|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression.
|
31721892 |
2019 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Insomnia symptom of MDD was not resolved in patients with the A/A genotype of HTR2A-rs6311 when treated with SSRI.
|
31111219 |
2019 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
No significant association was found between the SNPs analysed and response to escitalopram in patients with MDD though a significant association was seen between the side effect of memory loss and rs6311.
|
26261165 |
2015 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was no significant association between FSD and the 5HT2A (rs6311) SNP in patients with MDD on SSRI therapy.
|
24533444 |
2014 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The most replicated findings are the associations between rs6295 (HTR1A gene) G allele or G/G genotype and rs6311 (HTR2A gene) A allele or A/A genotype and MD or depressive symptoms.
|
23547754 |
2013 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The purpose of this study was to determine the prevalence of female SDD, its clinical correlates and association with 5HT2A (rs6311) SNP in patients with major depressive disorder (MDD) treated with SSRIs.
|
23857836 |
2013 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although the current meta-analysis indicated that the SNP rs6311 within the 5-HTR2A gene may be not associated with an increased risk for MDD, the results require further study to acquire more direct evidence.
|
23317793 |
2013 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
To explore the possible relationship between six single nucleotide polymorphisms (SNPs) (rs6311 and rs6305 of 5-HT2A, rs5443 of Gβ3, rs2230739 of ACDY9, rs1549870 of PDE1A and rs255163 of CREB1, which are all related with 5-HT2A the signal transduction pathway) and the response efficacy to selective serotonin reuptake inhibitor (SSRI) treatments in major depressive disorder (MDD) Chinese.
|
22480177 |
2012 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The 5HT2A receptor gene (HTR2A) polymorphisms rs7997012 and rs6311 have in some earlier studies been associated with serotonin selective reuptake inhibitor (SSRI) treatment response in major depressive disorder (MDD), but the findings are inconsistent.
|
21741447 |
2011 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
No relationship found between -1438A/G polymorphism of the serotonin 2A receptor gene (rs6311) and major depression susceptibility in a northeastern Thai population.
|
20589614 |
2010 |
|
Obsessive-Compulsive Disorder
|
|
0.060 |
GeneticVariation
|
BEFREE |
The results showed no association of rs6311 or rs6313 with OCD, but their haplotypes had different distribution patterns in cases and controls.
|
29785111 |
2018 |
|
Obsessive-Compulsive Disorder
|
|
0.060 |
GeneticVariation
|
BEFREE |
Although findings to date are mixed, serotonin transporter polymorphism 5-HTTLPR and HTR2A polymorphism rs6311 (or rs6313) are most consistently associated with OCD.
|
28576508 |
2017 |
|
Obsessive-Compulsive Disorder
|
|
0.060 |
GeneticVariation
|
BEFREE |
Previous research shows that OCD is associated with serotonin-related polymorphisms (5-HTTLPR coded as triallelic and HTR2A rs6311/rs6313) and, in males, a polymorphism involved in catecholamine modulation; COMT (rs4680).
|
26616111 |
2016 |
|
Obsessive-Compulsive Disorder
|
|
0.060 |
GeneticVariation
|
BEFREE |
A previous study showed that a single nucleotide polymorphism (SNP), -1438G/A (rs6311), found in the transcriptional control region of the gene that encodes the serotonin-receptor 2A (HTR2A) was associated with obsessive-compulsive disorder (OCD) in a sample of children and adolescents.
|
21874579 |
2012 |
|
Obsessive-Compulsive Disorder
|
|
0.060 |
GeneticVariation
|
BEFREE |
The purpose of this study is to investigate the association between four serotonergic polymorphisms (STin2 VNTR and 5-HTTLPR of the SLC6A4 gene, and A-1438G (rs6311) and T102C (rs6313) of the HTR2A gene) and OCD.
|
18191318 |
2008 |
|
Obsessive-Compulsive Disorder
|
|
0.060 |
GeneticVariation
|
BEFREE |
Nominally significant association was found at the HTR2A rs6311 polymorphism in subjects with tic disorder and OCD (p = .05), replicating a previous finding in Tourette syndrome and OCD.
|
17241828 |
2007 |
|
Unipolar Depression
|
|
0.050 |
GeneticVariation
|
BEFREE |
We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression.
|
31721892 |
2019 |
|
Unipolar Depression
|
|
0.050 |
GeneticVariation
|
BEFREE |
The study aimed to determine the prevalence of female sexual dysfunction (FSD), its clinical correlates, and association with 5HT2A (rs6311) single nucleotide polymorphisms (SNPs) in patients with major depressive disorder (MDD) who were on SSRI therapy.
|
24533444 |
2014 |
|
Unipolar Depression
|
|
0.050 |
GeneticVariation
|
BEFREE |
Meta-analysis of association between the -1438A/G (rs6311) polymorphism of the serotonin 2A receptor gene and major depressive disorder.
|
23317793 |
2013 |
|
Unipolar Depression
|
|
0.050 |
GeneticVariation
|
BEFREE |
The most replicated findings are the associations between rs6295 (HTR1A gene) G allele or G/G genotype and rs6311 (HTR2A gene) A allele or A/A genotype and MD or depressive symptoms.
|
23547754 |
2013 |
|
Unipolar Depression
|
|
0.050 |
GeneticVariation
|
BEFREE |
No relationship found between -1438A/G polymorphism of the serotonin 2A receptor gene (rs6311) and major depression susceptibility in a northeastern Thai population.
|
20589614 |
2010 |
|
Schizophrenia
|
|
0.030 |
GeneticVariation
|
BEFREE |
A total of 7 gene polymorphisms from DRD2 (rs1800497, rs1079597, rs1800498, rs1801028) and 5-HT2 A (rs6313, rs6311, rs6305) were genotyped for their association with schizophrenia.
|
30389402 |
2019 |
|
Schizophrenia
|
|
0.030 |
GeneticVariation
|
BEFREE |
This meta-analysis indicates that rs6311 and rs6313 polymorphisms of 5-HT<sub>2A</sub>R are not associated with schizophrenia.
|
27598719 |
2017 |
|
Depressive disorder
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our results provide further evidence for the involvement of <i>SLC6A4</i> rs4795541 and <i>HTR2A</i> rs6311 polymorphisms in the pathophysiology of depressive disorders in IBS patients.
|
28951738 |
2017 |
|
Depressive disorder
|
|
0.030 |
GeneticVariation
|
BEFREE |
Based on previous studies indicating that a single nucleotide polymorphism in the serotonin 2A receptor gene [<i>HTR2A</i> rs6311 guanine (G) vs. adenine (A)] is associated with sensitivity to emotional stimuli and several mental disorders such as depression, we predicted that the polymorphism might be associated with the effect of sharing happiness.
|
29311795 |
2017 |