|
Myocardial Infarction
|
|
0.780 |
GeneticVariation
|
BEFREE |
We have previously shown that the C→T polymorphism (rs6929846) of the butyrophilin, subfamily 2, member A1 gene (BTN2A1) was significantly associated with myocardial infarction.
|
24452779 |
2014 |
|
Myocardial Infarction
|
|
0.780 |
GeneticVariation
|
BEFREE |
Multivariable logistic regression analyses with adjustment for covariates revealed that rs6929846 of BTN2A1 was significantly associated with MI in individuals with (P=0.0001; odds ratio, 1.49) or without (P=1.6x10-7; odds ratio, 2.32) hypertension; in individuals with (P=0.0002; odds ratio, 1.65) or without (P=8.1x10-7; odds ratio, 1.76) DM; and in individuals without CKD (P=6.0x10-11; odds ratio, 2.03), but not in those with CKD.
|
21347509 |
2011 |
|
Myocardial Infarction
|
|
0.780 |
GeneticVariation
|
BEFREE |
Given that diabetes mellitus is an important risk factor for myocardial infarction, the association of rs6929846 of BTN2A1 with myocardial infarction might be attributable, at least in part, to its effect on susceptibility to diabetes.
|
21672009 |
2011 |
|
Myocardial Infarction
|
|
0.780 |
GeneticVariation
|
BEFREE |
Given that metabolic syndrome (MetS) is an important risk factor for myocardial infarction, the association of the rs6929846 of BTN2A1 with myocardial infarction</span> might be attributable, at least in part, to its effect on susceptibility to MetS.
|
21784758 |
2011 |
|
Myocardial Infarction
|
|
0.780 |
GeneticVariation
|
BEFREE |
We showed that the C→T polymorphism (rs6929846) of BTN2A1 and A→G polymorphism (rs2569512) of ILF3 were significantly associated with myocardial infarction in Japanese individuals by a genome-wide association study.
|
21557786 |
2011 |
|
Myocardial Infarction
|
|
0.780 |
GeneticVariation
|
BEFREE |
Given that hypertension is a major risk factor for myocar</span>dial infarction, the association of rs6929846 of BTN2A1 with myocardial infarction</span> might be attributable, at least in part, to its effect on susceptibility to hypertension.
|
21525964 |
2011 |
|
Myocardial Infarction
|
|
0.780 |
GeneticVariation
|
BEFREE |
The results suggest that the relationship between rs6929846 of BTN2A1 or rs2569512 of ILF3 and MI is influenced by the serum concentrations of HDL and LDL cholesterol, respectively.
|
21468600 |
2011 |
|
Myocardial Infarction
|
|
0.780 |
GeneticVariation
|
BEFREE |
Seventy single nucleotide polymorphisms (SNPs) significantly (P<1.0×10(-7)) associated with MI by the GWAS were examined further in Japanese subject panel B, revealing two SNPs (rs6929846 of BTN2A1, rs2569512 of ILF3) to be significantly (P<0.0007) associated with MI.
|
21211798 |
2011 |
|
Myocardial Infarction
|
|
0.780 |
GeneticVariation
|
GWASDB |
The rs6929846 SNP of BTN2A1, but not rs2569512 of ILF3, was also significantly associated with MI in Japanese subject panel C. However, the association of neither rs6929846 nor rs2569512 with MI was replicated in the Korean population.
|
21211798 |
2011 |
|
Hypertensive disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Longitudinal analysis with a generalized estimating equation and with adjustment for age, gender, body mass index and smoking status revealed that rs2116519 of family with sequence similarity 78, member B (FAM78B; P=0.0266), rs6929846 of butyrophilin, subfamily 2, member A1 (BTN2A1; P=0.0013), rs146021107 of pancreatic and duodenal homeobox 1 (PDX1; P=0.0031) and rs1671021 of lethal giant larvae homolog 2 (Drosophila) (LLGL2; P=0.0372) were significantly (P<0.05) associated with the prevalence of hypertension.
|
25813534 |
2015 |
|
Chronic Kidney Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
Longitudinal analysis with a generalized estimating equation and with adjustment for covariates revealed that rs6929846 of butyrophilin, subfamily 2, member A1 gene (BTN2A1) was significantly associated with the prevalence of hypertriglyceridemia (P=0.0001), hyper-LDL cholesterolemia (P=0.0004), and CKD (P=0.0007); rs2569512 of interleukin enhancer binding factor 3 (ILF3) was associated with hyper-LDL cholesterolemia (P=0.0029); and rs2074379 (P=0.0019) and rs2074388 (P=0.0029) of alpha-kinase 1 (ALPK1) were associated with CKD.
|
25813695 |
2015 |
|
Diabetes Mellitus
|
|
0.030 |
GeneticVariation
|
BEFREE |
A multivariable logistic regression analysis adjusted for age, gender, body mass index, smoking status and the prevalence of diabetes mellitus revealed that rs6929846 of BTN2A1 was significantly (dominant model; P=2.4x10-4; odds ratio, 1.29) associated with dyslipidemia, with the minor T allele representing a risk for this condition.
|
24452779 |
2014 |
|
Diabetes Mellitus
|
|
0.030 |
GeneticVariation
|
BEFREE |
Multivariable logistic regression analysis of combined genotypes with adjustment for age, gender and diabetes mellitus revealed that rs662799 and rs6929846 significantly and synergistically affected dyslipidemia.
