BEFREE |
An OR of 1.54 (95% CI, 1.05-2.27) was found for EC for genotype AA of rs6214.
|
24608110 |
2014 |