|
22576629 |
2012 |
|
Chronic Kidney Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
Multivariable logistic regression analyses with adjustment for covariates revealed that rs6929846 of BTN2A1 was significantly associated with MI in individuals with (P=0.0001; odds ratio, 1.49) or without (P=1.6x10-7; odds ratio, 2.32) hypertension; in individuals with (P=0.0002; odds ratio, 1.65) or without (P=8.1x10-7; odds ratio, 1.76) DM; and in individuals without CKD (P=6.0x10-11; odds ratio, 2.03), but not in those with CKD.
|
21347509 |
2011 |
|
Diabetes Mellitus
|
|
0.030 |
GeneticVariation
|
BEFREE |
Given that diabetes mellitus is an important risk factor for myocardial infarction, the association of rs6929846 of BTN2A1 with myocardial infarction might be attributable, at least in part, to its effect on susceptibility to diabetes.
|
21672009 |
2011 |
|
Chronic Kidney Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
Multivariable logistic regression analysis with adjustment for covariates revealed that the C→T polymorphism (rs6929846) of BTN2A1 was significantly associated with the prevalence of CKD in subject panels A (P = 0.0422; recessive model; odds ratio, 2.36) and B (P = 0.0386; dominant model; odds ratio, 1.21) with the T allele representing a risk for this condition.
|
21557786 |
2011 |
|
Hypertensive disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Multivariable logistic regression analysis with adjustment for covariates revealed that rs6929846 of BTN2A1 was significantly associated with hypertension in subject panel A (P = 2.6 × 10(-6); odds ratio, 1.69) and in subject panel B (P = 0.0284; odds ratio, 1.24), with the T allele representing a risk factor for hypertension.
|
21525964 |
2011 |
|
Hypertensive disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Multivariable logistic regression analyses with adjustment for covariates revealed that rs6929846 of BTN2A1 was significantly associated with MI in individuals with (P=0.0001; odds ratio, 1.49) or without (P=1.6x10-7; odds ratio, 2.32) hypertension</span>; in individuals with (P=0.0002; odds ratio, 1.65) or without (P=8.1x10-7; odds ratio, 1.76) DM; and in individuals without CKD (P=6.0x10-11; odds ratio, 2.03), but not in those with CKD.
|
21347509 |
2011 |
|
Dyslipidemias
|
|
0.020 |
GeneticVariation
|
BEFREE |
A multivariable logistic regression analysis adjusted for age, gender, body mass index, smoking status and the prevalence of diabetes mellitus revealed that rs6929846 of BTN2A1 was significantly (dominant model; P=2.4x10-4; odds ratio, 1.29) associated with dyslipidemia, with the minor T allele representing a risk for this condition.
|
24452779 |
2014 |
|
Dyslipidemias
|
|
0.020 |
GeneticVariation
|
BEFREE |
Multivariable logistic regression analysis of combined genotypes with adjustment for age, gender and diabetes mellitus revealed that rs662799 and rs6929846 significantly and synergistically affected dyslipidemia.
|
22576629 |
2012 |
|
Metabolic Syndrome X
|
|
0.020 |
GeneticVariation
|
BEFREE |
We previously showed that the -1131T→C polymorphism (rs662799) of the apolipoprotein A-V gene (APOA5) and the C→T polymorphism (rs6929846) of the butyrophilin, subfamily 2, member A1 gene (BTN2A1) were significantly associated with an increased serum concentration of triglycerides, a decreased serum concentration of high density lipoprotein (HDL)-cholesterol, and the prevalence of metabolic syndrome (MetS) in Japanese individuals.
|
22576629 |
2012 |
|
Metabolic Syndrome X
|
|
0.020 |
GeneticVariation
|
BEFREE |
Comparison of genotype distributions using the χ(2) test revealed that the genotype distributions and allele frequencies of rs6929846 were significantly (p<0.05) associated with MetS in Japanese subject panels A (T allele frequency: MetS, 0.091; controls, 0.054; p=6.1×10(-5)) and B (T allele frequency: MetS, 0.091; controls, 0.039; p=0013) but not in the Korean population samples (T allele frequency: MetS, 0.102; controls, 0.125; p=0.0997).
|
21784758 |
2011 |
|
Hyper LDL cholesterolaemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Longitudinal analysis with a generalized estimating equation and with adjustment for covariates revealed that rs6929846 of butyrophilin, subfamily 2, member A1 gene (BTN2A1) was significantly associated with the prevalence of hypertriglyceridemia (P=0.0001), hyper-LDL cholesterolemia (P=0.0004), and CKD (P=0.0007); rs2569512 of interleukin enhancer binding factor 3 (ILF3) was associated with hyper-LDL cholesterolemia (P=0.0029); and rs2074379 (P=0.0019) and rs2074388 (P=0.0029) of alpha-kinase 1 (ALPK1) were associated with CKD.
|
25813695 |
2015 |
|
Hypertriglyceridemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Longitudinal analysis with a generalized estimating equation and with adjustment for covariates revealed that rs6929846 of butyrophilin, subfamily 2, member A1 gene (BTN2A1) was significantly associated with the prevalence of hypertriglyceridemia (P=0.0001), hyper-LDL cholesterolemia (P=0.0004), and CKD (P=0.0007); rs2569512 of interleukin enhancer binding factor 3 (ILF3) was associated with hyper-LDL cholesterolemia (P=0.0029); and rs2074379 (P=0.0019) and rs2074388 (P=0.0029) of alpha-kinase 1 (ALPK1) were associated with CKD.
|
25813695 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
Multivariable logistic regression analysis with adjustment for age, sex, body mass index and smoking status revealed that rs6929846 was significantly associated with Type 2 diabetes (P = 0.0006; odds ratio 1.25) in all individuals, with the T allele representing a risk factor for this condition.
|
21672009 |
2011 |